A Clinical Trial to Evaluate the Efficacy and Safety of a Spot Stent System Used in Femoropopliteal Arteries.

NCT ID: NCT05246410

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

196 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-17

Study Completion Date

2024-12-30

Brief Summary

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A prospective randomized trial designed to compare the efficacy and safety of spot stent system versus self-expanding peripheral stent system in the endovascular treatment of femoropopliteal arterial stenotic disease.

Detailed Description

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The objective of this clinical investigation is to assess the efficacy and safety of spot stent system ,which is indicated for use in patients with atherosclerotic disease of the superficial femoral artery (SFA) or proximal popliteal arteries and for the treatment of insufficient results after percutaneous transluminal angioplasty.

Conditions

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Peripheral Vascular Disease (PVD) Peripheral Arterial Disease (PAD)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Spot stent system

A system that loaded multi low radial force stents on one catheter.

Group Type EXPERIMENTAL

Spot stent system

Intervention Type DEVICE

Spot stent system designed and produced by Acotec

Self-Expanding peripheral stent system

A conventional stent system that commonly used.

Group Type ACTIVE_COMPARATOR

Self-expanding peripheral stent system

Intervention Type DEVICE

Self-expanding peripheral stent system designed and produced by Ev3, Inc

Interventions

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Spot stent system

Spot stent system designed and produced by Acotec

Intervention Type DEVICE

Self-expanding peripheral stent system

Self-expanding peripheral stent system designed and produced by Ev3, Inc

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years old and ≤80 years old
* Had lower extremity arterial occlusive diseases, and Rutherford classification is 2-5
* Target lesion is in the superficial femoral artery (SFA) and/or proximal popliteal artery (above the knee), located ≥1 cm below the common femoral artery (CFA) bifurcation to the distal segment of the proximal popliteal artery at the superior end of the patella.
* Target lesion had severe stenosis (stenosis degree ≥70%) or occlusion.
* Presence of at least one patent infrapopliteal vessel.
* The length of target lesion ≥10 cm.
* After predilation, the target lesion has \<30% residual stenosis and presence of at least one flow-limiting dissection (by visual estimate).
* Subject (or legal guardian) understands the study requirements and procedures and provides written Informed Consent before any study tests or procedures are performed.

Exclusion Criteria

* The plasma creatinine level is higher than 150 umol/L.
* Thrombolysis or thrombectomy is required.
* The patient had underwent lower-limb arterial surgery or thrombolysis on the target limb within 6 weeks.
* Previously implanted stent in the target lesion.
* The guide wire can not cross the target lesion.
* Angiographic evidence of calcification severe enough that it renders the target lesion non-dilatable.
* Patient has a known allergy to anticoagulant drugs, anti-platelet drugs or contrast medium that cannot be adequately pre-medicated.
* Women who are pregnant or breast-feeding.
* The subjects have participated in other drug property studies or device studies that have not yet completed the main end point.
* Patient has life expectancy of less than 12 months.
* Patient who planned to do above the ankle amputation before the operation.
* Patient who had severe hemorrhage or coagulation disorder which judged by the investigator.
* The investigator think the patient is not suitable for participation in the clinical trial.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Acotec Scientific Co., Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Guo Wei, MD

Role: PRINCIPAL_INVESTIGATOR

Chinese PLA General Hospital

Locations

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Chinese PLA General Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Zhejiang Provincial People'S Hospital

Zhejiang, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Guo Wei, MD

Role: CONTACT

010-66887329

Facility Contacts

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Wei Guo, MD

Role: primary

010-66887329

Jinsong Jiang

Role: primary

Other Identifiers

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Acoart-08

Identifier Type: -

Identifier Source: org_study_id