Use of TENS for the Recovery of Oral Function After Orthognathic Surgery

NCT ID: NCT05362383

Last Updated: 2022-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

47 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-02-01

Study Completion Date

2020-01-15

Brief Summary

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Oral functions of patients are markedly diminished immediately after orthognathic surgery, and novel approaches are needed to accelerate their recovery. The aim of this study is to examine the usefulness of weekly applications of transcutaneous electrical nerve stimulation (TENS) for this purpose, based on evidence of its effectiveness in other types of patients with muscle alterations. The main objective is to determine whether weekly TENS applications can increase the bite force and jaw opening in patients undergoing orthognathic surgery and decrease their pain and inflammation

Detailed Description

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A single-blind randomized clinical trial will be conducted in patients scheduled for orthognathic surgery, divided between experimental and control groups. Participants will be selected by non-probabilistic sampling of consecutive patients until the estimated sample size is reached. All patients have a skeletal and facial deformity amenable to surgery after a pre-surgical orthodontic period. Patients will be randomly assigned to the experimental group for TENS application or the control group for sham-TENS and the researcher responsible for data analyses will be blinded also. Four variables will be measured: Maximum Jaw Opening using a digital dental caliber, Bite force measured using Dental Prescale Fuji® film, Pain using a visual analog scale (VAS) and facial inflammation using a soft ruler adapted to the contour of the patient's face. Data will be gathered from all patients on jaw opening, bite force, inflammation, and pain before surgery and at 7, 14, 21, and 28 days post-surgery, conducting measurements both before and after the TENS/sham-TENS session. TENS will be applied in an identical manner to all patients in both groups and kept in position for the same time period (30 min); however, the device will be not switched on for the control group, and the stimulation intensity will be adjusted for those in the experimental group to the maximum that did not cause discomfort or areas of contraction, maintaining this stimulation intensity and frequency throughout the 30-min session. Each participant will submit to a weekly TENS a weekly TENS or sham-TENS session on the same day of the week during a four-week period

Conditions

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Orthognathic Surgery Physiology Transcutaneous Electric Nerve Stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Experimental group

transcutaneous electrical nerve stimulation (TENS) is applied

Group Type EXPERIMENTAL

transcutaneous electrical nerve stimulation (TENS):Enraf Nonius® S82 model

Intervention Type DEVICE

Will be used TENS device with a maximum frequency of 120 Hz and an intensity range of 0 to 99.5 milliampere. TENS electrodes (diameter 35-52 mm) will be placed bilaterally on mandibular elevator muscles, on the superficial masseter muscle above the gonial angle, and bilaterally on the anterior temporal muscle. The device will be applied in an identical manner to all patients in both groups and kept in position for the same time period (30 min) and for the control group the the device will be not switched on

Control group

no intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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transcutaneous electrical nerve stimulation (TENS):Enraf Nonius® S82 model

Will be used TENS device with a maximum frequency of 120 Hz and an intensity range of 0 to 99.5 milliampere. TENS electrodes (diameter 35-52 mm) will be placed bilaterally on mandibular elevator muscles, on the superficial masseter muscle above the gonial angle, and bilaterally on the anterior temporal muscle. The device will be applied in an identical manner to all patients in both groups and kept in position for the same time period (30 min) and for the control group the the device will be not switched on

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* programing of bimaxillary or mandibular orthognathic surgery
* no previous or concomitant surgery for temporo-mandibular disorders
* no presence of complex syndromes
* no presence of muscle or nervous disorders or receipt of medication for such disorders

Exclusion Criteria

* impossibility to attend follow-up appointments
* refusal of informed consent
Minimum Eligible Age

22 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universidad Complutense de Madrid

OTHER

Sponsor Role lead

Responsible Party

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Alberto Cacho Casado

Associate Professor and Department Chair, Department of Dental Clinical Specialties, Faculty of Odontology, Complutense University, Madrid, Spain

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alberto C Cacho, Prof

Role: PRINCIPAL_INVESTIGATOR

Faculty of Odontology, University Complutense, Madrid

Locations

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Faculty of Odontology, University Complutense

Madrid, , Spain

Site Status

Countries

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Spain

References

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Teng TT, Ko EW, Huang CS, Chen YR. The Effect of early physiotherapy on the recovery of mandibular function after orthognathic surgery for Class III correction: part I--jaw-motion analysis. J Craniomaxillofac Surg. 2015 Jan;43(1):131-7. doi: 10.1016/j.jcms.2014.10.025. Epub 2014 Nov 1.

Reference Type BACKGROUND
PMID: 25439086 (View on PubMed)

Wen-Ching Ko E, Huang CS, Lo LJ, Chen YR. Longitudinal observation of mandibular motion pattern in patients with skeletal Class III malocclusion subsequent to orthognathic surgery. J Oral Maxillofac Surg. 2012 Feb;70(2):e158-68. doi: 10.1016/j.joms.2011.10.002.

Reference Type BACKGROUND
PMID: 22260918 (View on PubMed)

Jung HD, Jung YS, Park JH, Park HS. Recovery pattern of mandibular movement by active physical therapy after bilateral transoral vertical ramus osteotomy. J Oral Maxillofac Surg. 2012 Jul;70(7):e431-7. doi: 10.1016/j.joms.2012.02.033.

Reference Type BACKGROUND
PMID: 22698299 (View on PubMed)

Bell WH, Gonyea W, Finn RA, Storum KA, Johnston C, Throckmorton GS. Muscular rehabilitation after orthognathic surgery. Oral Surg Oral Med Oral Pathol. 1983 Sep;56(3):229-35. doi: 10.1016/0030-4220(83)90001-4.

Reference Type BACKGROUND
PMID: 6579456 (View on PubMed)

Oh DW, Kim KS, Lee GW. The effect of physiotherapy on post-temporomandibular joint surgery patients. J Oral Rehabil. 2002 May;29(5):441-6. doi: 10.1046/j.1365-2842.2002.00850.x.

Reference Type BACKGROUND
PMID: 12028491 (View on PubMed)

Dailey DL, Rakel BA, Vance CGT, Liebano RE, Amrit AS, Bush HM, Lee KS, Lee JE, Sluka KA. Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain. 2013 Nov;154(11):2554-2562. doi: 10.1016/j.pain.2013.07.043. Epub 2013 Jul 27.

Reference Type BACKGROUND
PMID: 23900134 (View on PubMed)

Sato KL, Sanada LS, Rakel BA, Sluka KA. Increasing intensity of TENS prevents analgesic tolerance in rats. J Pain. 2012 Sep;13(9):884-90. doi: 10.1016/j.jpain.2012.06.004. Epub 2012 Aug 1.

Reference Type BACKGROUND
PMID: 22858165 (View on PubMed)

Dowswell T, Bedwell C, Lavender T, Neilson JP. Transcutaneous electrical nerve stimulation (TENS) for pain relief in labour. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007214. doi: 10.1002/14651858.CD007214.pub2.

Reference Type BACKGROUND
PMID: 19370680 (View on PubMed)

Tong KC, Lo SK, Cheing GL. Alternating frequencies of transcutaneous electric nerve stimulation: does it produce greater analgesic effects on mechanical and thermal pain thresholds? Arch Phys Med Rehabil. 2007 Oct;88(10):1344-9. doi: 10.1016/j.apmr.2007.07.017.

Reference Type BACKGROUND
PMID: 17908580 (View on PubMed)

Liebano RE, Rakel B, Vance CGT, Walsh DM, Sluka KA. An investigation of the development of analgesic tolerance to TENS in humans. Pain. 2011 Feb;152(2):335-342. doi: 10.1016/j.pain.2010.10.040. Epub 2010 Dec 8.

Reference Type BACKGROUND
PMID: 21144659 (View on PubMed)

Mendell LM. Constructing and deconstructing the gate theory of pain. Pain. 2014 Feb;155(2):210-216. doi: 10.1016/j.pain.2013.12.010. Epub 2013 Dec 12.

Reference Type BACKGROUND
PMID: 24334188 (View on PubMed)

Iwase M, Ohashi M, Tachibana H, Toyoshima T, Nagumo M. Bite force, occlusal contact area and masticatory efficiency before and after orthognathic surgical correction of mandibular prognathism. Int J Oral Maxillofac Surg. 2006 Dec;35(12):1102-7. doi: 10.1016/j.ijom.2006.08.014. Epub 2006 Nov 9.

Reference Type BACKGROUND
PMID: 17097270 (View on PubMed)

Hidaka O, Iwasaki M, Saito M, Morimoto T. Influence of clenching intensity on bite force balance, occlusal contact area, and average bite pressure. J Dent Res. 1999 Jul;78(7):1336-44. doi: 10.1177/00220345990780070801.

Reference Type BACKGROUND
PMID: 10403461 (View on PubMed)

Matsui Y, Ohno K, Michi K, Suzuki Y, Yamagata K. A computerized method for evaluating balance of occlusal load. J Oral Rehabil. 1996 Aug;23(8):530-5. doi: 10.1111/j.1365-2842.1996.tb00891.x.

Reference Type BACKGROUND
PMID: 8866265 (View on PubMed)

Ohkura K, Harada K, Morishima S, Enomoto S. Changes in bite force and occlusal contact area after orthognathic surgery for correction of mandibular prognathism. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Feb;91(2):141-5. doi: 10.1067/moe.2001.112334.

Reference Type BACKGROUND
PMID: 11174588 (View on PubMed)

Yaedu RYF, Mello MAB, Tucunduva RA, da Silveira JSZ, Takahashi MPMS, Valente ACB. Postoperative Orthognathic Surgery Edema Assessment With and Without Manual Lymphatic Drainage. J Craniofac Surg. 2017 Oct;28(7):1816-1820. doi: 10.1097/SCS.0000000000003850.

Reference Type BACKGROUND
PMID: 28872503 (View on PubMed)

Moran F, Leonard T, Hawthorne S, Hughes CM, McCrum-Gardner E, Johnson MI, Rakel BA, Sluka KA, Walsh DM. Hypoalgesia in response to transcutaneous electrical nerve stimulation (TENS) depends on stimulation intensity. J Pain. 2011 Aug;12(8):929-35. doi: 10.1016/j.jpain.2011.02.352. Epub 2011 Apr 9.

Reference Type BACKGROUND
PMID: 21481649 (View on PubMed)

Throckmorton GS, Ellis E 3rd, Buschang PH. Morphologic and biomechanical correlates with maximum bite forces in orthognathic surgery patients. J Oral Maxillofac Surg. 2000 May;58(5):515-24. doi: 10.1016/s0278-2391(00)90014-4.

Reference Type BACKGROUND
PMID: 10800907 (View on PubMed)

Trawitzki LV, Silva JB, Regalo SC, Mello-Filho FV. Effect of class II and class III dentofacial deformities under orthodontic treatment on maximal isometric bite force. Arch Oral Biol. 2011 Oct;56(10):972-6. doi: 10.1016/j.archoralbio.2011.02.018. Epub 2011 Mar 25.

Reference Type BACKGROUND
PMID: 21440242 (View on PubMed)

Nagai I, Tanaka N, Noguchi M, Suda Y, Sonoda T, Kohama G. Changes in occlusal state of patients with mandibular prognathism after orthognathic surgery: a pilot study. Br J Oral Maxillofac Surg. 2001 Dec;39(6):429-33. doi: 10.1054/bjom.2001.0681.

Reference Type BACKGROUND
PMID: 11735137 (View on PubMed)

Ueki K, Marukawa K, Hashiba Y, Nakagawa K, Degerliyurt K, Yamamoto E. Assessment of the relationship between the recovery of maximum mandibular opening and the maxillomandibular fixation period after orthognathic surgery. J Oral Maxillofac Surg. 2008 Mar;66(3):486-91. doi: 10.1016/j.joms.2007.08.044.

Reference Type BACKGROUND
PMID: 18280381 (View on PubMed)

Oliveira Sierra S, Melo Deana A, Mesquita Ferrari RA, Maia Albarello P, Bussadori SK, Santos Fernandes KP. Effect of low-level laser therapy on the post-surgical inflammatory process after third molar removal: study protocol for a double-blind randomized controlled trial. Trials. 2013 Nov 6;14:373. doi: 10.1186/1745-6215-14-373.

Reference Type BACKGROUND
PMID: 24195796 (View on PubMed)

Heller GZ, Manuguerra M, Chow R. How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance. Scand J Pain. 2016 Oct;13:67-75. doi: 10.1016/j.sjpain.2016.06.012. Epub 2016 Jul 27.

Reference Type BACKGROUND
PMID: 28850536 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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C.P. - C.I. 12/136-E

Identifier Type: -

Identifier Source: org_study_id

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