TAKE Steps: Motivational Interviewing to Prevent STIs

NCT ID: NCT05215262

Last Updated: 2025-05-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

94 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-03-08

Study Completion Date

2024-06-05

Brief Summary

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This study will consist of a randomized controlled trial of a motivational interviewing intervention for adolescents with diagnosed sexually transmitted infections (STIs). The sessions will provide HIV/STI prevention education, use motivational interviewing (MI) to enhance goal setting, and providing skill building and referral to evidence based STI and HIV prevention strategies Pre-Exposure Prophylaxis (PrEP), condom use, and partner notification.

Detailed Description

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Pilot phase: Pilot testing will occur over a 3-month period to prime intervention for implementation, with the aim of recruiting n=10 pilot participants. Pilot phase participants will follow the same study procedure timeline as participants randomized to the MI intervention arm of the randomized control trial (RCT), excluding the 6-month follow-up visit. Pilot participants will not be followed in the RCT or contribute outcome data. At the end of every intervention visit in the pilot phase (the baseline, 1-week, 1-month and 3-month visits), participants will complete a brief feedback interview to ensure face validity and identify areas needing refinement. Feedback will be incorporated into the study design, with amendments submitted to the Institutional Review Board (IRB) as needed. Data from pilot participants will not be included in analysis of the RCT.

Intervention phase:The RCT will randomize youth with recent STI 2:1 to the TAKE Steps intervention vs a standard of care (SOC) control. Both arms (intervention and SOC) will have data collection visits at the baseline, the 3-month, and the 6-month-follow-up time points. In addition, the intervention group will have intervention sessions at baseline, 1 week, 1 month and 3 months.

The study treatment phase for the RCT will consist of data collection and motivational interviewing sessions over a 6-month period. Intervention sessions will consist of HIV and STI prevention education, motivational interviewing, skill building, and referral to therapy.

All visits can occur in-person or remotely.

Conditions

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Self Efficacy HIV Prevention STI Prevention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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T.A.K.E. Steps Motivational Interviewing Intervention

Four MI intervention sessions, 1:1 with participant and health coach.

Group Type EXPERIMENTAL

Treat Act Know Engage (T.A.K.E.) Steps

Intervention Type BEHAVIORAL

Intervention sessions will consist of psychoeducation, HIV/STI goal identification, referral to HIV testing and PrEP, and communication skill building.

Standard of Care

Standard of Care control visit with primary care physician (PCP)

Group Type ACTIVE_COMPARATOR

Standard or Care

Intervention Type BEHAVIORAL

S.O.C. arm will receive treatment as usual. After the baseline interview, participants will be referred to their PCP for management of any clinical issues that arise. Their clinic visit schedule will follow their clinical needs and recommendations of their clinic provider

Interventions

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Treat Act Know Engage (T.A.K.E.) Steps

Intervention sessions will consist of psychoeducation, HIV/STI goal identification, referral to HIV testing and PrEP, and communication skill building.

Intervention Type BEHAVIORAL

Standard or Care

S.O.C. arm will receive treatment as usual. After the baseline interview, participants will be referred to their PCP for management of any clinical issues that arise. Their clinic visit schedule will follow their clinical needs and recommendations of their clinic provider

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Males or females aged 13 to 19 years.
* History of ≥1 STI in the 30 days prior to recruitment
* Confirmed treatment for a laboratory confirmed diagnosis of Trichomonas vaginalis (via microscopy or nucleic acid amplification test \[NAAT\]), Neisseria gonorrhea (NAAT), Chlamydia trachomatis (NAAT), Treponema pallidum \[via new positive rapid plasmin reagin (RPR) assay\] within the prior 30 days
* Self-reported HIV negative status.
* Able to speak and understand written English

Exclusion Criteria

* Unable to provide informed consent due to intoxication or severe psychological distress.
Minimum Eligible Age

13 Years

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

Children's Hospital of Philadelphia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sarah M Wood, MD, MSHP

Role: PRINCIPAL_INVESTIGATOR

Children's Hospital of Philadelphia

Locations

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Primary Care, CHOP Clinic 3550 Market St

Philadelphia, Pennsylvania, United States

Site Status

CHOP Primary Care, Roxborough

Philadelphia, Pennsylvania, United States

Site Status

CHOP Karabots Pediatric Care Center, West Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

CHOP Primary Care, Cobbs Creek

Philadelphia, Pennsylvania, United States

Site Status

CHOP Primary Care, South Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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K23MH119976-02

Identifier Type: NIH

Identifier Source: secondary_id

View Link

19-016708

Identifier Type: -

Identifier Source: org_study_id

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