Feasibility and Evaluation Study of the UPLUG Hemodialysis Connection Device

NCT ID: NCT05419258

Last Updated: 2024-02-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-06

Study Completion Date

2023-10-30

Brief Summary

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The new Uplug° technology, interface between the end of the hemodialysis catheter and the dialysis circuit, makes it possible to limit direct access to the hemodialysis catheter during connections and disconnections.

Aim:

The investigators propose a feasibility study, in order to study the new Uplug° technology in real conditions of use.

Material and methods:

This study aim to include 15 hemodialysis patients in a center on a tunneled permanent central venous hemodialysis catheter. The Uplug° technology will be placed at the end of each patient's hemodialysis catheter for a period of one month.

Hypothesis tested:

The main endpoint is the proportion of hemodialysis sessions performed successfully with this technology, respecting the usual dialysis prescription.

Detailed Description

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The incidence and prevalence of chronic insufficiency have been growing for several years. Increasingly older patients are treated with chronic hemodialysis. The vascular access of choice remains the arteriovenous fistula and the proportion of hemodialysis patients on the permanent central venous hemodialysis catheter varies from 20 to 35% in dialysis centres. The new Uplug° technology, interface between the end of the hemodialysis catheter and the dialysis circuit, makes it possible to limit direct access to the hemodialysis catheter during connections and disconnections.

Aim:

The investigators propose a feasibility study, in order to study the new Uplug° technology in real conditions of use.

Material and methods:

This study aim to include 15 hemodialysis patients in a center on a tunneled permanent central venous hemodialysis catheter. The inclusion period is three months. The follow-up time for each participant is 6 weeks. Patients with a tunneled permanent central venous hemodialysis catheter and performing dialysis sessions with a flow rate ≥ 300 ml/min may be included. The Uplug° technology will be placed at the end of each patient's hemodialysis catheter for a period of one month.

Hypothesis tested:

The main endpoint is the proportion of hemodialysis sessions performed successfully with this technology, respecting the usual dialysis prescription.

The secondary objectives are the infectious risk, the defects of the experimental device and the hemodialysis catheter or their implementation, the satisfaction of the nursing staff and the patient, the reduction in the number of manipulations and the effective time of these manipulations.

Conditions

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Hemodialysis Renal Insufficiency, Chronic

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

feasibility study on medical device
Primary Study Purpose

DEVICE_FEASIBILITY

Blinding Strategy

NONE

Study Groups

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use of the device during hemodialysis sessions

use of the device during one month during hemodialysis sessions

Group Type EXPERIMENTAL

UPLUG Hemodialysis Connection Device

Intervention Type DEVICE

use of the device UPLUG during 1 month

Interventions

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UPLUG Hemodialysis Connection Device

use of the device UPLUG during 1 month

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* with end-stage chronic renal failure treated by hemodialysis (2 or 3 sessions per week)
* Wearer of a right or left jugular permanent tunneled central venous hemodialysis catheter whose end has been in the superior vena cava or the right atrium for at least 1 month
* Hemodialysis catheter lock used = heparin or 4% citrate
* Expected life expectancy \> 6 months
* Dialysis session preceding inclusion with an average blood flow of at least 300ml/min

Exclusion Criteria

* Patient with a mechanical heart valve
* Patient with an arteriovenous fistula (AVF) that can be used within one month
* Kidney transplant by living donor planned in the following month
* Pregnant or breastfeeding woman
* History of infection on the hemodialysis catheter in place dating from less than 6 months
* Psychiatric or demented patient unable to obtain informed consent
* Patient already included in another protocol
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Caen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Caen Normandie

Caen, , France

Site Status

Countries

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France

Other Identifiers

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21-0265

Identifier Type: -

Identifier Source: org_study_id

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