Effect of a Dietary Supplement on Quality of Life

NCT ID: NCT05323084

Last Updated: 2024-12-16

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-25

Study Completion Date

2022-09-07

Brief Summary

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The purpose of this research study is to evaluate the effect of a combination of 3 food components to improve the quality of life in people who have trouble sleeping. Ten subjects with insomnia will drink 2 ounces of the supplement or a placebo for 1 week and after a 2 weeks washout period, will take the treatment they did not take the first week. Questionnaires to evaluate quality of life, and a sleep study will be done before and after each treatment week.

Detailed Description

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Each participant will be in the study for about 1 month. The questionnaires consist of Chubon Quality of Life Rating, the Multi-dimensional Fatigue Inventory, Insomnia Severity Index, the Epworth Sleepiness, Pittsburgh Sleep Quality Index. Subjects will be screened with a medical questionnaire, vital signs, height, weight, oximetry to identify sleep apnea, a CBC and chemistry panel and the Insomnia severity Index. Weight, vital signs, adverse event questioning, dispensing and collection of test material will be done at each visit. During each treatment week subjects will wear an actigraph, keep a sleep diary and at the beginning and end of each treatment week subjects will have a polysomnography. At the end of each treatment period subjects will have a chemistry panel, a CBC, and a buffy coat will be archived.

Conditions

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Quality of Life

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

1 week of treatment with a three component supplement or a placebo in people with insomina on two occasions separated by a 2-week washout
Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Caregivers Investigators
Liquid that looks and tastes the same, but only one has the three food components. The order in which the subjects get the 3-component supplement and the placebo is randomly assigned and balanced.

Study Groups

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Dietary supplement

Green tea extract 5 grams, Chicory extract 1gram and collagen peptides 5 grams in 60ml with sugar, erythritol and 2% potassium sorbate and 1% flavor

Group Type EXPERIMENTAL

Dietary supplement

Intervention Type DIETARY_SUPPLEMENT

1 week of each intervention at bedtime with a 2-week washout period in between interventions

Placebo

60ml of water, sugar, erythritol, 2% potassium sorbate, and 1% flavor

Group Type PLACEBO_COMPARATOR

Dietary supplement

Intervention Type DIETARY_SUPPLEMENT

1 week of each intervention at bedtime with a 2-week washout period in between interventions

Interventions

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Dietary supplement

1 week of each intervention at bedtime with a 2-week washout period in between interventions

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Placebo

Eligibility Criteria

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Inclusion Criteria

* Healthy men or women \>50 years of age
* Usual bedtime between 9pm and midnight
* Insomnia for \>6months by ICSD-2 criteria
* Insomnia Severity Index score \>10 and Sleep-onset latency or Waking after sleep onset \>30 minutes

Exclusion Criteria

* Have diabetes mellitus
* Taking chronic medication not on a stable dose for \>1month
* Taking sedating or hypnotic medications
* Have a sleep disorder other than insomnia (like sleep apnea) Adults unable to consent Prisoners Pregnant women Individuals not yet adults
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Louisiana State University Health Sciences Center in New Orleans

OTHER

Sponsor Role collaborator

Pennington Biomedical Research Center

OTHER

Sponsor Role lead

Responsible Party

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Frank Greenway

Professor, Chief Medical Officer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Paula R Brantley, PhD

Role: STUDY_CHAIR

Pennington Biomedical Research Center Institutional Review Board

Locations

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Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Related Links

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https://pubmed.ncbi.nlm.nih.gov/11438246/

Chubon Quality of Life Rating,

https://pubmed.ncbi.nlm.nih.gov/11438246/

Validation of the Insomnia Severity Index

https://pubmed.ncbi.nlm.nih.gov/2748771/

Pittsburgh Sleep Quality Index

Other Identifiers

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PBRC 2020-039

Identifier Type: -

Identifier Source: org_study_id