Trial Outcomes & Findings for Home Air Quality Impact for Adults With Asthma (NCT NCT05224076)

Last Updated: 2025-07-29

Results Overview

Number of episodes per day that the residential VOCs exceeded 333 ppb and/or PM2.5 exceeded 15 mg/m3, as measured by the Awair home air quality monitor

Recruitment status

COMPLETED

Target enrollment

64 participants

Primary outcome timeframe

Measured daily for 14 days

Results posted on

2025-07-29

Participant Flow

Participants were recruited from 5/2022 to 2/2023. Eligibility criteria included previous participation in the Global COVID-19 and Asthma Study (GCAS), willingness to be contacted for future research, high use of disinfectant/cleaning products during COVID-19 (≥5 per week), Asthma Control Test score ≤19 or ≥2 asthma exacerbations in the previous 12 months, owned a smartphone, and had Wi-Fi/wireless connection in their home. Non-US residents and non-English speakers were excluded.

Participant milestones

Participant milestones
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Overall Study STARTED	64
Overall Study COMPLETED	40
Overall Study NOT COMPLETED	24

Reasons for withdrawal

Reasons for withdrawal
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Overall Study Lost to Follow-up	24

Baseline Characteristics

Home Air Quality Impact for Adults With Asthma

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults n=64 Participants We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Age, Categorical <=18 years	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	60 Participants n=5 Participants
Age, Categorical >=65 years	4 Participants n=5 Participants
Age, Continuous	44.7 years STANDARD_DEVIATION 13.6 • n=5 Participants
Sex: Female, Male Female	56 Participants n=5 Participants
Sex: Female, Male Male	8 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	3 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	60 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	4 Participants n=5 Participants
Race (NIH/OMB) Asian	2 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	10 Participants n=5 Participants
Race (NIH/OMB) White	44 Participants n=5 Participants
Race (NIH/OMB) More than one race	3 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants
Region of Enrollment United States	64 participants n=5 Participants

PRIMARY outcome

Timeframe: Measured daily for 14 days

Number of episodes per day that the residential VOCs exceeded 333 ppb and/or PM2.5 exceeded 15 mg/m3, as measured by the Awair home air quality monitor

Outcome measures

Outcome measures
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults n=40 Participants We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Episodes Per Day	2.22 Episodes per day Standard Deviation 1.41

PRIMARY outcome

Timeframe: Assessed daily for 14 days

Number of participants completing daily home spirometry over 14 days.

Outcome measures

Outcome measures
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults n=40 Participants We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Home Spirometry Completed	40 participants

SECONDARY outcome

Timeframe: 14 days

Participants were asked one survey item to assess if the various components of the study were well integrated. Response options ranged from 0=Strongly disagree to 4=Strongly agree. The score was multiplied by 25; scores could range from 0-100. A higher score indicated that the study components were well integrated.

Outcome measures

Outcome measures
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults n=40 Participants We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Integration of Study Components	87.2 score on a scale Standard Deviation 20.9

SECONDARY outcome

Timeframe: 14 days

Number of participants completing air quality triggered EMA surveys

Outcome measures

Outcome measures
Measure	A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults n=40 Participants We assessed the feasibility and usability of ecological momentary assessment (EMA) to capture the context of real time behaviors and environmental exposures that impact indoor environments. In addition, we assessed the feasibility and usability of providing participants with a readily available indoor air quality monitor (Awair Omni®) to continuously capture total volatile organic compounds (VOCs) and particulates (PM2.5). This design will allowed us to alert participants of high levels and collect real time data on exposures and asthma symptoms. Daily and exposure-related lung function were measured with a low-cost home spirometer. Finally, we examined the effect of residential environmental exposures that may be related to increased time spent at home due to COVID-19 and the associations between these exposures and asthma control.
Ecological Momentary Assessment (EMA) Surveys	40 Participants

Adverse Events

A Feasibility Study to Capture Residential Environmental Exposures and Asthma Symptoms in Adults

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Barbara Polivka

University of Kansas School of Nursing

Phone: 6142049915

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place