Trial Outcomes & Findings for Behavioural Science Messages in Breast Cancer Screening (NCT NCT05395871)
NCT ID: NCT05395871
Last Updated: 2025-01-30
Results Overview
Percentage uptake of breast cancer screening, three months after the initial invitation letter- intention to treat.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
34047 participants
Primary outcome timeframe
3 months
Results posted on
2025-01-30
Participant Flow
Participant milestones
| Measure |
Usual Care
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
|---|---|---|---|
|
Overall Study
STARTED
|
11748
|
11047
|
11252
|
|
Overall Study
COMPLETED
|
11748
|
11047
|
11252
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
Baseline characteristics by cohort
| Measure |
Usual Care
n=11748 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
n=11047 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
n=11252 Participants
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
Total
n=34047 Participants
Total of all reporting groups
|
|---|---|---|---|---|
|
Age, Customized
Timed
|
59 years
n=3094 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
59 years
n=2952 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
59 years
n=2981 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
59 years
n=9027 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
|
Age, Customized
Open
|
58 years
n=8654 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
58 years
n=8095 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
57 years
n=8271 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
58 years
n=25020 Participants • Note of the overall population equals to 34047 participants. Total = Timed (9027) + Open (25020) = 34047 Usual care = 3094 + 8654 = 11748 Behavioural message = 2952 + 8095 = 11047 Behavioural mesage + Video = 2981 + 8271 = 11252 9027 received timed invitaitons (3094 usual care, 2952 Behavioural Message and 2981 Behavioural Message + Video). 25020 received open invitations (8654 usual care, 8095 Behavioural Message and 8271 Behavioural Message + Video)
|
|
Sex: Female, Male
Female
|
11748 Participants
n=11748 Participants
|
11047 Participants
n=11047 Participants
|
11252 Participants
n=11252 Participants
|
34047 Participants
n=34047 Participants
|
|
Sex: Female, Male
Male
|
0 Participants
n=11748 Participants
|
0 Participants
n=11047 Participants
|
0 Participants
n=11252 Participants
|
0 Participants
n=34047 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · White
|
4000 Participants
n=11748 Participants
|
3804 Participants
n=11047 Participants
|
3818 Participants
n=11252 Participants
|
11622 Participants
n=34047 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Black
|
810 Participants
n=11748 Participants
|
758 Participants
n=11047 Participants
|
786 Participants
n=11252 Participants
|
2354 Participants
n=34047 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Asian
|
1401 Participants
n=11748 Participants
|
1328 Participants
n=11047 Participants
|
1359 Participants
n=11252 Participants
|
4088 Participants
n=34047 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Mixed
|
133 Participants
n=11748 Participants
|
126 Participants
n=11047 Participants
|
132 Participants
n=11252 Participants
|
391 Participants
n=34047 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Other
|
360 Participants
n=11748 Participants
|
312 Participants
n=11047 Participants
|
335 Participants
n=11252 Participants
|
1007 Participants
n=34047 Participants
|
|
Race/Ethnicity, Customized
Ethnicity · Not stated
|
5044 Participants
n=11748 Participants
|
4719 Participants
n=11047 Participants
|
4822 Participants
n=11252 Participants
|
14585 Participants
n=34047 Participants
|
|
Region of Enrollment
United Kingdom
|
11748 participants
n=11748 Participants
|
11047 participants
n=11047 Participants
|
11252 participants
n=11252 Participants
|
34047 participants
n=34047 Participants
|
|
IMD Decile
IMD 1
|
160 Participants
n=11748 Participants
|
175 Participants
n=11047 Participants
|
214 Participants
n=11252 Participants
|
549 Participants
n=34047 Participants
|
|
IMD Decile
IMD 2
|
1108 Participants
n=11748 Participants
|
992 Participants
n=11047 Participants
|
1008 Participants
n=11252 Participants
|
3108 Participants
n=34047 Participants
|
|
IMD Decile
IMD 3
|
1335 Participants
n=11748 Participants
|
1164 Participants
n=11047 Participants
|
1344 Participants
n=11252 Participants
|
3843 Participants
n=34047 Participants
|
|
IMD Decile
IMD 4
|
1512 Participants
n=11748 Participants
|
1455 Participants
n=11047 Participants
|
1438 Participants
n=11252 Participants
|
4405 Participants
n=34047 Participants
|
|
IMD Decile
IMD 5
|
1465 Participants
n=11748 Participants
|
1436 Participants
n=11047 Participants
|
1383 Participants
n=11252 Participants
|
4284 Participants
n=34047 Participants
|
|
IMD Decile
IMD 6
|
1555 Participants
n=11748 Participants
|
1519 Participants
n=11047 Participants
|
1511 Participants
n=11252 Participants
|
4585 Participants
n=34047 Participants
|
|
IMD Decile
IMD 7
|
1446 Participants
n=11748 Participants
|
1312 Participants
n=11047 Participants
|
1302 Participants
n=11252 Participants
|
4060 Participants
n=34047 Participants
|
|
IMD Decile
IMD 8
|
1383 Participants
n=11748 Participants
|
1291 Participants
n=11047 Participants
|
1318 Participants
n=11252 Participants
|
3992 Participants
n=34047 Participants
|
|
IMD Decile
IMD 9
|
1136 Participants
n=11748 Participants
|
1118 Participants
n=11047 Participants
|
1151 Participants
n=11252 Participants
|
3405 Participants
n=34047 Participants
|
|
IMD Decile
IMD 10
|
625 Participants
n=11748 Participants
|
557 Participants
n=11047 Participants
|
550 Participants
n=11252 Participants
|
1732 Participants
n=34047 Participants
|
|
IMD Decile
Not stated
|
23 Participants
n=11748 Participants
|
28 Participants
n=11047 Participants
|
33 Participants
n=11252 Participants
|
84 Participants
n=34047 Participants
|
|
Invitation Type (open/timed)
Timed
|
3094 Participants
n=11748 Participants
|
2952 Participants
n=11047 Participants
|
2981 Participants
n=11252 Participants
|
9027 Participants
n=34047 Participants
|
|
Invitation Type (open/timed)
Open
|
8654 Participants
n=11748 Participants
|
8095 Participants
n=11047 Participants
|
8271 Participants
n=11252 Participants
|
25020 Participants
n=34047 Participants
|
PRIMARY outcome
Timeframe: 3 monthsPopulation: Timed invitation
Percentage uptake of breast cancer screening, three months after the initial invitation letter- intention to treat.
Outcome measures
| Measure |
Usual Care
n=3094 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
n=2952 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
n=2981 Participants
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
|---|---|---|---|
|
No. of Participants Taking up Breast Cancer Screening at Three Months- Intention to Treat
|
2225 participants
|
2064 participants
|
2137 participants
|
PRIMARY outcome
Timeframe: 3 monthsPopulation: Timed Appointments
No. of participants taking up breast cancer screening, three months after the initial invitation letter- per protocol
Outcome measures
| Measure |
Usual Care
n=2721 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
n=2535 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
n=2615 Participants
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
|---|---|---|---|
|
No. of Participants Taking up Breast Cancer Screening at Three Months- Per Protocol
|
2073 participants
|
1899 participants
|
1977 participants
|
SECONDARY outcome
Timeframe: 3 monthsPopulation: Timed appointments
No. of participants taking up breast cancer screening, three months after the initial invitation letter amongst those from sociodemographic groups (ethnicity) Note there remain 3 trial arms (usual care, behavioural message, behavioural message + video), data represents subgroup analysis dichotomising these arms into white v. non white ethnicity).
Outcome measures
| Measure |
Usual Care
n=3094 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
n=2952 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
n=2981 Participants
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
|---|---|---|---|
|
No. of Participants Taking up Breast Cancer Screening, Three Months After the Initial Invitation Amongst Those From Sociodemographic Groups (Deprivation, Ethnicity)
White
|
1379 participants
|
1276 participants
|
1303 participants
|
|
No. of Participants Taking up Breast Cancer Screening, Three Months After the Initial Invitation Amongst Those From Sociodemographic Groups (Deprivation, Ethnicity)
Non- White
|
1206 participants
|
1194 participants
|
1243 participants
|
SECONDARY outcome
Timeframe: 3 monthsPopulation: Open Invitations
No. of participants taking up breast cancer screening, three months after the initial invitation letter, amongst those given different invitation types.
Outcome measures
| Measure |
Usual Care
n=8654 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
n=8095 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
n=8271 Participants
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
|---|---|---|---|
|
No. of Participants Taking up Uptake of Breast Cancer Screening, Three Months After the Initial Invitation Letter, Amongst Those Given Different Invitation Types.
|
4104 participants
|
3909 participants
|
3978 participants
|
SECONDARY outcome
Timeframe: 3 monthsPopulation: Timed Appointment
No. of participants taking up breast cancer screening, three months after the initial invitation letter, amongst those with different screening history
Outcome measures
| Measure |
Usual Care
n=3094 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the 'usual care' content that is currently sent by the London Breast Cancer Screening Programme. This includes a link to a YouTube hosted video.
Usual Care Message: Standard usual care message involving link to non-behavioural science informed video
|
Behavioural Message
n=2952 Participants
A text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message has been informed by previous co-design work, and incorporate behavioural change techniques. This will include the same link to a YouTube hosted video, as the usual care arm.
Behavioural Message: Messaging involving increased salience, increasing positive emotions and information on health consequences
|
Behavioural Message + Video
n=2981 Participants
An text message sent 7 days prior then 48 hours before a booked/timed appointment. The content of the message will be the same as the Behavioural text, however the link will be replaced with a weblink to an animated video. This video has been designed through an extensive co-design process involving several behavioural change techniques designed to overcome barriers highlighted in this qualitative work.
Behavioural Message + Video: Messaging as above. The video also includes information on emotional consequences, problem solving, anticipated regret, reducing negative emotions and credible source techniques.
|
|---|---|---|---|
|
No. of Participants Taking up Breast Cancer Screening, Three Months After the Initial Invitation Letter, Amongst Those With Different Screening History
First Time Invitee
|
406 participants
|
379 participants
|
394 participants
|
|
No. of Participants Taking up Breast Cancer Screening, Three Months After the Initial Invitation Letter, Amongst Those With Different Screening History
Not First Time Invitee
|
1820 participants
|
1686 participants
|
1743 participants
|
Adverse Events
Usual Care
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Behavioural Message
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Behavioural Message + Video
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place