Mean Platelet Volume and Its Relation to Risk Stratification of Myelodysplastic Syndromes

NCT ID: NCT05204953

Last Updated: 2022-01-24

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 71 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-10-31
• Study Completion Date: 2015-04-30

Brief Summary

The myelodysplastic syndromes (MDS) are a group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, reduced bone marrow (BM) function, and a genetic instability with enhanced risk to transform to secondary acute myeloid leukemia, AML

Detailed Description

The diagnosis of MDS is an effort that requires clinicians and pathologists to work together. A patient's life, livelihood and outlook can be profoundly affected by the terms used by the treating physician. The typical presentation is unexplained anemia, leukopenia and/or thrombocytopenia, in an older patients (median age ≥ 70 years). However, thrombocytosis may be associated with the 5q-deletion syndrome or in selected patients with refractory anemia with ringed sideroblasts syndrome . The white count may be elevated in MDS / myeloproliferative disorder overlap syndromes particularly in chronic myelomonocytic leukemia, CMML.

MDS remains among the most challenging of the myeloid neoplasms to diagnose and classify, particularly in cases in which the blast percentage is not increased in the peripheral blood or bone marrow. Diagnostic problems can arise when the clinical and laboratory findings suggest MDS, but the morphologic findings are inconclusive; when there is secondary dysplasia caused by nutritional deficiencies, medications, toxins, growth factor therapy, inflammation or infection; or when marrow hypocellularity or myelofibrosis obscures the underlying disease process .

The prognosis of MDS is determined by several factors. Revised International Prognostic Scoring System (IPSS-R) for MDS divides patients into very low, low, intermediate, high and very high risk groups. Five factors (the percentage of bone marrow myeloblasts, the diagnostic cytogenetics, the hemoglobin level, the platelet count and the absolute neutrophilic count) are used to generate a prognostic score .

Conditions

Myelodysplastic Syndromes

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

1

patients diagnosed to have myelodysplastic syndrome

No interventions assigned to this group

2

healthy control subjects

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• All patients diagnosed to have myelodysplastic syndromes

Exclusion Criteria

• no

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Asmaa Nady Hussein

Consultant of Clinical Hematology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

youssreya A Ahmad, MD

Role: STUDY_DIRECTOR

Assiut University

Ahmad F Thabet, MD

Role: STUDY_DIRECTOR

Assiut University

References

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Reference Type: BACKGROUND

PMID: 20573398 (View on PubMed)

Other Identifiers

PVARMDS

Identifier Type: -

Identifier Source: org_study_id