AuraClens™ System in Processing of Lipoaspirate for Autologous Fat Grafting to the Breast

NCT ID: NCT05258305

Last Updated: 2023-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-05

Study Completion Date

2024-11-30

Brief Summary

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Prospective, multi-center, non-randomized, open-label, post-market clinical study evaluating adipose graft retention over time from lipoaspirate processed using the AuraGen 1-2-3™ with AuraClens™ Lipoaspirate Wash System.

Detailed Description

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Autologous fat transfer (AFT) is a medical procedure that includes aspirating adipose tissue from one part of the body, and washing, filtering and re-injecting the processed fat tissue into a different part of the body with the primary purpose of adding volume. The AuraGen1-2-3 with AuraClens Lipoaspirate Wash System is designed to be used in the operating room in conjunction with a user-provided liposuction cannular, a vacuum source, and waste canister. The study population will consist of up to 200 subjects in (2) cohorts: 100 subjects undergoing breast reconstruction and 100 subjects undergoing breast augmentation. All subjects will receive autologous lipoaspirate processed with the A123+ AuraClens and will be followed post-procedure at 1-, 3-, 6-, and 12-months. Fat graft retention will be evaluated with 3D imaging using the Canfield Vectra XT imaging system. Patient satisfaction will be measured between baseline and the post-procedure follow-up visits using a breast satisfaction questionnaire.

Conditions

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Breast Fat Grafting Retention

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

This is a non-randomized open-label study with a patient population consisting of up to 200 subjects divided in 2 cohorts with 100 patients each: reconstruction and augmentation.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Augmentation

Subjects undergoing an aesthetic fat grafting procedure to the breast with or without a breast implant.

Group Type OTHER

AuraGen 1-2-3 with AuraClens

Intervention Type DEVICE

Autologous fat transfer (AFT) is a minimally invasive medical procedure that includes aspirating adipose tissue from one part of the body, and washing, filtering and re-injecting the processed fat tissue into a different part of the body with the primary purpose of adding volume. The AuraGen 1-2-3 with AuraClens is a lipoaspirate wash system designed to be used in the operating room in conjunction with a user-provided liposuction cannular, a vacuum source, and waste canister.

Reconstruction

Subjects undergoing reconstructive fat grafting procedure to the breast with or without a breast implant.

Group Type OTHER

AuraGen 1-2-3 with AuraClens

Intervention Type DEVICE

Autologous fat transfer (AFT) is a minimally invasive medical procedure that includes aspirating adipose tissue from one part of the body, and washing, filtering and re-injecting the processed fat tissue into a different part of the body with the primary purpose of adding volume. The AuraGen 1-2-3 with AuraClens is a lipoaspirate wash system designed to be used in the operating room in conjunction with a user-provided liposuction cannular, a vacuum source, and waste canister.

Interventions

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AuraGen 1-2-3 with AuraClens

Autologous fat transfer (AFT) is a minimally invasive medical procedure that includes aspirating adipose tissue from one part of the body, and washing, filtering and re-injecting the processed fat tissue into a different part of the body with the primary purpose of adding volume. The AuraGen 1-2-3 with AuraClens is a lipoaspirate wash system designed to be used in the operating room in conjunction with a user-provided liposuction cannular, a vacuum source, and waste canister.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Female patients \> 22 years and \< 65 years of age.
* Patients with a BMI \< 35.
* Patients undergoing an aesthetic fat grafting procedure to the breast (breast augmentation) with or without a breast implant.
* Patients must be able to provide written informed consent, understand and be willing to comply with study-related procedures and follow-up visits.
* Patients must be non-smokers.
* Patients with available/adequate harvest sites for fat grafting.
* Anticipated harvested fat volume between 200 and 700 cc.
* Anticipated fat injection volume between 50 and 350 cc per breast.
* Anticipated breast implant volume between 200 and 550 cc.
* Patients must agree to maintain their weight (i.e., within 5%) by not making any major changes in diet or lifestyle during the study.


* Female patients \> 18 years and \< 65 years of age.
* Patients with a BMI \< 35.
* Patients undergoing a fat grafting procedure to the breast in a second or third stage of a staged breast reconstruction, with or without a breast implant.
* Patient is at least 1 year post-completion of chemotherapy.
* Patients must be able to provide written informed consent, understand and be willing to comply with study-related procedures and follow-up visits.
* Patients must be non-smokers.
* Patients with available/adequate harvest sites for fat grafting.
* Anticipated harvested fat volume between 200 and 700 cc.
* Anticipated fat injection volume between 50 nd 350cc per breast.
* Anticipated breast implant volume (if applicable) between 200 and 550 cc.
* Patients must agree to maintain their weight (i.e., within 5%) by not making any major changes in diet or lifestyle during the study.

Exclusion Criteria

* Skin rash in the treatment area.
* Patients who smoke or use nicotine products.
* Patients with bleeding disorders or currently taking anticoagulants.
* Patients with history of trauma or surgery to the treatment area.
* Patients with history of breast cancer.
* Active, chronic, or recurrent infection.
* Compromised immune system.
* Hypersensitivity to analgesic agents.
* Co-morbid condition that could limit ability to participate in the study or to comply with follow-up requirements.
* Untreated drug and/or alcohol abuse.
* Pregnant or breastfeeding.
* Any issue that, at the discretion of the Investigator, would contra-indicate the patient's participation.
* Patients who do not wish to have the study area (breast) photographed.

Reconstruction Subjects


* Skin rash in the treatment area.
* Patients who smoke or use nicotine products.
* Patients with bleeding disorders or currently taking anticoagulants.
* Patients undergoing active treatment for breast cancer.
* Active, chronic, or recurrent infection.
* Compromised immune system.
* Hypersensitivity to analgesic agents.
* Co-morbid condition that could limit ability to participate in the study or to comply with follow-up requirements.
* Untreated drug and/or alcohol abuse.
* Pregnant or breastfeeding.
* Any issue that, at the discretion of the Investigator, would contra-indicate the patient's participation.
* Patients who do not wish to have the study area (breast) photographed.
Minimum Eligible Age

22 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Tiger Biosciences, LLC.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Denise Dajles, PhD

Role: STUDY_DIRECTOR

Tiger Biosciences, LLC.

Locations

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Tessler Plastic Surgery

Scottsdale, Arizona, United States

Site Status

Aura Aesthetica, Inc.

Beverly Hills, California, United States

Site Status

Baptist Miami / Miami Cancer Institute

Miami, Florida, United States

Site Status

Meridian Plastic Surgery

Carmel, Indiana, United States

Site Status

Ascentist Plastic Surgery

Overland Park, Kansas, United States

Site Status

Calo Aesthetics

Louisville, Kentucky, United States

Site Status

Dallas Plastic Surgery

Metairie, Louisiana, United States

Site Status

V Plastic Surgery

West Long Branch, New Jersey, United States

Site Status

NYU Langone Plastic Surgery Associates

New York, New York, United States

Site Status

Luxurgery

New York, New York, United States

Site Status

Hunstad Kortesis Bharti Cosmetic Surgery

Huntersville, North Carolina, United States

Site Status

Restora Austin

Austin, Texas, United States

Site Status

Regional Plastic Surgery

Richardson, Texas, United States

Site Status

Dallas Plastic Surgery

University Park, Texas, United States

Site Status

Bellevue Plastic Surgery

Bellevue, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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AUG-002

Identifier Type: -

Identifier Source: org_study_id