REward SYSTem in Autism Spectrum Disorder and Addictive Disorder
NCT ID: NCT05391113
Last Updated: 2024-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
78 participants
INTERVENTIONAL
2023-07-27
2027-01-27
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Autism Spectrum Disorder
Characterized by two main diagnostic criteria: a socio-emotional deficit via a defect in communication and social reciprocity, and a behavioral deficit which manifests itself in repetitive behavioral patterns (stereotypes), restricted interests and/or activities.
MRI
an fMRI measurement of the BOLD physiological signal for sensory responses
EEG
These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.
Food Addictive Disorders
Characterized by regroup substance use disorders and behavioral addictions, are characterized in particular by the repeated occurrence of compulsive behavior and impaired social functioning
MRI
an fMRI measurement of the BOLD physiological signal for sensory responses
EEG
These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.
Healthy volonteers
Adult without neurological and psychiatric history, absence of progressive somatic pathologies or with vital risk.
MRI
an fMRI measurement of the BOLD physiological signal for sensory responses
EEG
These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.
Interventions
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MRI
an fMRI measurement of the BOLD physiological signal for sensory responses
EEG
These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES \>= 18 criteria).
Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk.
For all participants:
* Age greater than or equal to 18 years old
* Without intellectual delay (IQ \> 70).
* Able to understand and apply the instruction when an active task is proposed, according to the estimate of the investigator.
* Free, express, informed and written consent of the participant.
* Participant affiliated to a social security scheme
Exclusion Criteria
* Visual disturbances not corrected or incompatible with MRI.
* Known epilepsy.
* Current substance use disorder with emotional distress/significant impact on functional outcome
* Rare genetic syndrome.
* Contraindications to MRI (other than body circumference)
* For women of childbearing age: negative urine or blood pregnancy test
* Person subject to a measure of judicial protection (safeguard of justice, curatorship, guardianship or family authorization)
18 Years
ALL
Yes
Sponsors
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INSERM UMR-1253, Tours, France
UNKNOWN
University Hospital, Tours
OTHER
Responsible Party
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Principal Investigators
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Frédéric BRIEND, PhD
Role: PRINCIPAL_INVESTIGATOR
University Hospital,Tours -INSERM U1253 iBrain
Locations
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Center-Val de Loire Region Autism Resource Center
Tours, , France
University Addictology Service, Liaison Team and Addictology Care
Tours, , France
University Hospital, Medical Imaging Service
Tours, , France
Countries
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Central Contacts
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Facility Contacts
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Emmanuelle HOUY-DURAND, MD-PhD
Role: primary
Frédéric BRIEND, PhD
Role: backup
Marianne LATINUS, PhD
Role: backup
Laurent BARANTIN, PhD
Role: backup
Emmanuelle HOUY-DURAND, MD-PhD
Role: backup
Paul BRUNAULT, MD-PhD
Role: primary
Paul BRUNAULT, MD-PhD
Role: backup
Jean-Philippe COTTIER, MD-PhD
Role: primary
Jean-Philippe COTTIER, MD-PhD
Role: backup
Other Identifiers
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2022-A01098-35
Identifier Type: REGISTRY
Identifier Source: secondary_id
22-87
Identifier Type: REGISTRY
Identifier Source: secondary_id
DR220016
Identifier Type: -
Identifier Source: org_study_id