Cannabidiol Effects on Learning and Anxiety

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

EARLY_PHASE1

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-30

Study Completion Date

2026-02-28

Brief Summary

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To examine the extent to which Cannabidiol (CBD) enhances fear conditioning extinction in college undergraduates who show elevated social anxiety. Undergraduates who display elevated social anxiety on standard assessments will be recruited at the University of Connecticut. All participants will be put in a standard fear conditioning paradigm where they are conditioned to fear a face that occasionally is followed by a shock to their wrist. The other face never is paired with a shock. After everybody learns this, half of the participants will receive 600 mg CBD Isolate Gel Capsules one time, and the other half will receive a placebo dose. Participants will then be presented with the faces with no shocks, and the rate and duration of extinction as measured by electrodermal response as well as subjective fear ratings via a visual analogue scale will be examined. It is hypothesized that participants that receive CBD will display enhanced extinction compared to the placebo group, as evidenced by reduced electrodermal response and reduced visual analogue fear ratings.

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Detailed Description

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Conditions

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Anxiety and Fear

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Drug group vs. Placebo group

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

double blind

Study Groups

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Cannabidiol

600 mg Cannabidiol Isolate Gel Capsules / participant. One-time dose.

Group Type EXPERIMENTAL

Cannabidiol Oral Product

Intervention Type DRUG

Participants will receive a one-time dose of 600 mg Cannabidiol Isolate Gel Capsules in the form of six 100mg capsules.

Placebo

Same number of placebo capsules / participant. One-time dose.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Participants will receive a one-time dose of placebo capsules in the form of six capsules.

Interventions

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Cannabidiol Oral Product

Participants will receive a one-time dose of 600 mg Cannabidiol Isolate Gel Capsules in the form of six 100mg capsules.

Intervention Type DRUG

Placebo

Participants will receive a one-time dose of placebo capsules in the form of six capsules.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18-50 years of age

Exclusion Criteria

1. Difficulties seeing a computer screen
2. Anyone currently taking CBD within the last 24 hours.
3. Anyone using any cannabis product within the last 24 hours.
4. Heart problems or heart disease
5. A neurological disorder such as epilepsy, stroke, multiple sclerosis, tumor, vascular malformations, aneurysm
6. Are currently pregnant or breast-feeding

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes