Home-Based Exercise Tele-Rehabilitation After COVID-19

NCT ID: NCT05425264

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-29

Study Completion Date

2028-01-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The Coronavirus Disease 2019 (COVID-19) pandemic has resulted in catastrophic infections and fatalities across the nation. Many older Veterans with comorbidities are especially vulnerable to complications and poor recovery. This award will investigate the effect of a novel, home-based, supervised, group exercise tele-rehabilitation in Veterans recovered from COVID-19 on cardiopulmonary and physical function.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

There is an urgent need to understand the lasting impact of COVID-19 on the cardiopulmonary system to improve physical function and prevent long-lasting disability. Pertinent knowledge gaps regarding the post-recovery physiology driving any impairments need to be addressed to improve the quality of life in Veterans with prior SARS-CoV-2 infection. Further, it is important to devise successful rehabilitation strategies that can be safely conducted in a Veteran's home. Hence, the investigators propose to utilize VA Video Connect to deliver a home based, supervised group exercise program to Veteran COVID-19 survivors. The objective of this exercise trial is to determine the influence of COVID-19 on cardiorespiratory fitness, pulmonary and physical function and to investigate the effect of a home-based exercise tele-rehabilitation on these outcomes. The study design includes rural and urban sites and investigators with a history of VA rehabilitation collaboration. Moreover, the investigators will explore healthcare disparities related to COVID-19 which are associated with functional decline and may affect sustainability of exercise rehabilitation strategies deployed, if necessary, under social distancing restrictions.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Post SARS-CoV2 (COVID-19)

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Exercise COVID-19 Cardiopulmonary

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Exercise tele-rehabilitation
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Tele-exercise

Exercise training 2x/week at home. Sessions include circuit exercises of aerobic and resistive training stations which are led remotely.

Group Type EXPERIMENTAL

Tele-exercise

Intervention Type OTHER

Exercise training 2x/week at home. Sessions include circuit exercises of aerobic and resistive training stations which are led remotely.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Tele-exercise

Exercise training 2x/week at home. Sessions include circuit exercises of aerobic and resistive training stations which are led remotely.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Veteran
* documented COVID-19 \> 90 days ago
* diagnosis of 2 of following conditions: hypertension, diabetes, cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease OR 1 condition and BMI \> 30 kg/m2

Exclusion Criteria

* myocardial infarction (within 3 months)
* exertional or unstable angina (chest pain that limits activity)
* severe congestive heart failure (EF \< 20% in last year or NYHA Classification III or IV)
* uncontrolled hypertension (SBP \>180 \&/or DBP \> 110 mm Hg at screening)
* screening EKG with ischemia, complex arrhythmia, or high-grade block (per Minnesota Code)
* poorly controlled diabetes mellitus (FBS\>200 mg/dl, RBS \> 299 mg/dl, or HbA1C \> 10)
* treatment for cancer except skin cancer (within 3 months)
* peripheral vascular disease with claudication
* severe arthritis limiting ambulation
* neurologic disease limiting ambulation (weakness requiring assist device; severe neuropathy)
* end stage liver disease (decompensated liver disease)
* End stage renal failure (dialysis)
* severe pulmonary disease (home O2, admission for dyspnea or pneumonia within 1 month)
* high fall risk (history of falls, bone fracture)
* dementia (based on Evaluation to Consent)
* signs or symptoms of any medical comorbidity that would preclude exercise testing or training
* exercises on routine basis (structured aerobic exercise \> 3 time per week)
Minimum Eligible Age

50 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

VA Office of Research and Development

FED

Sponsor Role lead

Baltimore VA Medical Center

FED

Sponsor Role collaborator

Salem Veterans Affairs Medical Center

FED

Sponsor Role collaborator

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Alice S. Ryan, PhD

Role: PRINCIPAL_INVESTIGATOR

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD

Baltimore, Maryland, United States

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Alice S Ryan, PhD

Role: CONTACT

Phone: (410) 605-7851

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Kristina Marcus, MS

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

F3639-R

Identifier Type: -

Identifier Source: org_study_id