Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2021-03-23
2025-07-31
Brief Summary
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Detailed Description
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The hypothesis is that oropharyngeal carcinomas express TAS2Rs and that their stimulation can induce apoptosis. The lower expression of certain TAS2Rs in the tumor cells could represent protection from apoptosis by stimulation with the bitter ligands. Alternatively, it could polymorphisms of the bitter taste receptors, which can influence their function independently of the expression. In order to address the question of general bitter sensitivity in more detail, the investigators are planning to carry out a bitter taste test on the test subjects.
methodology As this is a pilot study, the investigators limit the number of subjects to 10 patients with p-16 positive and negative oropharyngeal squamous cell carcinoma and 10 patients with acute recurrent tonsillitis or other benign pathology in pharynx. The expression analysis is carried out using qPCR and possibly immunohistochemical methods. Taste strips are used for the taste tests.
Cognitive interest The results of this study will provide important insight into the pathophysiology of oropharyngeal cancers and possibly all TAS2R-expressing cancers. In addition, this and further studies can create a theoretical basis for new therapeutic methods for this group of diseases.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
DOUBLE
Study Groups
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Patients
Patients with oropharynx cancer
Biopsy
Biopsy of an oropharynx tumor or of a healthy oropharynx mucosa
Healthy subjects
Patients with non malignant pharynx pathology
Biopsy
Biopsy of an oropharynx tumor or of a healthy oropharynx mucosa
Interventions
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Biopsy
Biopsy of an oropharynx tumor or of a healthy oropharynx mucosa
Eligibility Criteria
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Inclusion Criteria
* signed informed consent for all
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Thomas Hummel
OTHER
Responsible Party
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Thomas Hummel
Director, Interdisciplinary Smell and Taste Centre
Locations
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Smell and Taste Center, University Klinik Dresden
Dresden, Saxony, Germany
Countries
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Facility Contacts
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Other Identifiers
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ENTASTE
Identifier Type: -
Identifier Source: org_study_id
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