Pharmacokinetic of Posaconazole in Critically Ill Patients

NCT ID: NCT05275179

Last Updated: 2022-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-11

Study Completion Date

2022-11-01

Brief Summary

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The posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial.

Detailed Description

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The posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial. Plasma specimens will be retrieved on consecutive days (max. 7 days) in order to measure posaconazole levels during the treatment episode.

Conditions

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Therapeutic Drug Monitoring Critical Illness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Posaconazole Therapeutic Drug Monitoring

Therapeutic Drug Monitoring of posaconzole is performed by measuring posaconazole concentrations in serum

Posaconazole Therapeutic Drug Monitoring

Intervention Type OTHER

Therapeutic Drug Monitoring is performed by measuring posaconazole concentrations in serum on seven consecutive days (anticipated).

Interventions

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Posaconazole Therapeutic Drug Monitoring

Therapeutic Drug Monitoring is performed by measuring posaconazole concentrations in serum on seven consecutive days (anticipated).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* treatment with intravenous posaconazole
* critically ill patient
* written declaration of consent

Exclusion Criteria

\- no declaration of consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Universitätsklinikum Hamburg-Eppendorf

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dominic Wichmann, Prof

Role: PRINCIPAL_INVESTIGATOR

Universitätsklinikum Hamburg-Eppendorf

Locations

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University Medical Center Hamburg-Eppendorf

Hamburg, , Germany

Site Status

Countries

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Germany

References

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Konig C, Gopfert M, Kluge S, Wichmann D. Posaconazole exposure in critically ill ICU patients: a need for action. Infection. 2023 Dec;51(6):1767-1772. doi: 10.1007/s15010-023-02078-9. Epub 2023 Jul 27.

Reference Type DERIVED
PMID: 37498488 (View on PubMed)

Other Identifiers

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PV7263

Identifier Type: -

Identifier Source: org_study_id

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