Radiofrequency Hyperthermia Safety Study

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-27

Study Completion Date

2023-10-23

Brief Summary

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This study will include 20 healthy subjects with intact skin on their lower legs that meet inclusion criteria. Participants will serve as their own control, by heating one leg and not the other. The radiofrequency device consists of a 4 by 6 inch heating pad connected to a temperature controller. Subjects will receive weekly treatments for 4 weeks, and will be re-evaluated 4 weeks after the last treatment to assess any tissue changes that continue after the treatments have concluded.

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Detailed Description

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This study will include 20 healthy subjects with intact skin on their lower legs that meet inclusion criteria below. Participants will serve as their own control, by heating one leg and not the other. The radiofrequency device consists of a 4 by 6 inch heating pad connected to a temperature controller. The pad will be applied to the back of the leg and will covered using a compression stocking. The other leg will receive a pad and compression stocking, but radiofrequency will not be applied (no heating).

At the first visit, subjects will be asked to fill out a healthcare questionnaire. With each weekly treatment, subjects will be evaluated to assess how their legs feel on a scale of 1-10, with 1 being no discomfort and 10 being intense pain. Their legs will be photographed before and after radiofrequency MH to examine any visible changes to the tissue. Study team will then use a PeriScan PIM 3 System Laser Doppler scanning for blood perfusion before the Thermofield treatment. The radiofrequency will be set to achieve 40°C/107.6°F) and maintain this temperature consistently during the application time. This temperature is mild and may feel like a drugstore heating pad. The device will be turned on on one leg and will remain off on the other. The time for the heating will be 36 minutes, during which participants will remain in a reclined position, with their legs elevated. The device takes approximately 6 minutes to achieve a tissue temperature of 40°C, and the treatment time with consistent temperature application will be 30 minutes. Study team will then use a PeriScan PIM 3 System Laser Doppler scanning for blood perfusion after the Thermofield treatment ends. Study team will take thermal imaging photographs of the treatment area following each treatment.

Subjects will receive weekly treatments for 4 weeks, and will be re-evaluated 4 weeks after the last treatment to assess any tissue changes that continue after the treatments have concluded. Subjects will be excluded from the study if they develop any kind of intolerance to the MH treatment, like increased pain or unexpected skin changes. If they receive a significant injury or wound that is not due to the study, such that the skin of the lower leg is no longer intact, they will be excluded from the study.

Conditions

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Chronic Pain Soft Tissue Injuries Wound Heal Blood Flow

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

20 healthy subjects with intact skin on their lower legs that meet inclusion criteria - Participants will serve as their own control, by heating one leg and no the other.

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Thermofield temperature controlled radiofrequency device

Participants will serve as their own control, by heating one leg and not the other. The radiofrequency device consists of a 4 by 6 inch heating pad connected to a temperature controller. The pad will be applied to the back of the leg and will covered using a compression stocking. The other leg will receive a pad and compression stocking, but radiofrequency will not be applied (no heating).

Group Type EXPERIMENTAL

Laser Doppler

Intervention Type DEVICE

Study team will use a PeriScan PIM 3 System Laser Doppler to scan for blood perfusion before and after the Thermofield treatment. The PeriScan PIM 3 System is for non-invasive two-dimensional imaging of peripheral tissue.

Radiofrequency Heating System

Intervention Type DEVICE

The radiofrequency will be set to achieve 42°C/107.6°F) and maintain this temperature consistently during the application time. This temperature is mild and may feel like a drugstore heating pad. The device will be turned on on one leg and will remain off on the other. The time for the heating will be 36 minutes, during which participants will remain in a reclined position, with their legs elevated. The device takes approximately 6 minutes to achieve a tissue temperature of 42°C, and the treatment time with consistent temperature application will be 30 minutes.

Thermal Imaging

Intervention Type DEVICE

Study team will take thermal imaging photographs of the treatment area following each treatment.

Healthcare Questionnaire & Measurement

Intervention Type OTHER

A survey tool created to collect info from participants including:

1. Name
2. Age
3. Weight/ height
4. Pregnant or nursing?
5. History of blood clots?
6. Any wound healing problems?
7. Any active open wounds on the legs?
8. Any autoimmune disorders?
9. Phone number
10. Email address

A measurement of the participants calf will be taken as well using a measuring tape.

Interventions

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Laser Doppler

Study team will use a PeriScan PIM 3 System Laser Doppler to scan for blood perfusion before and after the Thermofield treatment. The PeriScan PIM 3 System is for non-invasive two-dimensional imaging of peripheral tissue.

Intervention Type DEVICE

Radiofrequency Heating System

The radiofrequency will be set to achieve 42°C/107.6°F) and maintain this temperature consistently during the application time. This temperature is mild and may feel like a drugstore heating pad. The device will be turned on on one leg and will remain off on the other. The time for the heating will be 36 minutes, during which participants will remain in a reclined position, with their legs elevated. The device takes approximately 6 minutes to achieve a tissue temperature of 42°C, and the treatment time with consistent temperature application will be 30 minutes.

Intervention Type DEVICE

Thermal Imaging

Study team will take thermal imaging photographs of the treatment area following each treatment.

Intervention Type DEVICE

Healthcare Questionnaire & Measurement

A survey tool created to collect info from participants including:

1. Name
2. Age
3. Weight/ height
4. Pregnant or nursing?
5. History of blood clots?
6. Any wound healing problems?
7. Any active open wounds on the legs?
8. Any autoimmune disorders?
9. Phone number
10. Email address

A measurement of the participants calf will be taken as well using a measuring tape.

Intervention Type OTHER

Other Intervention Names

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PeriScan PIM 3 System Laser Doppler Thermofield

Eligibility Criteria

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Inclusion Criteria

* 18 years or older
* Healthy
* 20\<BMI\<40

Exclusion Criteria

* Pregnant, nursing or child bearing potential
* Active infections of the skin in the lower leg
* Open or healing wounds on the lower leg
* Autoimmune disorder
* 40\<BMI \<20
* History of blood clots
* History of lower limb edema
* Tattoos and metal hardware in the leg

Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes