Prescribing Vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients with Postoperative Pain:

NCT ID: NCT05370404

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-30

Study Completion Date

2024-11-29

Brief Summary

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This is a research project in which two standard of care practices will be evaluated to examine the difference in outcomes. The goal is to improve patient care and safety. One group will receive prescriptions for acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), and magnesium. The other group will receive the recommendation to take acetaminophen, NSAIDs, and magnesium as over-the-counter drugs in the same dosage as the prescription group. The same doses and routes for non-opioid medications will be used in both groups.

Detailed Description

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Conditions

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Acute Pain Surgery

Keywords

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Medications after surgery Surveys Acetaminophen NSAIDS Opioids Elective outpatient surgery Magnesium

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Prescription Group for acetaminophen, NSAIDs, and magnesium

Participants will receive prescriptions from the surgical team for non-opioid pain medications to take at home after discharge from surgery.

The non-opioid pain medications will be acetaminophen 1000 milligram (mg) four times a day (qid) for 3 days then as needed (prn) pain, ibuprofen 600 mg qid for 3 days then prn, and magnesium oxide 400 mg daily prn pain.

Group Type ACTIVE_COMPARATOR

Prescription by surgical team

Intervention Type OTHER

The surgical team prescribes medications to the patient

Over the Counter Group

Participants will receive a recommendation from the surgical team to take over-the-counter non-opioid pain medications at home after discharge from surgery.

The non-opioid pain medications will be acetaminophen 1000 mg qid for 3 days then prn pain, ibuprofen 600 mg qid for 3 days then prn, and magnesium oxide 400 mg daily prn pain.

Group Type ACTIVE_COMPARATOR

Recommendation by surgical team

Intervention Type OTHER

The surgical team recommends the patient to take over-the-counter medications

Interventions

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Prescription by surgical team

The surgical team prescribes medications to the patient

Intervention Type OTHER

Recommendation by surgical team

The surgical team recommends the patient to take over-the-counter medications

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Anticipated to be prescribed and use an opioid medication to treat acute pain after elective outpatient surgery

Exclusion Criteria

* Contraindications to taking acetaminophen or NSAIDs
* Significant analgesic medication use before surgery
* Inability to receive emails or phone calls for follow up assessment
* Patients who have reoperation, another surgery, or experience complications within 14 days after surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Mark Bicket, MD, PhD

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mark Bicket, MD

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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University of Michigan

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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HUM00203454

Identifier Type: -

Identifier Source: org_study_id