Platelet Transfusion Refractoriness

NCT ID: NCT05399693

Last Updated: 2026-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-02

Study Completion Date

2023-08-08

Brief Summary

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Platelet Transfusion Refractoriness is one of the severe complications after multiple transfusions in patients with severe thrombopenia. Platelet Transfusion Refractoriness is characterized by inefficient transfusion and arise from allo-antibodies specific of platelets antigenes, mostly carried by HLA-I molecules.

Detailed Description

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A preliminary study has shown different isotypes of anti-HLA I in patients with Platelet Transfusion Refractoriness. Our hypothesis is that the type of anti-HLA I antibodies (recognised epitope, quantity, isotype) should establish predictive and diagnostic criteria for Platelet Transfusion Refractoriness.

Conditions

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Platelet Transfusion Refractoriness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with Platelet Transfusion Refractoriness

platelet transfusion

Intervention Type PROCEDURE

platelet transfusion realised for Hematopoietic stem cells graft or for acute leukemia

Patients without Platelet Transfusion Refractoriness

platelet transfusion

Intervention Type PROCEDURE

platelet transfusion realised for Hematopoietic stem cells graft or for acute leukemia

Interventions

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platelet transfusion

platelet transfusion realised for Hematopoietic stem cells graft or for acute leukemia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adult patient with Hematopoietic stem cells graft (autograft or allograft) or with acute leukemia with the indication of platelet transfusion.

Exclusion Criteria

* Patient under guardianship
* Minor patient
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut de cancérologie Strasbourg Europe

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Luc FORNECKER

Role: PRINCIPAL_INVESTIGATOR

Institut de cancérologie Strasbourg Europe

Locations

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Institut de cancérologie Strasbourg Europe

Strasbourg, , France

Site Status

Countries

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France

Other Identifiers

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2021-006

Identifier Type: -

Identifier Source: org_study_id

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