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Dual-Energy Computed Tomography (DECT) in Acute Neck Infections: Comparison With Magnetic Resonance Imaging (MRI)

NCT ID: NCT05303922

Last Updated: 2022-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-22

Study Completion Date

2026-03-31

Brief Summary

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The purpose of this prospective study is to compare MRI and DECT in imaging acute neck infection. 50 patients suspected for neck infection will undergo both modalities, which will then be compared in terms of depiction of edema, conspicuity of inflammation, and characterization and number of abscesses. We hypothesize that DECT will have diagnostic performance comparable to that of MRI, and superior to that of traditional single-energy CT. This study will yield important new information about the performance of DECT, a novel and rapid method for emergency imaging.

Detailed Description

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Deep neck infections present challenges even in modern medicine, due to complex anatomy and potentially lethal complications. True extent of the infection is difficult to assess clinically. Therefore, medical imaging is useful in determining the exact location and extent of disease. In suspected neck infection, computed tomography (CT) has traditionally been the first-line imaging method. However, magnetic resonance imaging (MRI) provides excellent soft-tissue characterization surpassing that of CT in the initial evaluation of neck infections. Previous studies have shown than MRI is superior to CT in terms of lesion conspicuity and number of affected spaces in neck infections. As an alternative to MRI, dual-energy CT (DECT) could offer improved soft tissue sensitivity compared with traditional single-energy CT. DECT refers to CT imaging carried out with two kinds of spectra of x-ray. In this prospective comparative study, we will recruit emergency patients with suspected neck infection. Neck MRI will be completed as part of standard clinical care, and DECT as part of this research study. After study completion, DECT and MRI will be compared by neuroradiologists, both modalities at separate occasions, blinded to the clinical information and diagnosis as well to the result of the other modality. Clinical care will be based on MRI as is usual practise. Surgical findings will be considered gold standard.

Conditions

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Neck Abscess

Keywords

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Computed tomography Magnetic resonance imaging

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Each patient will be scanned with both DECT and MRI.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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DECT and MRI

Patients will be scanned with both DECT and MRI.

Group Type EXPERIMENTAL

Dual-energy CT

Intervention Type DIAGNOSTIC_TEST

Dual-energy CT

MRI

Intervention Type DIAGNOSTIC_TEST

MRI

Interventions

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Dual-energy CT

Dual-energy CT

Intervention Type DIAGNOSTIC_TEST

MRI

MRI

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Suspicion of acute neck infection as deemed by the referring physician

Exclusion Criteria

* History of a serious adverse reaction to intravenous iodine- or gadolinium-based contrast agent
* Severe kidney dysfunction (eGFR \< 30 mL/min/1.73m2)
* Foreign metallic objects incompatible with MRI in the body
* Inability to give informed consent, as deemed by study physician
* Inability to follow study instructions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Turku University Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Jussi Hirvonen

Radiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jussi Hirvonen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Turku University Hospital

Locations

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Turku University Hospital

Turku, , Finland

Site Status RECRUITING

Countries

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Finland

Central Contacts

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Jussi Hirvonen, MD, PhD

Role: CONTACT

Phone: +35823130000

Email: [email protected]

Facility Contacts

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Jussi Hirvonen, MD, PhD

Role: primary

Other Identifiers

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T257/2021

Identifier Type: -

Identifier Source: org_study_id