Evaluate the Safety and Efficacy of Two Types of Circular Column Modulated Lenses for Delaying the Progression of Myopia

NCT ID: NCT05288335

Last Updated: 2022-12-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2024-12-31

Brief Summary

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Clinical trial to evaluate the safety and effectiveness of two kinds of ring band cylindrical lens in delaying the progression of myopia

Detailed Description

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Two-hundered and forty children aged 6-13 will be recruited and allocated to three groups. Subjects that were randomized to receive Circular cylindrical mirror modulated frame glasses (compact), Circular cylindrical mirror modulated frame glasses (strong defocus) or single vision frame glasses, respectively.

Primary outcome measure ocular axial length and the secondary indicator is spherical equivalent after cycloplegia.

Conditions

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Myopia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Circular cylindrical mirror modulated frame glasses (compact)

Subjects that were randomized to receive the Circular cylindrical mirror modulated frame glasses (compact) throughout the entire course of the study.

Group Type EXPERIMENTAL

Circular cylindrical mirror modulated frame glasses (compact)

Intervention Type DEVICE

Circular cylindrical mirror modulated frame glasses (compact)

Circular cylindrical mirror modulated frame glasses (strong defocus)

Subjects that were randomized to receive the Circular cylindrical mirror modulated frame glasses (strong defocus) throughout the entire course of the study.

Group Type EXPERIMENTAL

Circular cylindrical mirror modulated frame glasses (strong defocus)

Intervention Type DEVICE

Circular cylindrical mirror modulated frame glasses (strong defocus)

single vision frame glasses

Subjects that were randomized to receive the single vision frame glasses throughout the entire course of the study.

Group Type EXPERIMENTAL

single vision frame glasses

Intervention Type DEVICE

single vision frame glasses

Interventions

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Circular cylindrical mirror modulated frame glasses (compact)

Circular cylindrical mirror modulated frame glasses (compact)

Intervention Type DEVICE

Circular cylindrical mirror modulated frame glasses (strong defocus)

Circular cylindrical mirror modulated frame glasses (strong defocus)

Intervention Type DEVICE

single vision frame glasses

single vision frame glasses

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. 6-13 years old;
2. SER: -0.75 to -5.00 dioptres (D). Astigmatism and anisometropia of 1.50 D or less;
3. Monocular best corrected visual acuity (VA) of 1.0 or better;
4. Acceptance of random group allocation and the masked study design
5. Voluntarily participate in the clinical trial and sign the informed consent;

Exclusion Criteria

1. Strabismus.
2. Ocular and systemic abnormalities.
3. Prior experience of myopia control.
Minimum Eligible Age

6 Years

Maximum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tianjin Eye Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Xiaoqin Chen, MD

Role: PRINCIPAL_INVESTIGATOR

Tianjin Eye Hospital

Locations

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Tianjin Eye Hospital

Tianjin, , China

Site Status

Countries

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China

References

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Bao J, Yang A, Huang Y, Li X, Pan Y, Ding C, Lim EW, Zheng J, Spiegel DP, Drobe B, Lu F, Chen H. One-year myopia control efficacy of spectacle lenses with aspherical lenslets. Br J Ophthalmol. 2022 Aug;106(8):1171-1176. doi: 10.1136/bjophthalmol-2020-318367. Epub 2021 Apr 2.

Reference Type BACKGROUND
PMID: 33811039 (View on PubMed)

Muller J, Chen X, Ohlendorf A, Li L, Wahl S. Method comparison and overview of refractive measurements in children: implications for myopia management. BMJ Open Ophthalmol. 2024 Mar 1;9(1):e001322. doi: 10.1136/bmjophth-2023-001322.

Reference Type DERIVED
PMID: 38429067 (View on PubMed)

Other Identifiers

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TianjinEH-myopia progression

Identifier Type: -

Identifier Source: org_study_id