Mitochondrial Oxygraphy on Subcutaneous and Peri-visceral Adipose Tissue: Influence of Body Composition

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

67 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-04-14

Study Completion Date

2023-04-12

Brief Summary

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The objective of this study is to adapt the oxygraphy technique on human adipocytes and to characterize respiration measurements according to patients' body mass index and white adipose tissue localization (subcutaneous vs visceral).

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Detailed Description

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During digestive surgery: oncological and bariatric surgery, it is possible to collect a small volume of subcutaneous and epiplonic adipose tissue (10-20 cc). We wish to collect these samples in order to develop the technique of oxygenography on permeabilized adipocytes. In order to characterize these measurements, they will be related to the clinical data of the patients usually collected in the framework of the preoperative assessment including the body mass index (BMI). The measured adipocyte data will thus be normalized to three BMI classes: ≤ 20, \> to 20 \< 30, and ≥ to 30 kg∙m-2.

Primary end point is to validate the measurement of mitochondrial respiration under oxidophosphorylating conditions by determining indicators of the distribution of mitochondrial respiration values (mean, standard deviation, skewness, kurtosis, coefficient of variation) as a function of patients' body mass index.

Conditions

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Digestive Organs--Cancer Bariatric Surgery Candidate Parietal Region Trauma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

all participants receive the same intervention

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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All patients

a sample of adipose tissue will be collected during the scheduled surgery

Group Type EXPERIMENTAL

adipose surgery

Intervention Type PROCEDURE

A quantity of adipose tissue equivalent to 10-20 cubic centimeter will be removed subcutaneously and from the omentum during surgical procedures (oncological, bariatric)

Interventions

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adipose surgery

A quantity of adipose tissue equivalent to 10-20 cubic centimeter will be removed subcutaneously and from the omentum during surgical procedures (oncological, bariatric)

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing oncological, bariatric, parietal surgery
* Patients able to give an informed consent
* Patients affiliated to an Health Care insurance
* Patients aged over 18

Exclusion Criteria

* Patients under guardianship, curatorship or deprived of freedom
* Pregnant or breastfeeding women
* Participation refusal
* Patients under chemotherapy
* Patients with peritonitis and infectious parietal processes

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No