A Study of Tazemetostat on Safety in Participants With Relapsed or Refractory Follicular Lymphoma With Enhancer of Zeste Homolog 2 (EZH2) Gene Mutation in Japan

NCT ID: NCT05228158

Last Updated: 2026-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

145 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-16

Study Completion Date

2028-03-31

Brief Summary

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The primary purpose of the study is to investigate the safety of tazemetostat in participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation under daily clinical practice.

Detailed Description

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Conditions

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Lymphoma, Follicular

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Tazemetostat

Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation will receive Tazemetostat 800 milligram (mg), tablet, orally, twice daily or as per physicians discretion in routine clinical practice. All the participants will be observed for up to Week 52 prospectively.

Tazemetostat

Intervention Type DRUG

Tazemetostat oral tablets.

Interventions

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Tazemetostat

Tazemetostat oral tablets.

Intervention Type DRUG

Other Intervention Names

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Tazverik

Eligibility Criteria

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Inclusion Criteria

1. Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation
2. Participants treated with tazemetostat

Exclusion Criteria

1\. Participants with a history of hypersensitivity to any ingredient of Tazverik
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eisai Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Eisai Trial Site 131

Komaki-shi, Aichi-ken, Japan

Site Status

Eisai Trial Site 199

Konan-shi, Aichi-ken, Japan

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Eisai Trial Site 21

Nagakute-shi, Aichi-ken, Japan

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Eisai Trial Site 106

Nagoya, Aichi-ken, Japan

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Eisai Trial Site 156

Nagoya, Aichi-ken, Japan

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Eisai Trial Site 174

Nagoya, Aichi-ken, Japan

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Eisai Trial Site 91

Nagoya, Aichi-ken, Japan

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Eisai Trial Site 170

Okazaki-shi, Aichi-ken, Japan

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Eisai Trial Site 181

Seto-shi, Aichi-ken, Japan

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Eisai Trial Site 130

Toyohashi, Aichi-ken, Japan

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Eisai Trial Site 226

Toyokawa-shi, Aichi-ken, Japan

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Eisai Trial Site 133

Toyota-shi, Aichi-ken, Japan

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Eisai Trial Site 205

Yatomi-shi, Aichi-ken, Japan

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Eisai Trial Site 240

Akita, Akita, Japan

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Eisai Trial Site 234

Hirosaki-shi, Aomori, Japan

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Eisai Trial Site 96

Hirosaki-shi, Aomori, Japan

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Eisai Trial Site 119

Chiba, Chiba, Japan

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Eisai Trial Site 5

Kashiwa-shi, Chiba, Japan

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Eisai Trial Site 195

Matsudo-shi, Chiba, Japan

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Eisai Trial Site 25

Matsuyama, Ehime, Japan

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Eisai Trial Site 176

Fukuoka, Fukuoka, Japan

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Eisai Trial Site 227

Fukuoka, Fukuoka, Japan

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Eisai Trial Site 46

Fukuoka, Fukuoka, Japan

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Eisai Trial Site 134

Iizuka-shi, Fukuoka, Japan

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Eisai Trial Site 230

Kitakyusyu-shi, Fukuoka, Japan

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Eisai Trial Site 252

Aizuwakayam-shi, Fukushima, Japan

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Eisai Trial Site 82

Iwaki, Fukushima, Japan

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Eisai Trial Site 244

Koriyama-shi, Fukushima, Japan

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Eisai Trial Site 125

Ogaki-shi, Gifi, Japan

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Eisai Trial Site 27

Gifu, Gifu, Japan

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Eisai Trial Site 28

Gifu, Gifu, Japan

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Eisai Trial Site 45

Fujioka-shi, Gunma, Japan

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Eisai Trial Site 224

Maebashi, Gunma, Japan

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Eisai Trial Site 235

Tatebayashi-shi, Gunma, Japan

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Eisai Trial Site 57

Fukuyama-shi, Hiroshima, Japan

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Eisai Trial Site 52

Hiroshima, Hiroshima, Japan

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Eisai Trial Site 222

Asahikawa-shi, Hokkaido, Japan

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Eisai Trial Site 198

Kitami-shi, Hokkaido, Japan

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Eisai Trial Site 71

Kushiro, Hokkaido, Japan

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Eisai Trial Site 167

Sapporo, Hokkaido, Japan

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Eisai Trial Site 183

Sapporo, Hokkaido, Japan

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Eisai Trial Site 212

Akashi-shi, Hyōgo, Japan

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Eisai Trial Site 72

Akashi-shi, Hyōgo, Japan

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Eisai Trial Site 31

Amagasaki-shi, Hyōgo, Japan

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Eisai Trial Site 124

Itami-shi, Hyōgo, Japan

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Eisai Trial Site 238

Kobe, Hyōgo, Japan

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Eisai Trial Site 89

Kobe, Hyōgo, Japan

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Eisai Trial Site 93

Kobe, Hyōgo, Japan

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Eisai Trial Site 44

Nishinomiya-shi, Hyōgo, Japan

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Eisai Trial Site 29

Hitachi-shi, Ibaraki, Japan

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Eisai Trial Site 237

Toride-shi, Ibaraki, Japan

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Eisai Trial Site 105

Takamatsu, Kagawa-ken, Japan

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Eisai Trial Site 118

Kagoshima, Kagoshima-ken, Japan

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Eisai Trial Site 207

Kanoya-shi, Kagoshima-ken, Japan

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Eisai Trial Site 109

Ebina-shi, Kanagawa, Japan

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Eisai Trial Site 17

Kawasaki-shi, Kanagawa, Japan

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Eisai Trial Site 190

Kawasaki-shi, Kanagawa, Japan

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Eisai Trial Site 87

Sagamihara-shi, Kanagawa, Japan

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Eisai Trial Site 177

Yokohama, Kanagawa, Japan

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Eisai Trial Site 43

Yokohama, Kanagawa, Japan

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Eisai Trial Site 169

Yokosuka-shi, Kanagawa, Japan

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Eisai Trial Site 9

Nankoku-shi, Kochi, Japan

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Eisai Trial Site 253

Kumamoto, Kumamoto, Japan

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Eisai Trial Site 55

Kumamoto, Kumamoto, Japan

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Eisai Trial Site 26

Kyoto, Kyoto, Japan

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Eisai Trial Site 4

Kyoto, Kyoto, Japan

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Eisai Trial Site 56

Kyoto, Kyoto, Japan

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Eisai Trial Site 76

Kyoto, Kyoto, Japan

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Eisai Trial Site 122

Matsusaka-shi, Mie-ken, Japan

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Eisai Trial Site 36

Matsusaka-shi, Mie-ken, Japan

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Eisai Trial Site 186

Yokkaichi-shi, Mie-ken, Japan

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Eisai Trial Site 242

Osaki-shi, Miyagi, Japan

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Eisai Trial Site 161

Sendai, Miyagi, Japan

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Eisai Trial Site 189

Nobeoka-shi, Miyazaki, Japan

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Eisai Trial Site 192

Matsumoto-shi, Nagano, Japan

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Eisai Trial Site 208

Matsumoto-shi, Nagano, Japan

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Eisai Trial Site 127

Nagasaki, Nagasaki, Japan

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Eisai Trial Site 251

Kashihara-shi, Nara, Japan

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Eisai Trial Site 2

Maniwa-shi, Okayama-ken, Japan

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Eisai Trial Site 12

Okayama, Okayama-ken, Japan

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Eisai Trial Site 14

Okayama, Okayama-ken, Japan

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Eisai Trial Site 178

Okayama, Okayama-ken, Japan

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Eisai Trial Site 41

Okayama, Okayama-ken, Japan

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Eisai Trial Site 18

Nakagami-gun, Okinawa, Japan

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Eisai Trial Site 204

Okinawa-shi, Okinawa, Japan

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Eisai Trial Site 164

Hirakata-shi, Osaka, Japan

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Eisai Trial Site 49

Izumisano, Osaka, Japan

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Eisai Trial Site 239

Kawachinagano-shi, Osaka, Japan

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Eisai Trial Site 59

Kawachinagano-shi, Osaka, Japan

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Eisai Trial Site 144

Osaka, Osaka, Japan

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Eisai Trial Site 165

Osaka, Osaka, Japan

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Eisai Trial Site 179

Osaka, Osaka, Japan

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Eisai Trial Site 213

Osaka, Osaka, Japan

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Eisai Trial Site 220

Osaka, Osaka, Japan

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Eisai Trial Site 228

Osaka, Osaka, Japan

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Eisai Trial Site 60

Osaka, Osaka, Japan

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Eisai Trial Site 221

Sakai-shi, Osaka, Japan

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Eisai Trial Site 233

Takatsuki-shi, Osaka, Japan

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Eisai Trial Site 98

Toyonaka-shi, Osaka, Japan

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Eisai Trial Site 247

Saga, Saga-ken, Japan

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Eisai Trial Site 254

Ageo-shi, Saitama, Japan

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Eisai Trial Site 148

Hidaka-shi, Saitama, Japan

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Eisai Trial Site 152

Saitama-shi, Saitama, Japan

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Eisai Trial Site 197

Saitama-shi, Saitama, Japan

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Eisai Trial Site 140

Tokorozawa-shi, Saitama, Japan

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Eisai Trial Site 175

Ōtsu, Shiga, Japan

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Eisai Trial Site 223

Iwata-shi, Shizuoka, Japan

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Eisai Trial Site 40

Izunokuni-shi, Shizuoka, Japan

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Eisai Trial Site 88

Shizuoka, Shizuoka, Japan

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Eisai Trial Site 201

Shimotsuke-shi, Tochigi, Japan

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Eisai Trial Site 245

Shimotsuke-shi, Tochigi, Japan

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Eisai Trial Site 243

Komatsushima-shi, Tokushima, Japan

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Eisai Trial Site 101

Tokushima, Tokushima, Japan

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Eisai Trial Site 187

Tokushima, Tokushima, Japan

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Eisai Trial Site 158

Bunkyo-ku, Tokyo, Japan

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Eisai Trial Site 193

Bunkyo-ku, Tokyo, Japan

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Eisai Trial Site 225

Chiyoda-ku, Tokyo, Japan

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Eisai Trial Site 241

Chofu-shi, Tokyo, Japan

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Eisai Trial Site 1

Chuo-ku, Tokyo, Japan

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Eisai Trial Site 107

Edogawa-ku, Tokyo, Japan

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Eisai Trial Site 249

Kita-ku, Tokyo, Japan

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Eisai Trial Site 229

Meguro-ku, Tokyo, Japan

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Eisai Trial Site 50

Minato-ku, Tokyo, Japan

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Eisai Trial Site 24

Shinagawa-Ku, Tokyo, Japan

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Eisai Trial Site 162

Shinjuku-ku, Tokyo, Japan

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Eisai Trial Site 248

Shinjuku-ku, Tokyo, Japan

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Eisai Trial Site 159

Suginami-ku, Tokyo, Japan

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Eisai Trial Site 231

Taito-ku, Tokyo, Japan

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Eisai Trial Site 202

Toshima-ku, Tokyo, Japan

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Eisai Trial Site 83

Yonago-shi, Tottori, Japan

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Eisai Trial Site 188

Toyama, Toyama, Japan

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Eisai Trial Site 246

Toyama, Toyama, Japan

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Eisai Trial Site 142

Tanabe-shi, Wakayama, Japan

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Eisai Trial Site 236

Wakayama, Wakayama, Japan

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Eisai Trial Site 20

Sakata-shi, Yamagata, Japan

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Countries

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Japan

Other Identifiers

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E7438-M081-501

Identifier Type: -

Identifier Source: org_study_id

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