PD1 and PARP for Maintenance Therapy in NSLLC

NCT ID: NCT05392686

Last Updated: 2022-05-26

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Total Enrollment: 52 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-06-20
• Study Completion Date: 2025-04-01

Brief Summary

PARP inhibitor and PD1 in lung squamous cell carcinoma The current study will compare PD1 plus maintenance PARP for the treatment of squamous NSCLC. The study's 2 primary hypotheses are: respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR).

Overall survival (OS).

Detailed Description

This study has 2 phases: an Induction Phase (4 Cycles) and a Maintenance Phase (Up to 31 cycles ). In the Induction Phase, participants receive pd1 plus carboplatin plus a taxane (paclitaxel or nab-paclitaxel). In the Maintenance Phase, participants with a partial or complete disease response or with stable disease after completing four cycles of induction therapy and who meet eligibility criteria will be randomly assigned to receive PD1 plus maintenance PAPR. In the Maintenance Phase, participants randomly assigned to receive pembrolizumab for up to 31 cycles plus maintenance until centrally verified progressive disease (PD), intolerable toxicities, or physician decision."

Conditions

Lung Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Experimental: PD1 + PARP

For the Induction Phase, participants receive 4 cycles:

PD1 200 mg, intravenous (IV) on Day 1 of each 21-day cycle PLUS carboplatin PLUS a taxane (either paclitaxel or nab-paclitaxel) for 4 cycles (21-day cycles). If the participant has a complete or partial response or stable disease to induction therapy, the participant to maintenance therapy.

For the Maintenance Phase, participants receive PD1 IV on Day 1 of each 21-day for up to 31 cycles PLUS maintenance oral PARP 100 mg twice daily. Until centrally verified progressive disease, physician decision or intolerable toxicity.

Group Type: EXPERIMENTAL

PD-1 inhibitor

Intervention Type: DRUG

Tirelizumab

PARP inhibitor

Intervention Type: DRUG

Fluzopari capsule

Interventions

PD-1 inhibitor

Tirelizumab

Intervention Type: DRUG

PARP inhibitor

Fluzopari capsule

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• 1 NSCLC confirmed by pathology (histology or cytology)

2. First line treatment of patients with immune combined with chemotherapy into immune maintenance treatment;

3. 18-75 years old, both male and female;

2. There are stage IIIA, IIIB or IIIc NSCLC diagnosed according to the 8th edition of the American Joint Committee on cancer.

3. Stage III NSCLC that cannot undergo radical surgery was confirmed and recorded by the multidisciplinary tumor committee or the treating physician in consultation with the thoracic surgeon.

4. In the whole body fluorodeoxyglucose (FDG) - pet or FDG-PET / CT and diagnostic quality CT or MRI scans of the chest, abdomen, pelvis and brain, there was no evidence of metastatic disease as stage IV NSCLC.

Exclusion Criteria

5. Having a measurable disease as defined in RECIST 1.1, at least one lesion is suitable as a target lesion (determined by the investigator / imaging review of the local research center).

4. No more than 28 days before the first study, CT or MRI scan, at least one previous target lesion without radiotherapy (recistv1.1).

5. No previous treatment (chemotherapy, targeted therapy or radiotherapy) for stage III NSCLC.

6. ECoG physical fitness status is 0 or 2 points.

7. Life expectancy is at least 12 weeks.

8. No antiangiogenic drugs or PARP inhibitors have been used in previous treatment;

9. All acute toxic reactions caused by previous anti-tumor treatment or surgery are relieved before the screening period

(except for hair loss and other toxicity that the researchers believe does not pose a safety risk to the subject).

11. No blood transfusion and blood products were used within 14 days before the first administration, and G-CSF and other hematopoietic stimulating factors were not used for correction.

12. Before the first drug study, the laboratory test values meet the following conditions:

1. Blood routine:

White blood cell count (WBC) ≥ 3.0 × 109/L；

Absolute neutrophil count (ANC) ≥ 1.5 × 109/L；

Platelet (PLT) ≥ 100 × 109/L；

Hemoglobin content (Hgb) ≥ 9.0 g / dl;

2. Liver function:

Aspartate aminotransferase (AST) ≤ 2.5xuln in subjects without liver metastasis,

Alanine liver aminotransferase (ALT) ≤ 2.5x ULN;

ALT and AST of patients with liver metastasis were < 5xuln;

Serum total bilirubin (TBIL) ≤ 1.5xuln (excluding Gilbert syndrome, total bilirubin < 3.0mg/dl); Albumin (ALB) ≥ 3G / dl;

3. Renal function:

Serum creatinine ≤ 1.5xuln or creatinine clearance rate (CrCl) ≥ 40ml / minute

4. Coagulation function:

International standardization ratio (INR) ≤ 1.5, activated partial thromboplastin time (APTT) ≤ 1.5 x ULN;

5. Others:

Lipase ≤ 1.5xuln. If lipase > 1.5xuln but there is no clinical or imaging confirmed pancreatitis, it can be included in the group;

Amylase ≤ 1.5xuln. If amylase > 1.5xuln but there is no clinical or imaging confirmed pancreatitis, it can be included in the group.

Alkaline phosphatase (ALP) ≤ 2.5uln, ALP ≤ 5uln in subjects with bone metastasis;

13. For female subjects of childbearing age who are not sterilized surgically, the serum hCG test must be negative and non lactating within 3 days before the first medication. Contraceptive drugs must be used by male subjects within 6 months after the end of the reproductive age;

14. The subjects voluntarily joined the study, with good compliance, safety and survival follow-up.

1. Suffering from small cell lung cancer or mixed tumor with small cell components. Note: subjects with squamous NSCLC are not eligible for pemetrexed containing chemotherapy.

2. Have a history of MDS / AML, current diagnosis or characteristics suggestive of these diseases.

3. Weight loss > 10% (from baseline) has been recorded in the past 3 months.

4. There is a radiotherapy plan, in which the volume (V20) of the whole lung (whole lung v20-gtv) with a total radiation dose of > 20 Gy may exceed that of the lung. 34% of the volume. Note: subjects must be evaluated by a radiation oncologist during screening.

5. received previous chest radiotherapy, including radiotherapy for esophageal, mediastinal or breast cancer.

6. Previous treatment with anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs or drugs targeting another stimulatory or co inhibitory T cell receptor (e.g. CTLA-4, OX-40, CD137).

7. Previous treatment with fluzopari or any other PARP inhibitor.

8. Major surgery (other than vascular access implantation) was performed within 4 weeks before the first administration of the study drug. Note: if the subject has had major surgery or vascular access implantation, he must have fully recovered from therapeutic toxicity and / or complications before starting the study intervention.

9. It is expected that any other form of antitumor treatment will be required during the study period.

10. Have received live vaccine within 30 days before the first administration of the test drug. Examples of live vaccines include, but are not limited to, the following vaccines: measles, mumps, rubella, chickenpox / shingles (varicella), yellow fever, BCG and typhoid vaccines. Since seasonal influenza vaccines for injection are usually inactivated virus vaccines, they are allowed to be used; But intranasal influenza vaccines (e.g., FluMist ®） It is a live attenuated vaccine, so it is not allowed to be used.

11Strong inducers of CYP3A4 (phenobarbital, enzalutamide, phenytoin, rifampicin, rifampicin, rifapentine, carbamazepine, nevirapine and St. John's grass) or medium inducers (e.g. bosentan, faviren and modafinil) that cannot be stopped during the study period are currently being received. Before starting fluzopari treatment, pentobarbital needs a 5-week washout period, and other drugs need a 3-week washout period.

12At present, they are receiving potent inhibitors of cytochrome P450 (CYP) 3A4 (such as itraconazole, telithromycin, clarithromycin, protease inhibitors strengthened with ritonavir or kirostat, indinavir, saquinavir, nefinavir, bosepovir, terapivir) or intermediate inhibitors (such as ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil) that cannot be stopped during the study period. The elution period required before starting fluzopari is 2 weeks.

13 The dose of piroxicam (e.g. at least 2.5 days before or after administration of piroxicam) and other drugs other than piroxicam (at least 2.5 days after administration of NSD).

14 In the judgment of the investigator, resting electrocardiogram (ECG) indicates uncontrolled and potentially reversible heart disease (e.g., unstable ischemia, uncontrolled symptomatic arrhythmia, congestive heart failure, electrolyte disorder, etc.), or the subject has congenital long QT syndrome.

15 Having a diagnosis of immune deficiency or being treated with chronic systemic steroids (more than 10mg prednisone or equivalent per day) or any form of immunosuppressive therapy within 7 days before the first administration of the study drug.

Note: glucocorticoids are permitted for the following indications:

• eye, intranasal or topical use.
• inhalants for the management of asthma or chronic obstructive pulmonary disease.
• systemic physiological corticosteroid replacement therapy for hormone replacement therapy, preventing vomiting, regulating symptoms suspected of immunological etiology, or as a pretreatment of IV contrast agent allergy or chemotherapeutic agent.

16 Active autoimmune diseases requiring systemic treatment (i.e. use of disease regulating drugs, corticosteroids or immunosuppressants) in the past 2 years. Alternative treatment (e.g., thyroxine, insulin or physiological corticosteroid replacement treatment due to adrenal or pituitary insufficiency) is not considered systemic treatment and is allowed.

17 Currently or previously participated in the study of investigational drugs, or used investigational devices within 4 weeks before the first administration of the study intervention. Note: subjects who have entered the follow-up period of the experimental study can participate in this study as long as they are > 4 weeks after the last administration of previous research drugs.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin Medical University Cancer Institute and Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, China

Site Status: RECRUITING

Countries

China

Facility Contacts

Zhanyu Pan, Master

Role: primary

s0010027@163.com

86-13512035574 ext. 1392029

Other Identifiers

E20220325

Identifier Type: -

Identifier Source: org_study_id