Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome

NCT ID: NCT05397626

Last Updated: 2022-05-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-23

Study Completion Date

2023-05-23

Brief Summary

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The aim of this 10-week pilot study is to explore the potential benefit of two recently developed non-invasive interventions, heart rate variability biofeedback (HRV-BF) and OTC supplement hydrogen water, for the symptoms of chronic fatigue syndrome (CFS). Symptom measures and heart monitoring information will be generated by this study. Given the lack of effective treatments in this illness, these two non-invasive home-based treatments may help patients feel and function better.

Detailed Description

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The aim of this 10-week pilot study is to explore the potential benefit of two recently developed non-invasive interventions, heart rate variability biofeedback (HRV-BF) and over the counter (OTC) supplement hydrogen water, for the symptoms of chronic fatigue syndrome (CFS). Symptom measures and heart monitoring information will be generated by this study. Given the lack of effective treatments in this illness, these two non-invasive home-based treatments may help patients feel and function better.

Participants will be randomized to one of the three study condition, HRV-BF alone, hydrogen water alone or combined HRV-BF and hydrogen water. All interventions are home-based with no in person visits. All communications with participants will be via virtual call, phone call, email and land mail.

Conditions

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Chronic Fatigue Syndrome

Keywords

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Heart Rhythm Biofeedback; Hydrogen Water

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This clinical study involves three active intervention groups: group 1 receiving heart rhythm biofeedback alone, group receiving hydrogen water alone, and group 3 receiving both heart rhythm biofeedback and hydrogen water.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
Each participant fill out online outcome forms that involve no interaction with the principal investigator or study staff, thus avoiding any staff-specific influence on online outcome forms.

Study Groups

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Heart Rhythm Biofeedback

Heart rhythm biofeedback is a non-invasive physiological treatment that is administered via an app downloaded to personal smart phones. It involves participants attaching a wireless sensor to the ear that monitors heart rate that is displayed on the phone screen app. The participant is actively involved in modifying the heart biofeedback to achieve optimal levels of heart rate variability, an established indicator of health and well-being and a potential factor in chronic fatigue syndrome. The treatment lasts 8 weeks.

Group Type ACTIVE_COMPARATOR

Hydrogen Water

Intervention Type DIETARY_SUPPLEMENT

Hydrogen water, if ingested daily over several weeks, may have antioxidant and anti-inflammatory effects in chronic fatigue syndrome

Combined treatment: Heart rhythm biofeedback plus hydrogen water

Intervention Type COMBINATION_PRODUCT

This treatment is intended to explore the possible additive or synergistic effects of combining heart rhythm biofeedback and hydrogen water.

Hydrogen Water

Hydrogen pills are mixed in a water glass that is ingested up to 3 times a day for 8 weeks. The hydrogen supplement is intended to reduce oxidative stress and inflammation both of which are implicated in the pathophysiology of chronic fatigue syndrome. This is an 8 week treatment.

Group Type ACTIVE_COMPARATOR

Heart Rhythm Biofeedback

Intervention Type BEHAVIORAL

Heart rhythm biofeedback is a non-invasive intervention intended to improve heart rate variability and physical resilience that is often limited in chronic fatigue syndrome

Combined treatment: Heart rhythm biofeedback plus hydrogen water

Intervention Type COMBINATION_PRODUCT

This treatment is intended to explore the possible additive or synergistic effects of combining heart rhythm biofeedback and hydrogen water.

Combined treatment: Heart rhythm biofeedback plus hydrogen water

This condition combines heart rhythm biofeedback and hydrogen water, as described above, which is intended to assess any additive or synergistic effects of the two treatments. This is an 8 week treatment.

Group Type ACTIVE_COMPARATOR

Heart Rhythm Biofeedback

Intervention Type BEHAVIORAL

Heart rhythm biofeedback is a non-invasive intervention intended to improve heart rate variability and physical resilience that is often limited in chronic fatigue syndrome

Hydrogen Water

Intervention Type DIETARY_SUPPLEMENT

Hydrogen water, if ingested daily over several weeks, may have antioxidant and anti-inflammatory effects in chronic fatigue syndrome

Interventions

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Heart Rhythm Biofeedback

Heart rhythm biofeedback is a non-invasive intervention intended to improve heart rate variability and physical resilience that is often limited in chronic fatigue syndrome

Intervention Type BEHAVIORAL

Hydrogen Water

Hydrogen water, if ingested daily over several weeks, may have antioxidant and anti-inflammatory effects in chronic fatigue syndrome

Intervention Type DIETARY_SUPPLEMENT

Combined treatment: Heart rhythm biofeedback plus hydrogen water

This treatment is intended to explore the possible additive or synergistic effects of combining heart rhythm biofeedback and hydrogen water.

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

Diagnosis of chronic fatigue, chronic fatigue syndrome, or something similar. ages 18-65. - BMI\>30.

Exclusion Criteria

* Other major medical condition or regular medication that produces fatigue. No home computer or internet access. No smart phone.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Natural Wellness Now Health Products

UNKNOWN

Sponsor Role collaborator

Stony Brook University

OTHER

Sponsor Role lead

Responsible Party

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Fred Friedberg

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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FRED FRIEDBERG, Phd

Role: PRINCIPAL_INVESTIGATOR

Stony Brook University

Locations

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Fred Friedberg

Stony Brook, New York, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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FRED FRIEDBERG, PhD

Role: CONTACT

Phone: 6316381931

Email: [email protected]

Daniel Gordon, BA

Role: CONTACT

Phone: 6316380056

Facility Contacts

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FRED FRIEDBERG, PhD

Role: primary

Other Identifiers

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AWD00002822

Identifier Type: -

Identifier Source: org_study_id