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Identify Coronavirus Disease by Chest X-ray

NCT ID: NCT05216471

Last Updated: 2022-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-01

Study Completion Date

2023-12-01

Brief Summary

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to identify the diagnostic accuracy of chest X-ray in diagnosis of Coronavirus disease19 .

Detailed Description

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The pandemic related to the coronavirus is now considered one of the deadliest epidemics. The numbers of cases exponentially increased with no specific treatment, creating havoc for the health and financial systems of the world \[1-6\]. Wuhan, the capital city of Hubei in China, reported the earliest cases that were treated as an unusual pneumonia. With the disease progression, the World Health Organization (WHO) announced the presence of several similar cases \[7, 8\]. Researchers revealed that a novel strain of the family Coronaviridae is the pathogen responsible for the respiratory illness of this disease and this is simulating two previous epidemics, namely MERS (Middle Eastern respiratory syndrome) and SARS (severe acute respiratory syndrome). The disease induced by SARS-CoV-2 was labelled as COVID-19 by the International Classification of Diseases (ICD) \[9\]. Chest radiographs are usually of limited value in the diagnosis of early stages especially in mild disease course; however, the CT findings may be present early even before the onset of the symptoms. Chest radiographs is very helpful in the intermediate to advanced stages of COVID-19 with features of acute respiratory distress syndrome (ARDS) as well as the follow-up \[10-11\]. This study to determine the COVID-19 disease course and severity using chest X-ray (CXR) scoring system and correlate these with patients' age, sex, and outcome.

Conditions

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Coronavirus Disease 2019

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Mild illness

individuals who have any of the various signs and symptoms of covid-19 (e.g., fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, loss of taste and smell) but who do not have shortness of breath, dyspnea, or abnormal chest imaging findings .

chest X-ray

Intervention Type RADIATION

Chest Xray : postero-anterior view ,digital high resolution X-ray or ,full inspiratory

Moderate illness

individuals who show evidence of lower respiratory tract disease during clinical assessment or imaging and who have an oxygen saturation (SpO2) ≥94% on room air .

chest X-ray

Intervention Type RADIATION

Chest Xray : postero-anterior view ,digital high resolution X-ray or ,full inspiratory

Severe illness

individuals who have spO2\<94% on room air, a ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2)\<300 mm hg, respiratory frequency\>30 breaths/min, or lung infiltrate \>50%.

chest X-ray

Intervention Type RADIATION

Chest Xray : postero-anterior view ,digital high resolution X-ray or ,full inspiratory

Interventions

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chest X-ray

Chest Xray : postero-anterior view ,digital high resolution X-ray or ,full inspiratory

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* All individuals attending the Radiodiagnosis Department , who had paired posterior-anterior chest radiographs and RT-PCR nasopharyngeal swabs for COVID-19 at the time of initial attendance with moderate to advanced stage.
* The patients have positive finding in the posterior-anterior chest radiographs , multislice computer tomography and RT-PCR nasopharyngeal swabs for COVID-19.
* The patients with positive finding in the laboratory investigation (CBC, CRP ,ESR , S.Ferritin \& D-Dimmer) .
* Patients with positive chest-CT finding and laboratory finding despite of having negative PCR swab

Exclusion Criteria

* Patients exceeding 30 days after positive RT-PCR .
* Patients diagnosed with mediastinal lymphadenopathy , masses ,Tree in bud appearance ,Pneumothorax. Or Cavitation.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Abdelwahab Elsadek Ibrahim

Resident doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nagham Nabil Mahmoud, Professor

Role: STUDY_CHAIR

Radiodiagnosis Department - Faculty of Medicine - Assiut University

Hosameldeen Abozaid Yousef, Associate Professor

Role: STUDY_DIRECTOR

Radiodiagnosis Department - Faculty of Medicine - Assiut University

Aliaa Abd-Raboh Mohamed, Professor

Role: STUDY_DIRECTOR

Department of Chest Diseases Faculty of Medicine - Assiut University

Mohamed abdelwahab Ibrahim, bachelor

Role: PRINCIPAL_INVESTIGATOR

Radiodiagnosis Resident, Assiut Chest Hospital

Locations

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Assiut University

Asyut, , Egypt

Site Status

Countries

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Egypt

References

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Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.

Reference Type BACKGROUND
PMID: 32007143 (View on PubMed)

Custro N, Scafidi V, Borsellino T. [Changes in the thyroid hormone picture that may be found in severely decompensated type II diabetics]. Minerva Med. 1991 Jan-Feb;82(1-2):9-14. Italian.

Reference Type BACKGROUND
PMID: 2000180 (View on PubMed)

Litmanovich DE, Chung M, Kirkbride RR, Kicska G, Kanne JP. Review of Chest Radiograph Findings of COVID-19 Pneumonia and Suggested Reporting Language. J Thorac Imaging. 2020 Nov 1;35(6):354-360. doi: 10.1097/RTI.0000000000000541.

Reference Type BACKGROUND
PMID: 32520846 (View on PubMed)

Cheng VC, Lau SK, Woo PC, Yuen KY. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev. 2007 Oct;20(4):660-94. doi: 10.1128/CMR.00023-07.

Reference Type BACKGROUND
PMID: 17934078 (View on PubMed)

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.

Reference Type BACKGROUND
PMID: 32031570 (View on PubMed)

Other Identifiers

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x-ray in covid19

Identifier Type: -

Identifier Source: org_study_id