Safety and Pharmacokinetics of Tucatinib (MK-7119) in Chinese Participants With Cancer (MK-7119-002)

NCT ID: NCT05382364

Last Updated: 2025-07-04

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-06-29
• Study Completion Date: 2025-12-31

Brief Summary

The primary purpose of this study is to characterize the safety and tolerability of tucatinib (MK-7119) in Chinese participants with human epidermal growth factor receptor 2 positive (HER2+) advanced breast cancer, gastric or gastroesophageal junction adenocarcinoma (GEC), and colorectal cancer.

Conditions

Metastatic HER2+ Advanced Breast Cancer; Breast Neoplasms; Gastric or Gastroesophageal Junction Adenocarcinoma (GEC); Colorectal Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Tucatinib Treatment

Chinese participants with HER2+ advanced breast cancer, gastric or gastroesophageal junction adenocarcinoma, or colorectal cancer receive tucatinib 300 mg by mouth twice daily during 21-day cycles. Treatment continues until there is evidence of unacceptable toxicity or documented progression.

Group Type: EXPERIMENTAL

Tucatinib

Intervention Type: DRUG

Tucatinib 150 mg and 50 mg tablets taken by mouth at a dose of 300 mg twice daily.

Interventions

Tucatinib

Tucatinib 150 mg and 50 mg tablets taken by mouth at a dose of 300 mg twice daily.

Intervention Type: DRUG

Other Intervention Names

MK-7119

Eligibility Criteria

Inclusion Criteria

• Histologically or cytologically confirmed HER2+ advanced breast cancer, gastric or GEC, and colorectal cancer
• Have progressed at least one previous therapeutic regimen and either no longer are candidates for standard therapy, have no standard therapy available, or choose not to pursue standard therapy
• Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) Performance within 7 days prior to allocation
• Has life expectancy >6 months in the opinion of the investigator
• Have measurable disease per Response Evaluation Criteria in Solid Tumours (RECIST) 1.1 as assessed by the local site investigator/radiologist
• Must test negative for hepatitis B surface antigen (HBsAg)
• If there is a history of hepatitis C virus (HCV) infection, has undetectable HCV viral load at screening
• For males, agree to be abstinent from heterosexual intercourse, or agree to use acceptable contraception, for the duration of study and 1 week after
• For females, is not pregnant or breastfeeding AND one of the following applies:
• Is not a woman of childbearing potential (WOCBP)
• Is a WOCBP and uses highly effective contraception and is not pregnant

Exclusion Criteria

• History of prior cancer within <3 year, except for adequately treated basal cell or squamous cell carcinoma of the skin, cervical cancer in situ, or other in situ carcinomas which needs discussion between the investigator and the Sponsor
• Participants with leptomeningeal disease are excluded
• Has symptomatic central nervous system (CNS) metastases
• Has active human immunodeficiency virus (HIV), hepatitis B virus, or HCV infection
• Has had chemotherapy, immunotherapy, radioimmunotherapy, definitive radiation, or biological cancer therapy or treatment with an investigational product within 4 weeks (2 weeks for palliative radiation) before the first dose of study intervention
• Has an active infection requiring therapy
• Has refractory nausea/vomiting, chronic gastrointestinal disease, or significant bowel resection
• Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study
• Has a QTc prolongation
• Has uncontrolled illness including but not limited to ongoing symptomatic congestive heart failure (New York Heart Association [NYHA] Class III or IV heart failure), unstable angina pectoris, cardiac arrhythmia, and psychiatric illness that would limit compliance with study requirements
• Has had major surgery within 4 weeks prior to first dose of study intervention
• Is currently participating in another clinical trial
• Has psychiatric or substance abuse disorder

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pfizer

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, China

Hunan Cancer Hospital

Changsha, Hunan, China

Jilin Cancer Hospital

Changchun, Jilin, China

Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, China

Fudan University Shanghai Cancer Center

Shanghai, , China

Countries

China

Related Links

https://pmiform.com/clinical-trial-info-request?StudyID=MK-7119-002

To obtain contact information for a study center near you, click here.

Other Identifiers

C4251016

Identifier Type: OTHER

Identifier Source: secondary_id

7119-002

Identifier Type: OTHER

Identifier Source: secondary_id

MK-7119-002

Identifier Type: -

Identifier Source: org_study_id