Trial Outcomes & Findings for Le Kip Kip: A Campaign to Change Social Norms and Build Sustainable Demand for PrEP Among Women in South Africa (NCT NCT05417620)

Last Updated: 2025-07-30

Results Overview

De-identified aggregate counts of female sex workers (FSW) and adolescent girls and young women (AGYW) service-users within the TB HIV Care programme database who initiate PrEP during the intervention period. Number of service users in the program database who initiated prep are reported.

Recruitment status

COMPLETED

Study phase

Target enrollment

601 participants

Primary outcome timeframe

12 months

Results posted on

2025-07-30

Participant Flow

A total of 601 participants were enrolled and engaged in HIV prevention services from the TB HIV Care Program. The TB HIV Care program had a total of 25,168 service-users in their database who initiated prep and were included in the analysis.

Unit of analysis: wards

Participant milestones

Participant milestones
Measure	Standard of Care Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Overall Study STARTED	301 50	92 27	55 26	48 26	105 26
Overall Study Service-users in the TB HIV Care Program Database at the Ward-level (Not Enrolled)	17949 50	3091 27	924 26	925 26	2279 26
Overall Study COMPLETED	301 50	92 27	55 26	48 26	105 26
Overall Study NOT COMPLETED	0 0	0 0	0 0	0 0	0 0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Row population differs from the overall as participants had the option to skip or decline to answer certain questions.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Standard of Care n=50 Wards Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign/PrEP Champions/Community Mobilization n=27 Wards PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions n=26 Wards Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization n=26 Wards Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization n=26 Wards Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Total n=155 Wards Total of all reporting groups
Age, Continuous	23.8 years STANDARD_DEVIATION 7.8 • n=301 Participants	26.4 years STANDARD_DEVIATION 7.8 • n=92 Participants	28.2 years STANDARD_DEVIATION 8.8 • n=55 Participants	25.2 years STANDARD_DEVIATION 7.8 • n=48 Participants	24.7 years STANDARD_DEVIATION 7.2 • n=105 Participants	24.9 years STANDARD_DEVIATION 7.9 • n=601 Participants
Age, Customized Age · 15-17	80 Participants n=301 Participants	9 Participants n=92 Participants	2 Participants n=55 Participants	7 Participants n=48 Participants	12 Participants n=105 Participants	110 Participants n=601 Participants
Age, Customized Age · 18-24	117 Participants n=301 Participants	37 Participants n=92 Participants	21 Participants n=55 Participants	18 Participants n=48 Participants	51 Participants n=105 Participants	244 Participants n=601 Participants
Age, Customized Age · 25-29	33 Participants n=301 Participants	17 Participants n=92 Participants	7 Participants n=55 Participants	14 Participants n=48 Participants	20 Participants n=105 Participants	91 Participants n=601 Participants
Age, Customized Age · 30-34	32 Participants n=301 Participants	13 Participants n=92 Participants	11 Participants n=55 Participants	4 Participants n=48 Participants	12 Participants n=105 Participants	72 Participants n=601 Participants
Age, Customized Age · 35+	39 Participants n=301 Participants	16 Participants n=92 Participants	14 Participants n=55 Participants	5 Participants n=48 Participants	10 Participants n=105 Participants	84 Participants n=601 Participants
Sex: Female, Male Female	301 Participants n=301 Participants	92 Participants n=92 Participants	55 Participants n=55 Participants	48 Participants n=48 Participants	105 Participants n=105 Participants	601 Participants n=601 Participants
Sex: Female, Male Male	0 Participants n=301 Participants	0 Participants n=92 Participants	0 Participants n=55 Participants	0 Participants n=48 Participants	0 Participants n=105 Participants	0 Participants n=601 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=301 Participants	0 Participants n=92 Participants	0 Participants n=55 Participants	0 Participants n=48 Participants	0 Participants n=105 Participants	0 Participants n=601 Participants
Race (NIH/OMB) Asian	1 Participants n=301 Participants	0 Participants n=92 Participants	1 Participants n=55 Participants	0 Participants n=48 Participants	1 Participants n=105 Participants	3 Participants n=601 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=301 Participants	0 Participants n=92 Participants	0 Participants n=55 Participants	0 Participants n=48 Participants	0 Participants n=105 Participants	0 Participants n=601 Participants
Race (NIH/OMB) Black or African American	297 Participants n=301 Participants	92 Participants n=92 Participants	54 Participants n=55 Participants	47 Participants n=48 Participants	104 Participants n=105 Participants	594 Participants n=601 Participants
Race (NIH/OMB) White	3 Participants n=301 Participants	0 Participants n=92 Participants	0 Participants n=55 Participants	0 Participants n=48 Participants	0 Participants n=105 Participants	3 Participants n=601 Participants
Race (NIH/OMB) More than one race	0 Participants n=301 Participants	0 Participants n=92 Participants	0 Participants n=55 Participants	1 Participants n=48 Participants	0 Participants n=105 Participants	1 Participants n=601 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=301 Participants	0 Participants n=92 Participants	0 Participants n=55 Participants	0 Participants n=48 Participants	0 Participants n=105 Participants	0 Participants n=601 Participants
Region of Enrollment South Africa	301 Participants n=301 Participants	92 Participants n=92 Participants	55 Participants n=55 Participants	48 Participants n=48 Participants	105 Participants n=105 Participants	601 Participants n=601 Participants
Education Level Currently in school	142 Participants n=293 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	26 Participants n=82 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	15 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	11 Participants n=47 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	57 Participants n=102 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	251 Participants n=569 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Education Level Did not complete highschool	36 Participants n=293 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	16 Participants n=82 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	9 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	10 Participants n=47 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	17 Participants n=102 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	88 Participants n=569 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Education Level Completed highschool	93 Participants n=293 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	31 Participants n=82 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	17 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	21 Participants n=47 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	24 Participants n=102 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	186 Participants n=569 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Education Level Completed university/trade school or higher	22 Participants n=293 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	9 Participants n=82 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	4 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	5 Participants n=47 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	4 Participants n=102 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	44 Participants n=569 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Relationship Status Single	126 Participants n=300 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	32 Participants n=92 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	23 Participants n=54 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	13 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	32 Participants n=105 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	226 Participants n=596 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Relationship Status Steady partner not living together	169 Participants n=300 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	39 Participants n=92 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	14 Participants n=54 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	20 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	58 Participants n=105 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	300 Participants n=596 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Relationship Status Steady partner living together	5 Participants n=300 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	21 Participants n=92 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	17 Participants n=54 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	12 Participants n=45 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	15 Participants n=105 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	70 Participants n=596 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Current Housing Status Owns/rents	66 Participants n=297 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	30 Participants n=91 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	23 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	14 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	32 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	165 Participants n=595 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Current Housing Status Staying with others (e.g., family, friends)	200 Participants n=297 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	56 Participants n=91 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	29 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	34 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	59 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	378 Participants n=595 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Current Housing Status Shelter	9 Participants n=297 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=91 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	1 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	10 Participants n=595 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Current Housing Status Student housing	5 Participants n=297 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	5 Participants n=91 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	3 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	12 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	25 Participants n=595 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Current Housing Status Brothel	17 Participants n=297 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=91 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	0 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	17 Participants n=595 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Currently Taking PrEP	133 Participants n=301 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	58 Participants n=92 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	43 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	27 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	59 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	320 Participants n=600 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.
Smartphone Ownership	224 Participants n=301 Participants	66 Participants n=92 Participants	40 Participants n=55 Participants	29 Participants n=48 Participants	74 Participants n=105 Participants	433 Participants n=601 Participants
Participants With Internet Access	218 Participants n=300 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	69 Participants n=89 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	36 Participants n=55 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	30 Participants n=48 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	78 Participants n=104 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.	431 Participants n=596 Participants • Row population differs from the overall as participants had the option to skip or decline to answer certain questions.

PRIMARY outcome

Timeframe: 12 months

Population: The analysis population are de-identified aggregate FSW and AGYW service-users in the TB HIV Care program database that initiated PrEP during the study period.

Outcome measures

Outcome measures
Measure	Standard of Care n=17949 Participants Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign n=3091 Participants Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions n=924 Participants Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization n=925 Participants Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization n=2279 Participants Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Number of Service-users Who Initiate PrEP Uptake Within the TB HIV Care Programme	17949 Participants	3091 Participants	924 Participants	925 Participants	2279 Participants

SECONDARY outcome

Timeframe: Month 1

Population: The analysis population are de-identified aggregate FSW and AGYW service-users in the TB HIV Care programme database who initiated PrEP during the trial period and due for a 1-month follow-up visit. The intervention arms are grouped under the social influence campaign intervention as per the study protocol's analytic approach.

Proportion of FSW/AGYW clients within the TB HIV Care programme database who return for 1-month follow-up visit. For each district, the proportion of clients who returned for this visit was calculated. The mean proportion across the standard of care and intervention districts is reported.

Outcome measures

Outcome measures
Measure	Standard of Care n=5 Districts Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign n=5 Districts Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Proportion of PrEP Persistence at 1-month Within the TB HIV Care Programme	42.88 percentage of participants Interval 8.88 to 76.88	27.60 percentage of participants Interval -9.92 to 65.12	—	—	—

SECONDARY outcome

Timeframe: Month 4

Population: The analysis population are de-identified aggregate FSW and AGYW service users in the TB HIV Care programme database who initiated PrEP during the trial period and due for a 4-month follow-up visit. The intervention arms are grouped under the social influence campaign intervention as per the study protocol's analytic approach.

Proportion of FSW/AGYW clients within the TB HIV Care programme database who return for 4-month follow-up visit. For each district, the proportion of clients who returned for this visit was calculated. The mean proportion across the standard of care and intervention districts is reported.

Outcome measures

Outcome measures
Measure	Standard of Care n=5 Districts Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign n=5 Districts Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Proportion of PrEP Persistence at 4 Months Within the TB HIV Care Programme	29.48 percentage of participants Interval 7.14 to 57.85	15.56 percentage of participants Interval -3.5 to 34.47	—	—	—

SECONDARY outcome

Timeframe: Month 12

Population: As outlined in the protocol, acceptability of the social media campaign was assessed among post-intervention cross-sectional survey respondents who reported exposure to the Le Kip Kip social influence campaign.

Acceptability: Respondents who reported intervention acceptability captured in post-trial cross-sectional survey

Outcome measures

Outcome measures
Measure	Standard of Care n=153 Participants Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Number of Participants Who Found Intervention Acceptable	137 Participants	—	—	—	—

SECONDARY outcome

Timeframe: Month 12

Population: The analysis population is the number Facebook users that have seen the content.

Service user uptake and engagement with campaign measured via the number of Facebook page visits. Facebook users who visited the campaign content is reported.

Outcome measures

Outcome measures
Measure	Standard of Care n=631493 Participants Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Adoption as Assessed by Number of Facebook Page Visits by Unique Users	52608 visits	—	—	—	—

SECONDARY outcome

Timeframe: Month 12

Population: This analysis does not involve any participants

Total cost associated with planning, designing, and implementing the social influence campaign will be assessed via review of detailed study budgets. The reported value represents a single point estimate (in USD) of the total cost incurred, based on actual budget expenditures. Because this is a cumulative total cost, non-sampled financial figure, measures of dispersion/precision are not applicable. This outcome measure is based on a review of detailed study budgets related to the planning, design, and implementation of the social influence campaign.The unit analyzed is the campaign itself and analyzed as the overall cost of the Enhanced social media campaign/PrEP champions/Community mobilization arm per protocol.

Outcome measures

Outcome measures
Measure	Standard of Care Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign n=1 Social Influence Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Total Cost	—	223736 Dollars	—	—	—

SECONDARY outcome

Timeframe: Month 12

Population: As outlined in the protocol, penetration of the social influence campaign is captured by post-intervention cross-sectional survey respondents from selected standard of care and intervention districts who answered questions regarding the reach of the Le Kip Kip campaign to their families, peers, and partners.

Extent to which the social influence campaign reached FSW/AGYW and their families/peers/partners measured via descriptive statistics from post-trial survey questions on campaign exposure and perceptions of the campaign among FSW/AGYW and their social support networks.

Outcome measures

Outcome measures
Measure	Standard of Care n=600 Participants Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Penetration as Assessed by Number of Participants Who Report Engagement With Campaign Among Social Support Networks Peers	106 Participants	—	—	—	—
Penetration as Assessed by Number of Participants Who Report Engagement With Campaign Among Social Support Networks Families	68 Participants	—	—	—	—
Penetration as Assessed by Number of Participants Who Report Engagement With Campaign Among Social Support Networks Partners	41 Participants	—	—	—	—

SECONDARY outcome

Timeframe: Month 12

Population: As outlined in the protocol, participants were not included in assessing fidelity of on-schedule posts, rather posts made across social media platforms were analyzed.

Extent to which the social influence campaign was carried out according to plan measured via social media metrics to determine whether static and video content were shared across platforms as planned. Fidelity is assessed by tracking adherence to the planned posting schedule. Participants were not included in assessing fidelity of on-schedule posts, rather posts made across social media platforms were analyzed. Adherence was assessed by documenting whether all scheduled posts were successfully and timely published as planned during the campaign period.

Outcome measures

Outcome measures
Measure	Standard of Care n=300 Posts Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Fidelity as Assessed by Percentage of On-Schedule Posts Content Posting Frequency	300 Posts	—	—	—	—
Fidelity as Assessed by Percentage of On-Schedule Posts Boosted Post Frequency	100 Posts	—	—	—	—

SECONDARY outcome

Timeframe: 12 months

Population: As outlined in the protocol, adoption will be assessed using social media metrics and analytics from the number of unique users who have seen the Le Kip Kip Facebook page content at least once.

Service user uptake and engagement with campaign as assessed by number of times each ad was viewed overall and number of video views.

Outcome measures

Outcome measures
Measure	Standard of Care n=300 Posts Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Adoption as Assessed by Number of Views by Unique Users Number of times each ad was viewed	576384 views	—	—	—	—
Adoption as Assessed by Number of Views by Unique Users Number of times a video was viewed	44081 views	—	—	—	—

SECONDARY outcome

Timeframe: 12 months

Service user uptake and engagement with campaign measured via the number of times someone clicked on each ad

Outcome measures

Outcome measures
Measure	Standard of Care n=300 Posts Full-time peer educators employed by the TB HIV Care programme to engage women, layer PrEP promotion across prevention programs, and implement "refer a friend" strategies, information, education and communication (IEC) materials, service user testimonials, risk reduction posters to increase young women's perception of risk, working after hours/weekends to reach young women, working with school governing bodies, and door-to-door outreach.	Enhanced Social Media Campaign Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts.	Enhanced Social Media Campaign + PrEP Champions Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve.	Enhanced Social Media Campaign + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.	Enhanced Social Media Campaign + PrEP Champions + Community Mobilization Social Media Campaign: PrEP social influence campaign, which will use online approaches to promote PrEP within communities in addition to the standard of care activities. A combination of static imagery and brief videos will be used to engage these groups via social media platforms. A Facebook page will be created and maintained that can be accessed by anyone anywhere, but will only be advertised/promoted in the intervention districts. PrEP Champions: Venue-based PrEP champions will receive supplies (e.g. a hat, pin and posters, flyers, IEC material) to wear to promote PrEP, facilitate linkage between women interested in PrEP and the TB HIV Care PrEP programme. PrEP champions will be either peers with experience taking PrEP, venue managers or local influencers that have repeated contact with the women the programme is intended to serve. Community Mobilization: PrEP community mobilization teams will be recruited to promote PrEP. The team will present information about PrEP and the PrEP programme at the ward councilors meeting, Learning Support Agent meetings with parents/guardians, local events/fairs, community meetings and through engaging men, women and parents across the community through informal conversations. Teams will be wearing branded material and will focus on presenting factual information and decreasing PrEP stigma.
Adoption as Assessed by Number of Ad Clicks	35934 clicks	—	—	—	—

SECONDARY outcome

Timeframe: 12 months

Population: As outlined in the protocol, the extent to which the social influence campaign was carried out according to plan as assessed via programme logs completed by PrEP champions and community mobilizers.

Extent to which the social influence campaign was carried out according to plan was measured via trainings, logs of communication with PrEP champions, and community mobilization logs/quality assessments.