MedDataX Logo

Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.

NCT ID: NCT05392062

Last Updated: 2024-12-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

59 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-09

Study Completion Date

2023-04-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Respiratory Insufficiency

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Gas exchange COVID-19 acute respiratory distress syndrome spontaneous breathing Respiratory failure

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Respiratory insufficiency

Subject with respiratory insufficiency

Group Type OTHER

Pathophysiology of gas exchange

Intervention Type OTHER

Exploration of pathophysiology of gas exchange

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pathophysiology of gas exchange

Exploration of pathophysiology of gas exchange

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with a COVID-19 confirmed infection.
* Admission in intensive care unit for an acute respiratory failure requiring oxygen flow above 6l/min by facial mask.
* Presence of an arterial catheter for blood sampling.

Exclusion Criteria

* Patients on mechanical ventilation on admission to the ICU.
* Patients requiring immediate intubation on admission.
* Patients admitted to the ICU for more than 48 hours at the time of inclusion.
* Pulmonary embolism diagnosed before admission to the ICU.
* Minor patients
* Pregnant women
* Patients under curatorship or guardianship
* Persons deprived of liberty by a judicial or administrative decision
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

CHU de Reims

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Damien JOLLY

Reims, , France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PO21075

Identifier Type: -

Identifier Source: org_study_id