A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
NCT ID: NCT05418868
Last Updated: 2025-12-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
214 participants
INTERVENTIONAL
2022-06-14
2027-06-08
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
SEQUENTIAL
TREATMENT
NONE
Study Groups
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Part A: Participants receiving CAB 200 mg/mL with rHuPH20
Part A of the study (CAB 200 mg/mL with rHuPh20) has been closed to further enrolment based on preliminary results.
Cabotegravir 200 mg/mL
CAB 200 mg/mL will be administered.
rHuPH20
rHuPH20 will be administered.
Part C: Participants receiving CAB >=400 mg/mL or CAB Formulation I or CAB Formulation J
Cabotegravir >=400 mg/mL
CAB \>=400 mg/mL will be administered by IM or SC injection.
Cabotegravir Formulation I
CAB Formulation I will be administered by IM injection.
CAB Formulation J
CAB Formulation J will be administered by IM injection.
Part E: Participants receiving RPV
RPV
RPV will be administered by IM injection.
Interventions
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Cabotegravir 200 mg/mL
CAB 200 mg/mL will be administered.
Cabotegravir >=400 mg/mL
CAB \>=400 mg/mL will be administered by IM or SC injection.
Cabotegravir Formulation I
CAB Formulation I will be administered by IM injection.
CAB Formulation J
CAB Formulation J will be administered by IM injection.
rHuPH20
rHuPH20 will be administered.
RPV
RPV will be administered by IM injection.
Eligibility Criteria
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Inclusion Criteria
* Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring.
* Body weight \>=40 kilogram (kg) and body mass index (BMI) within the range \>=18 to \<=32 kilogram per meter square (kg/m\^2).
* Participants who are negative on a single test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (approved molecular polymerase chain reaction \[PCR\] laboratory or point of care test), performed on the day of admission. A negative result is required prior to the administration of study intervention on Day 1.
* Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
* Capable of giving written informed consent.
Exclusion Criteria
* Current or chronic history of liver disease or known hepatic or biliary abnormalities.
* History of ongoing or clinically relevant seizure disorder within the previous 2 years, including participants who have required treatment for seizures within this time period.
* Positive SARS-CoV-2 polymerase chain reaction test, having signs and symptoms which in the opinion of the investigator are suggestive of coronavirus disease 2019 (COVID-19) (i.e., fever, cough etc) within 14 days of inpatient admission, or having contact with known COVID-19 positive person/s in the 14 days prior to inpatient admission.
* Human immunodeficiency virus (HIV-1 or HIV-2) infection as indicated by positive antibody/antigen test.
* History of or on-going high-risk behaviors that, in the opinion of the investigator, may put the participant at increased risk for HIV infection including, but not limited to, participants in HIV discordant relationships, or men who report current or prior unprotected anal sex with other men and those reporting prior or current injecting drug use.
* Presence of hepatitis B surface antigen (HBsAg), or positive hepatitis C antibody test result at screening or within 3 months prior to first dose of study treatment.
* Abnormal blood pressure.
* Evidence of previous myocardial infarction.
* Any conduction abnormality (including but not specific to left or right complete bundle branch block, atrioventricular \[AV\] block \[2nd degree or higher\], Wolff- Parkinson-White \[WPW\] syndrome).
* Any significant arrhythmia which, in the opinion of the investigator or the medical monitor, will interfere with the safety for the individual participant.
* One or more exclusionary values for a screening Electrocardiogram (ECG).
* Alanine transaminase (ALT) \>1.5x upper limit of normal (ULN).
* Bilirubin \>1.5xULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35 percent \[%\]).
* Estimated Glomerular Filtration Rate (eGFR) \<60 milliliter per minute (mL/min) using the Chronic Kidney Disease
* Improved Prediction Equations (CKD-EPI) Creatinine Equation (2021).
* Hemoglobin \<12.5 gram per deciliter (g/dL) for men and \<11 g/dL for women.
* Positive pre-study drug/alcohol screen.
* Regular use of tobacco- or nicotine-containing products within 3 months prior to screening; or urinary cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products (e.g., nicotine patches or vaporizing devices).
* Regular alcohol consumption within 6 months prior to the study defined as an average weekly intake of \>14 units for males or \>7 units for females.
* Regular use of known drugs of abuse.
* Concurrent participation in another clinical trial (except imaging trials); or has participated in a clinical trial and received an investigational product within the following time period prior to the first dosing day in this study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
* Participation in the study would result in loss of blood or blood products in excess of 500 mL within 56 days.
* Exposure to more than four (4) new chemical entities within 12 months prior to the first dosing day.
* History of sensitivity to any of the study interventions (or components thereof), a history of drug allergy or other allergy that, in the opinion of the investigator or medical monitor, contraindicates their participation, including a known hypersensitivity to hyaluronidases.
* Current or anticipated need for chronic anti-coagulation therapy.
* Hereditary coagulation and platelet disorders (e.g., hemophilia or Von Willebrand disease \[VWD\]).
* Participant has a tattoo overlying the location of injection or an underlying skin disease or condition (e.g., infection, inflammation, dermatitis, eczema, drug rash, drug allergy, psoriasis, food allergy, urticaria) that, in the opinion of the investigator, may interfere with interpretation of injection site reactions or administration of study intervention.
* Any other clinical condition, behavior or prior therapy that, in the opinion of the investigator, would make the participant unsuitable for the study; unable to comply with dosing requirements; or unable to comply with study visits.
* Participant who in the investigator's judgment poses a significant suicidality risk. Participant's history of suicidal behavior and/or suicidal ideation should be considered when evaluating for suicide risk.
18 Years
55 Years
ALL
Yes
Sponsors
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GlaxoSmithKline
INDUSTRY
Janssen Sciences Ireland Unlimited Company
UNKNOWN
ViiV Healthcare
INDUSTRY
Responsible Party
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Principal Investigators
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GSK Clinical Trials
Role: STUDY_DIRECTOR
ViiV Healthcare
Locations
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GSK Investigational Site
Orlando, Florida, United States
GSK Investigational Site
Las Vegas, Nevada, United States
GSK Investigational Site
Austin, Texas, United States
Countries
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Central Contacts
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EU GSK Clinical Trials Call Center
Role: CONTACT
Phone: +44 (0) 20 89904466
Email: [email protected]
Facility Contacts
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US GSK Clinical Trials Call Center
Role: primary
EU GSK Clinical Trials Call Centre
Role: backup
US GSK Clinical Trials Call Center
Role: primary
EU GSK Clinical Trials Call Centre
Role: backup
Other Identifiers
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218012
Identifier Type: -
Identifier Source: org_study_id