Substance Use Prevention for Youth With Parents in Recovery

NCT ID: NCT05397691

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-29

Study Completion Date

2026-03-31

Brief Summary

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Risk for substance use disorder (SUD) begins early in the life course. Although preventing and decreasing illicit and nonmedical drug use among youth is an urgent public health priority, there are currently few evidence-based prevention strategies feasible for delivery in the primary care setting. The investigators propose a three-year plan to collect critical pilot data to pilot test and optimize a dyadic intervention that aims to increase family resilience, strengthen coping skills, help families plan for the future, and prevent youth SUD.

The 'prototype' for the intervention approach is Family Talk, an evidence-based parent-youth dyadic intervention that can be delivered within the existing infrastructure of the patient-centered medical home. The investigators have made preliminary adaptations to the model in preparation for testing. To prepare for a subsequent efficacy study, a two-arm pilot randomized controlled trial of the intervention with 40 parent-youth dyads to optimize the intervention model will be conducted. The feasibility of the intervention will be evaluated. In addition, empiric estimates of study parameters to inform the planning of a fully powered randomized controlled trial and plausible intervention targets using semi-structured qualitative interviews will be obtained.

Detailed Description

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Within the context of a pilot randomized controlled trial, the objectives are to: 1. Optimize the content and delivery of the intervention through an iterative series of quality improvement cycles informed by structured feedback from parents, youth, and intervention providers after each session; 2. Field test study logistics, including participant recruitment, willingness to consent to a randomized trial; loss to follow-up; the acceptability and feasibility of the study measures; and 3. Obtain empiric estimates of study parameters to inform future clinical trial design, including within-group standard deviation of continuous measures; correlations of repeated measures; and proportion of control group subjects who experience each outcome. The products at the end of the pilot study will be an optimized intervention model, developed with parent and youth input and ready for efficacy testing; and a set of putative intervention targets ready to be tested in the subsequent trial. The ultimate goal is to develop an effective approach to youth substance use prevention, delivered within the infrastructure of the patient-centered medical home. If successful, this trajectory of work has the potential to identify a novel, family-centered approach to substance use disorder prevention for a high-risk population of youth whose parents are in recovery.

Conditions

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Substance Use Disorders

Keywords

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Family Talk Parent-youth dyad Family functioning Coping strategies

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Intervention refinement arm

20 parent-youth \[12-18 years old\] dyads will be randomized to this arm and receive the Modified Family Talk intervention.

Group Type EXPERIMENTAL

Modified Family Talk

Intervention Type OTHER

The Modified Family Talk intervention consists of six modules, each lasting approximately 60 minutes. Family Talk is intended to be delivered over a period of 12 weeks, with meetings occurring every 1-2 weeks.

Parameter estimation arm

20 parent-youth dyads randomized to this control-like arm will receive current best practice care in the patient-centered medical home

Group Type EXPERIMENTAL

Control-like parameter estimation

Intervention Type OTHER

Parameter estimation is designed to emulate best practices around comprehensive, high quality, patient-centered care for adults and youth. Participants will have access to collaborative adult Office Based Addiction Treatment (OBAT) clinical services, multidisciplinary adolescent primary care clinics with co-located adolescent substance use specialists, high quality social work services, integrated behavioral health, and access to patient navigators for assistance connecting to community resources.

Interventions

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Modified Family Talk

The Modified Family Talk intervention consists of six modules, each lasting approximately 60 minutes. Family Talk is intended to be delivered over a period of 12 weeks, with meetings occurring every 1-2 weeks.

Intervention Type OTHER

Control-like parameter estimation

Parameter estimation is designed to emulate best practices around comprehensive, high quality, patient-centered care for adults and youth. Participants will have access to collaborative adult Office Based Addiction Treatment (OBAT) clinical services, multidisciplinary adolescent primary care clinics with co-located adolescent substance use specialists, high quality social work services, integrated behavioral health, and access to patient navigators for assistance connecting to community resources.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 12-18 years without diagnosed SUD
* Comfortable speaking English or Spanish


* 18 years or older
* Receiving treatment for SUD
* Receiving substance use care in the CODAC system
* Comfortable speaking English or Spanish

Exclusion Criteria

* Presence of acute family crisis, such as recent death, incarceration, separation, divorce, or other stressor
* Parent or youth with cognitive limitation or intellectual disability
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Drug Abuse (NIDA)

NIH

Sponsor Role collaborator

National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

Brown University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Caroline J Kistin, MD MSc

Role: PRINCIPAL_INVESTIGATOR

Brown University School of Public Health

Locations

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CODAC

Pawtucket, Rhode Island, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Caroline J Kistin, MD MSc

Role: CONTACT

Phone: 4018632236

Email: [email protected]

Jocelyn Antonio, MPH

Role: CONTACT

Phone: 4018632259

Email: [email protected]

Facility Contacts

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Lily Pike, MD

Role: primary

Other Identifiers

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1R34DA052836-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2022003505

Identifier Type: -

Identifier Source: org_study_id