Control Cohort CTRL COH

NCT ID: NCT05370079

Last Updated: 2026-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

350 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-08

Study Completion Date

2028-08-08

Brief Summary

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Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare disease that could be difficult to diagnose. So it necessary to obtain numerous sample from different disease to develop more specific diagnosis kit It could be possible through the characterisation of new genetic biomarkers.

Detailed Description

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Conditions

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Parkinson's Disease; Amyotrophic Lateral Sclerosis; Glioblastoma; Cancer Without Neurological Disease; Rheumatoid Polyarthritis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Control cohort

Patient with following disease: Parkinson's disease, Amyotrophic lateral sclerosis, Glioblastoma, cancer without neurological disease (pulmonary cancer, breast cancer, ovarian cancer, melanoma, thymoma), rheumatoid arthritis.

Group Type OTHER

Collection of biological sample (blood and/or CSF)

Intervention Type BIOLOGICAL

Blood sample will be collected one time for each patient:

2 \*4ml of blood on dry tube 2 \*4ml of blood on EDTA tube

If cerebrospinal fluid (CSF) has been drawn for diagnosis, remaining sample available will be stored in the control cohort (1 ml).

Interventions

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Collection of biological sample (blood and/or CSF)

Blood sample will be collected one time for each patient:

2 \*4ml of blood on dry tube 2 \*4ml of blood on EDTA tube

If cerebrospinal fluid (CSF) has been drawn for diagnosis, remaining sample available will be stored in the control cohort (1 ml).

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* patient with consent
* patient with following disease: Parkinson's disease, Amyotrophic lateral sclerosis, Glioblastoma, cancer without neurological disease (pulmonary cancer, breast cancer, ovarian cancer, melanoma, thymoma), rheumatoid arthritis.

Exclusion Criteria

* refusal consent
* patient with neurological disorder compatible with paraneoplastic neurological syndrome or auto-immune encephalitis
* patient under guardianship
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jerome Honnorat, Pr

Role: PRINCIPAL_INVESTIGATOR

Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes, Lyon, France

Locations

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Hospices Civils de Lyon

Bron, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Jerome Honnorat, Pr

Role: CONTACT

(33) 4 72 35 78 06

Géraldine Picard, CRA

Role: CONTACT

(33) 4 72 35 58 42

Facility Contacts

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Jerome HONNORAT, Pr

Role: primary

(33) 4 72 35 78 06

Other Identifiers

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69HCL22_0275

Identifier Type: -

Identifier Source: org_study_id

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