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Natural History and Nonoperative Management of Penetrating Cerebrovascular Injury

NCT ID: NCT05305690

Last Updated: 2022-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-05-01

Study Completion Date

2023-01-03

Brief Summary

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The goal of this study is to evaluate a series of cases of penetrating cerebrovascular injury managed without upfront operation. Investigators focus on patient characteristics, injury details, treatment modalities, serial imaging studies, patient outcomes, and complications. Investigators will compare this patient population to patients managed with upfront operation for context.

Detailed Description

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Penetrating cerebrovascular injuries (PCVIs) are uncommon, with little data to guide management when emergent operative repair is not performed. Investigators hypothesized that PCVIs may be managed with antithrombotic therapy and directed use of endovascular interventions, but that PCVIs may require enhanced surveillance due to a risk of delayed complications. To perform this study, investigators will review patients with penetrating carotid and vertebral artery injuries managed at an urban Level I trauma center from 2016 to 2022. Patients will be included if they underwent initial nonoperative management (NOM). Patient characteristics, injury details, treatments, serial imaging, outcomes, and complications will be assessed in a retrospective manner using chart abstraction. Investigators will briefly compare these patients to those managed with upfront operations for context.

Conditions

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Cerebrovascular Trauma

Keywords

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penetrating cerebrovascular injury nonoperative management penetrating neck trauma natural history antithrombotic therapy case series

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Penetrating cerebrovascular injury, managed nonoperatively

PCVI from penetrating trauma without upfront operation

No intervention

Intervention Type OTHER

This study did is a retrospective case series and does not involve an intervention. Investigators will compare patients managed operatively vs nonoperatively, focused on nonoperative therapy.

Penetrating cerebrovascular injury, managed operatively

No intervention

Intervention Type OTHER

This study did is a retrospective case series and does not involve an intervention. Investigators will compare patients managed operatively vs nonoperatively, focused on nonoperative therapy.

Interventions

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No intervention

This study did is a retrospective case series and does not involve an intervention. Investigators will compare patients managed operatively vs nonoperatively, focused on nonoperative therapy.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Penetrating neck trauma
* Carotid or vertebral artery injury
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Denver Health Medical Center

OTHER

Sponsor Role collaborator

Poudre Valley Health System

OTHER

Sponsor Role lead

Responsible Party

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Cordelie Witt

Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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19-0647

Identifier Type: -

Identifier Source: org_study_id