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Taurine Supplementation Associated or Not With Exercise: Effect on Browning of White Adipose Tissue in Elderly Women With Sarcopenic Obesity

NCT ID: NCT05415176

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-02-27

Study Completion Date

2024-06-01

Brief Summary

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The aging process is followed by metabolic and body composition changes, increasing the risk of obesity and sarcopenia. The coexistence of these conditions acts synergistically on each other and is known as sarcopenic obesity. Beige adipose tissue is a tissue type that emerges from subcutaneous white adipose tissue (WAT), altering its phenotype to resemble the thermogenic functions of brown adipose tissue (BAT) in response to beta-adrenergic stimuli. Some in vitro and animal studies suggest that taurine supplementation and physical exercise are effective interventions in stimulating the aforementioned tissue, promoting what is known as WAT darkening, improving energy metabolism and showing benefits on the maintenance of muscle mass via stimulation of the coactivating protein PGC1α. These investigations are scarce in humans and could help health professionals in the adjuvant treatment of sarcopenic obesity. Therefore, the aim of the present study is to analyze the effects of taurine supplementation associated or not with physical exercise on the darkening of the WAT in sarcopenic obese elderly women.

Detailed Description

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The aging process is followed by metabolic and body composition changes, increasing the risk of obesity and sarcopenia. The coexistence of these conditions acts synergistically on each other and is known as sarcopenic obesity. Beige adipose tissue is a tissue type that emerges from subcutaneous white adipose tissue (WAT), altering its phenotype to resemble the thermogenic functions of brown adipose tissue (BAT) in response to beta-adrenergic stimuli. Some in vitro and animal studies suggest that taurine supplementation and physical exercise are effective interventions in stimulating the aforementioned tissue, promoting what is known as WAT darkening, improving energy metabolism and showing benefits on the maintenance of muscle mass via stimulation of the coactivating protein PGC1α. These investigations are scarce in humans and could help health professionals in the adjuvant treatment of sarcopenic obesity. Therefore, the aim of the present study is to analyze the effects of taurine supplementation associated or not with physical exercise on the darkening of the WAT in sarcopenic obese elderly women. Volunteers with low appendicular lean mass (\<15 kg) and body mass index (BMI) between 30 and 40 kg/m² will be recruited. These will be subdivided into 4 groups: control group (Cont), taurine (Tau), exercise (Exe) and exercise and taurine (Exe +Tau) and the duration of the intervention for all groups will be 16 weeks. Data related to anthropometry, body composition, biochemical tests, and food intake will be collected. To evaluate the effects on the darkening, a biopsy of the abdominal subcutaneous white adipose tissue will be performed to analyze protein, lipidomic and genetic parameters of this tissue pre and post intervention. Data will be analyzed by Analysis of Variance (ANOVA) or Kruskal-Wallis test depending on the normality of the data that will be tested by Shapiro-Wilk. A significance level for p \<0.05 will be admitted. All analyzes will be performed in SPSS version 20 software.

Conditions

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Browning of Subcutaneous White Adipose Tissue Post Intervention Metabolic and Inflammatory Variables Post Intervention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized clinical trial.
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Taurine and Exercise (Tau+Exe)

Individuals who will receive 3g of taurine supplementation combined with physical training in the period of 16 weeks

Group Type EXPERIMENTAL

Taurine supplementation

Intervention Type DIETARY_SUPPLEMENT

Participants will receive 3g of taurine to be supplemented in the morning in single-dose capsules. The intervention will last 16 weeks.

Pshysical exercise

Intervention Type OTHER

Participants will perform a multicomponent type workout that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 16 weeks

Taurine (Tau)

Individuals who will receive 3g of taurine supplementation

Group Type EXPERIMENTAL

Taurine supplementation

Intervention Type DIETARY_SUPPLEMENT

Participants will receive 3g of taurine to be supplemented in the morning in single-dose capsules. The intervention will last 16 weeks.

Exercise (Exe)

Individuals who will perform a physical training and receive a placebo supplementation in the period of 16 weeks

Group Type EXPERIMENTAL

Pshysical exercise

Intervention Type OTHER

Participants will perform a multicomponent type workout that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 16 weeks

Placebo (Cont)

Individuals who will receive a placebo supplementation in the period of 16 weeks

Group Type PLACEBO_COMPARATOR

Placebo control

Intervention Type OTHER

The participants will receive a supplementation capsule containing placebo in the morning in single-dose capsules. The intervention will last 16 weeks.

Interventions

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Taurine supplementation

Participants will receive 3g of taurine to be supplemented in the morning in single-dose capsules. The intervention will last 16 weeks.

Intervention Type DIETARY_SUPPLEMENT

Pshysical exercise

Participants will perform a multicomponent type workout that explores strength, aerobic and balance capacities with load progression every 15 days. The sessions will last 60 minutes each, being held three times a week with a day of rest in between. The intervention will last 16 weeks

Intervention Type OTHER

Placebo control

The participants will receive a supplementation capsule containing placebo in the morning in single-dose capsules. The intervention will last 16 weeks.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI between 30 and 40kg/m²;
* Appendicular lean mass below 15 kg;
* Dynamometry below the cutoff point adjusted for sex and BMI (less than or equal to 21kg);
* "Sit and stand" test below the cut-off point adjusted for the age group, considering the number of repetitions in 30 seconds;
* Present medical certificate to perform physical exercise

Exclusion Criteria

* alcoholics
* smokers
* diseases that prevents the practice of physical activity
* medical impediment to the practice of physical exercise throughout the study
* infectious diseases
* coronary diseases
* chronic kidney diseases
* undergoing nutritional monitoring or weight loss treatment
* score ≤13 for cognitive screening on the Mini-Mental State Examination (MMSE)
Minimum Eligible Age

60 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Ellen Cristini de Freitas

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ellen C de Freitas, PhD

Role: PRINCIPAL_INVESTIGATOR

University of São Paulo, School of Physical Education and Sports of Ribeirão Preto Ph.D. +55 16 3602-0345 [email protected]

Locations

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Escola de Educação Física e Esporte de Ribeirão Preto

Ribeirão Preto, São Paulo, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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Taurine_exercise_browning

Identifier Type: -

Identifier Source: org_study_id