Prospective Study to Evaluate a Digital Regimen for Fibromyalgia Management

NCT ID: NCT05243511

Last Updated: 2023-06-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

275 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-08

Study Completion Date

2023-05-15

Brief Summary

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PROSPER-FM is a multi-center, randomized, non-significant risk device study to evaluate the safety and efficacy of two digital therapy smartphone applications in participants with fibromyalgia. Eligible participants are randomized (1:1) to either the Digital Acceptance and Commitment Therapy (Digital ACT) group or the Digital Symptom Tracker group and receive assigned therapy for 12 weeks.

Detailed Description

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Conditions

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Fibromyalgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Digital Acceptance and Commitment Therapy (ACT) Arm

Group Type ACTIVE_COMPARATOR

Digital ACT

Intervention Type DEVICE

Participants in this arm receive Digital ACT as well as standard of care.

Digital Symptom Tracker

Group Type ACTIVE_COMPARATOR

Digital Symptom Tracker

Intervention Type OTHER

Participants in this arm complete a digital symptom and function tracker and monitor, are provided access to digital fibromyalgia and health education, and receive standard of care.

Interventions

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Digital ACT

Participants in this arm receive Digital ACT as well as standard of care.

Intervention Type DEVICE

Digital Symptom Tracker

Participants in this arm complete a digital symptom and function tracker and monitor, are provided access to digital fibromyalgia and health education, and receive standard of care.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Participant is 22 to 75 years of age, inclusive
2. Participant has a diagnosis of primary FM as defined by the 2016 American College of Rheumatology Preliminary Diagnostic Criteria for FM
3. Participants with ongoing treatments should be on stable therapy for 30 days prior to screening appointment.
4. Participant is capable of reading and understanding English and has provided written informed consent to participate.

Exclusion Criteria

1. Lifetime history of bipolar or other psychotic disorder
2. Severe depression at screening (measured by BDI-II)
3. The participant is at increased risk of suicide on the basis of the investigator's judgment or the Columbia-Suicide Severity Rating Scale ("C-SSRS")
4. Participant has any other disease or medical condition that, in the opinion of the Investigator or Sponsor, could endanger the participant, interfere with the evaluation of the study device's efficacy or safety, or compromise the participant's ability to comply with/complete the study.
Minimum Eligible Age

22 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Swing Therapeutics, Inc.

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Gendreau, MD

Role: STUDY_CHAIR

Consulting Chief Medical Officer

Lesley Arnold, MD

Role: PRINCIPAL_INVESTIGATOR

Study Principal Investigator

Locations

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Site #37

Covina, California, United States

Site Status

Site #15

Oceanside, California, United States

Site Status

Site #31

San Bernardino, California, United States

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Site #38

Thousand Oaks, California, United States

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Site #36

Tujunga, California, United States

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Site #35

Whittier, California, United States

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Site #13

Orlando, Florida, United States

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Site #33

St. Petersburg, Florida, United States

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Site #25

Atlanta, Georgia, United States

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Site #21

Covington, Louisiana, United States

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Site #20

New Orleans, Louisiana, United States

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Site #22

Prairieville, Louisiana, United States

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Site #39

Chestnut Hill, Massachusetts, United States

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Site #24

Ocean Springs, Mississippi, United States

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Site #34

Brooklyn, New York, United States

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Site #32

Scarsdale, New York, United States

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Site #12

Williamsville, New York, United States

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Site #27

Fargo, North Dakota, United States

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Site #14

Cincinnati, Ohio, United States

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Site #28

Dayton, Ohio, United States

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Site #23

Tulsa, Oklahoma, United States

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Site #16

Allentown, Pennsylvania, United States

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Site #29

Austin, Texas, United States

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Site #26

McKinney, Texas, United States

Site Status

Site #30

Pflugerville, Texas, United States

Site Status

Countries

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United States

References

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Gendreau RM, McCracken LM, Williams DA, Luciano JV, Dai Y, Vega N, Ghalib Z, Guthrie K, Kraus AC, Rosenbluth MJ, Vaughn B, Zomnir JM, Reddy D, Chadwick AL, Clauw DJ, Arnold LM. Self-guided digital behavioural therapy versus active control for fibromyalgia (PROSPER-FM): a phase 3, multicentre, randomised controlled trial. Lancet. 2024 Jul 27;404(10450):364-374. doi: 10.1016/S0140-6736(24)00909-7. Epub 2024 Jul 8.

Reference Type DERIVED
PMID: 38991582 (View on PubMed)

Other Identifiers

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Swing-005

Identifier Type: -

Identifier Source: org_study_id

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