Choline Fenofibrate and Carotid Atherosclerosis in Patients With Type 2 Diabetes and Combined Dyslipidemia

NCT ID: NCT05365425

Last Updated: 2024-05-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE4

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-01

Study Completion Date

2026-12-31

Brief Summary

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This is a randomized controlled study to assess the effect of choline fenofibrate compared with policosanol in Korean T2DM patients with asymptomatic atherosclerosis.

Detailed Description

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In patients with type 2 diabetes with atherosclerotic combined dyslipidemia, the effect of choline fenofibrate on the progression of carotid intima media thickness and carotid artery plaque will be evaluated by 3D carotid ultrasound.

Conditions

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Dyslipidemia Atherosclerosis Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Tgfenon

Choline fenofibrate (135mg as fenofibric acid) 1 tablet once daily oral administration regardless of diet

Group Type EXPERIMENTAL

Choline fenofibrate

Intervention Type DRUG

choline fenofibrate 178.8mg (135mg as fenofibric acid)

Policosanol 10

Policosanol 10mg 1 tablet once daily oral administration

Group Type ACTIVE_COMPARATOR

Policosanol

Intervention Type DRUG

policosanol 10mg

Interventions

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Choline fenofibrate

choline fenofibrate 178.8mg (135mg as fenofibric acid)

Intervention Type DRUG

Policosanol

policosanol 10mg

Intervention Type DRUG

Other Intervention Names

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Tgfenon Policosanol 10

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes under treatment with HbA1c 6.0-10.0% at screening visit
* Male or female of 20 years or over
* Mixed dyslipidemia: triglyceride 200\~499 mg/dL, HDL-cholesterol male ≤45 mg/dL or female ≤50 mg/dL
* Identified carotid artery plaque: carotid intima-media thickness (cIMT) ≥ 1.0 mm
* Creatinine ≤1.8 mg/dL

Exclusion Criteria

* Dyslipidemia which requires other therapy: triglyceride ≥500 mg/dL or LDL-cholesterol ≥190 mg/dL
* Uncontrolled hypertension
* Severe renal dysfunction
* GOT/GPT \>120/120 or chronic liver disease
* Pregnant or childbearing woman who does not have enough contraception
* Changes of medication related to chronic diseases (diabetes, hypertension, dyslipidemia, etc.) within 3 months
* Other antiplatlet medication such as cilostazol, clopidogrel (except aspirin)
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Daewon Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role collaborator

Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Soo Lim

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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SNUBH

Seongnam-si, Gyeonggi-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Soo Lim

Role: CONTACT

+82-31-787-7035

Minji Sohn

Role: CONTACT

Facility Contacts

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Soo Lim

Role: primary

01097662706

Other Identifiers

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B-2111-720-003

Identifier Type: -

Identifier Source: org_study_id

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