ALT Routinely Recorded Remotely: A Comparator Study of Liver Function Tests Using the Tasso+ to Venipuncture.

NCT ID: NCT05259618

Last Updated: 2022-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-16

Study Completion Date

2022-11-30

Brief Summary

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A direct comparison study of blood samples collected using the Tasso+ device and venous blood samples in patients with elevated alanine transaminase (ALT).

Detailed Description

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This is a prospective, non-blinded, multi-center study to be conducted within the USA. This study will consist of a single arm. Blood will be drawn from each subject, using two different collection methods: the Tasso+ device and the conventional venipuncture method. The results will be compared assess correlation between blood collected at home, by the patient, using the Tasso+ device and blood collected in the office using a Vacutainer (SST, Red Top tube) using venipuncture for alanine transaminase (ALT), aspartate aminotransferase (AST) and total bilirubin.

Participants can complete up to 3 visits and will include self-collected blood samples using the Tasso+ device at home on the day of visit 2 and visit 3.

Conditions

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Elevated Alanine Transaminase (ALT)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with elevated alanine transaminase (ALT)

patients with alanine transaminase (ALT) \> 3x upper limit of normal (ULN).

Tasso+ SST

Intervention Type OTHER

alternative site blood sample collection.

Interventions

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Tasso+ SST

alternative site blood sample collection.

Intervention Type OTHER

Other Intervention Names

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Tasso+

Eligibility Criteria

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Inclusion Criteria

1. Subject must be willing and able to provide written informed consent prior to study entry
2. Subject is ≥ 18 years of age.
3. Subject must meet the following criterion:

known recent history of liver function abnormality and requiring follow-up Liver tests (including ALT\>3XULN)
4. Subject must be willing and able to adhere to the assessments, study schedule, prohibitions and restrictions as described in the protocol.
5. Patients may be on any treatment / therapeutic clinical trial as indicated by treating physician

Exclusion Criteria

1. Pregnant or nursing female by self-report.
2. Presents with abnormal skin integrity or atypical skin health within the areas to be tested (upper shoulders).
3. Subjects who have applied lotion to the skin on the shoulder the day of the visit.
4. Patients with hepatic encephalopathy
5. Vulnerable populations (children, prisoners, pregnant women, participants with diminished decision-making capacity, illiterate populations, educationally disadvantaged populations).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Tasso Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Site Status NOT_YET_RECRUITING

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Site Status RECRUITING

EvergreenHealth Research

Kirkland, Washington, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Brook Quist

Role: CONTACT

Phone: (206) 822-4186

Email: [email protected]

Facility Contacts

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Don Morie

Role: primary

Amin Yaqubie

Role: primary

Conner Bentley

Role: primary

References

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Wickremsinhe E, Fantana A, Berthier E, Quist BA, Lopez de Castilla D, Fix C, Chan K, Shi J, Walker MG, Kherani JF, Knoderer H, Regev A, Harding JJ. Standard Venipuncture vs a Capillary Blood Collection Device for the Prospective Determination of Abnormal Liver Chemistry. J Appl Lab Med. 2023 May 4;8(3):535-550. doi: 10.1093/jalm/jfac127.

Reference Type DERIVED
PMID: 36533519 (View on PubMed)

Other Identifiers

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TALT01-20

Identifier Type: -

Identifier Source: org_study_id