A First-in-human of Multiplle Doses of BB-1705 in Subjects With Locally Advanced/Metastatic Solid Tumors
NCT ID: NCT05217693
Last Updated: 2025-07-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE1
288 participants
INTERVENTIONAL
2022-06-01
2025-12-31
Brief Summary
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Detailed Description
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Phase Ib is a cohort expansion study to explore one or more RP2Ds to further assess safety, tolerability, pharmacokinetics, and preliminary anti-tumor activity. Patients with locally advanced and unresectable or metastatic solid tumors who have progressed on prior lines of standard of care therapies will be enrolled in this study if eligible.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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dose escalation
Drug: BB-1705 BB-1705 will be administered as an intravenous infusion by Q3W for 8cycles
BB-1705
BB-1705 is an ADC consisting of an engineered humanized IgG1κ monoclonal antibody conjugated to the cytotoxic agent eribulin via a cathepsin-cleavable valine-citrulline linker. BB-1705 has a molecular weight of approximately 152 kDa, including two molecules of eribulin via the linker.
cohort expansion
BB-1705 will be administered as an intravenous infusion by Q3W for 8cycles
BB-1705
BB-1705 is an ADC consisting of an engineered humanized IgG1κ monoclonal antibody conjugated to the cytotoxic agent eribulin via a cathepsin-cleavable valine-citrulline linker. BB-1705 has a molecular weight of approximately 152 kDa, including two molecules of eribulin via the linker.
Interventions
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BB-1705
BB-1705 is an ADC consisting of an engineered humanized IgG1κ monoclonal antibody conjugated to the cytotoxic agent eribulin via a cathepsin-cleavable valine-citrulline linker. BB-1705 has a molecular weight of approximately 152 kDa, including two molecules of eribulin via the linker.
Eligibility Criteria
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Inclusion Criteria
2. Adult patients ≥ 18 years at the time of signing ICF.
3. Patient must have a histologically or cytologically confirmed, locally advanced, unresectable, or metastatic solid tumors:
4. At least one measurable lesion as defined per RECIST Version 1.1.
5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
6. Life expectancy ≥12 weeks.
7. Adequate organ function as indicated by the following laboratory values (had not received blood transfusion, EPO, G-CSF, or other medical support within the 14 days before the administration of BB-1705):
8. Women of childbearing potential and males with fertile female partner must be willing to use currently accepted reliable contraception method throughout the treatment period from ICF signed and for at least 6 months following the last dose of BB-1705. These measures include, but are not limited to, oral or implantable injections of hormonal contraceptives; intrauterine birth control ring or placement of IUS intrauterine device); or use of barrier methods such as condoms or septum and spermicide products. Postmenopausal women over 50 years of age must have been amenorrheic for at least 12 months to be considered of non-childbearing potential. Women of childbearing potential must have a negative pregnancy test ≤ 7 days prior to the first dose of investigational product.
Exclusion Criteria
2. Prior history of other malignancies.
3. Not recovered to baseline or ≤ grade 1 adverse events from prior anti-cancer treatment.
4. Major surgery within 4 weeks and minor surgery within 2 weeks before the first dose or not fully recovered from surgery; or surgery planned during the time the patient is expected to participate in the study
5. Grade 2 or higher peripheral neuropathy.
6. Active pneumonitis/interstitial lung disease (ILD), a history of pneumonitis/ILD that required systemic steroids, received radiotherapy to lung field within 12 months before the first dose of study intervention, or current clinically relevant-lung disease
7. Symptomatic or untreated CNS metastases, or those requiring ongoing treatment for CNS metastases, including steroids (\>10 mg of prednisone or 4 mg of dexamethasone) and antiepileptic agents.
8. Any other serious ongoing underlying medical conditions, including but not limited to, uncontrolled diabetes mellitus, active uncontrolled infection, vaccination within 4 weeks, active gastric ulcer, uncontrolled seizures, cerebrovascular incidents within 6 months of study entry, gastrointestinal bleeding within 3 months of study entry, severe signs and symptoms of coagulation and clotting disorders.
9. QTc interval ≥450 ms for male or ≥470 ms for female (Fridericia's formula) and patients with congenital long QT syndrome.
18 Years
78 Years
ALL
No
Sponsors
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Bliss Biopharmaceutical (Hangzhou) Co., Ltd
INDUSTRY
Responsible Party
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Locations
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Beijing Cancer Hospital
Beijing, , China
Hunan Cancer Hospital
Changsha, , China
First affiliated hospital of Gannan medical university
Ganzhou, , China
Bliss Biopharmaceutical Co, Ltd
Hangzhou, , China
Zhejiang University School of Medicine - The First Affiliated Hospital
Hanzhou, , China
Linyi Cancer Hospital
Linyi, , China
Jiangsu Province Hospital
Nanjing, , China
Countries
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Facility Contacts
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Other Identifiers
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BB-1705-101
Identifier Type: -
Identifier Source: org_study_id
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