Safety Evaluation of KX01 Ointment 1% in Japanese Healthy Male Subjects

NCT ID: NCT05245578

Last Updated: 2022-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-16

Study Completion Date

2022-01-12

Brief Summary

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Skin Irritation and Phototoxicity Study of KX01 Ointment 1% in Japanese healthy male subjects

Detailed Description

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A baseline evaluation of the patch sites will be performed immediately prior to application of the patches to ensure that no conditions, markings, or coloration of the skin will interfere with interpretation of the study results.

A total of 4 application sites (2 cm x 2 cm each) will be marked on each subject's back, placing 2 sites for KX01KX2-391 ointment 1% and 2 sites for Placebo vehicle ointment. One set (KX01 ointment 1% IP and Placebo ointment vehicle patches) will be designated for irradiation and the other set will remain non-irradiated under open conditions. The distance between the patches will be no less than one centimeter.

The numbering of the test sites will remain the same throughout the study. The sites will be marked with an indelible, surgical marker.

Conditions

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Healthy Volunteer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Study Groups

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KX01 ointment and Placebo ointment

Group Type EXPERIMENTAL

KX01 ointment 1%

Intervention Type DRUG

A total of 4 application sites (2 cm x 2 cm each) will be marked on each subject's back, placing 2 sites for KX01 ointment 1% and 2 sites for Placebo ointment. One set (KX01 ointment 1% and Placebo ointment patches) will be designated for irradiation and the other set will remain non-irradiated under open conditions.

Placebo ointment

Intervention Type DRUG

A total of 4 application sites (2 cm x 2 cm each) will be marked on each subject's back, placing 2 sites for KX01 ointment 1% and 2 sites for Placebo ointment. One set (KX01 ointment 1% and Placebo ointment patches) will be designated for irradiation and the other set will remain non-irradiated under open conditions.

Interventions

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KX01 ointment 1%

A total of 4 application sites (2 cm x 2 cm each) will be marked on each subject's back, placing 2 sites for KX01 ointment 1% and 2 sites for Placebo ointment. One set (KX01 ointment 1% and Placebo ointment patches) will be designated for irradiation and the other set will remain non-irradiated under open conditions.

Intervention Type DRUG

Placebo ointment

A total of 4 application sites (2 cm x 2 cm each) will be marked on each subject's back, placing 2 sites for KX01 ointment 1% and 2 sites for Placebo ointment. One set (KX01 ointment 1% and Placebo ointment patches) will be designated for irradiation and the other set will remain non-irradiated under open conditions.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy Japanese male adult, whose age 20-65 years old

Exclusion Criteria

* History of photosensitivity or photoallergy
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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PharmaEssentia Japan K.K.

INDUSTRY

Sponsor Role collaborator

PharmaEssentia

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Hisakuni Sekino

Role: PRINCIPAL_INVESTIGATOR

Medical Corporation HOUEIKAI, Sekino Clinical Pharmacology Clinic

Locations

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Medical Corporation HOUEIKAI, Sekino Clinical Pharmacology Clinic

Toshima-ku, Tokyo, Japan

Site Status

Countries

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Japan

Other Identifiers

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B21-101

Identifier Type: -

Identifier Source: org_study_id

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