Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease

NCT ID: NCT05204329

Last Updated: 2024-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-24

Study Completion Date

2024-11-08

Brief Summary

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This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops. The study will be conducted at Illinois Eye and Ear Infirmary located at University of Illinois at Chicago. The study will use anterior segment Optical Coherence Tomography (OCT)/Scheimpflug Imaging, esthesiometry, and visual analogue scale (VAS) to assess treatment tolerability.

Detailed Description

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The "Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease" study is designed to evaluate the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops in patients with chronic ocular surface disease through a dose-escalation study under a 28-day topical application protocol, and also obtain a preliminary observation on the following:

1. Incidence of treatment emergent adverse events (TEAE) assessed at 28 days following treatment initiation
2. Proportion of patients with improved corneal epithelial barrier at 28 days compared to baseline
3. Final visual acuity, corneal epithelial thickness, corneal stromal haze, corneal sensation, and treatment tolerability

The objective is to determine the dose of MSC Secretome through a first-in-human study through a dose-escalation strategy targeting a toxicity rate of 33% or less.

Conditions

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Mesenchymal Stromal Cells Cornea Corneal Defect Corneal Epithelium Defect

Keywords

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Mesenchymal Stromal Cells Corneal Defect Corneal Epithelium Defect

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SEQUENTIAL

A longitudinal assessment using a classic dose-escalation study design to evaluate the safety and maximal tolerated dose of topical MSC Secretome eye drops
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Low dose of allogenic MSC drops

Escalating doses of allogenic MSC eye drops will be assigned at the lowest dose level.

Group Type ACTIVE_COMPARATOR

MSC Secretome Eye Drops

Intervention Type BIOLOGICAL

MSC Secretome eye drop will be dispensed.

Medium dose of allogenic MSC drops

Escalating doses of allogenic MSC eye drops will be assigned at the medium dose level.

Group Type ACTIVE_COMPARATOR

MSC Secretome Eye Drops

Intervention Type BIOLOGICAL

MSC Secretome eye drop will be dispensed.

High dose of allogenic MSC drops

Escalating doses of allogenic MSC eye drops will be assigned at the high dose level.

Group Type ACTIVE_COMPARATOR

MSC Secretome Eye Drops

Intervention Type BIOLOGICAL

MSC Secretome eye drop will be dispensed.

Interventions

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MSC Secretome Eye Drops

MSC Secretome eye drop will be dispensed.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Patients 18 years of age or older
* Chronic corneal epithelial disease with fluorescein staining score ≥ 6 by NEI grading scale
* Reduced corneal sensation (≤ 4 cm measured by Cochet Bonnet esthesiometry) in at least one corneal quadrant
* A stable ocular surface with no objective clinical evidence of significant (\> 50%) improvement/worsening of the epithelial disease in the last 30 days
* Epithelial disease refractory to conventional non-surgical treatments (e.g., preservative-free artificial tears, gels or ointments; discontinuation of preserved topical drops; anti-inflammatory therapy)

Exclusion Criteria

* Any active or suspected ocular infection (bacterial, viral, fungal or protozoal).
* Evidence of corneal ulceration with stromal loss \> 10%
* Presence of an epithelial defect ≥1.0 mm in the largest diameter in the affected eye
* Presence of any size epithelial defect that has been persistent for more than 30 days
* Patients unable to discontinue or intermittently remove therapeutic contact lens in the study eye (to apply drops) during the 4-week study period
* History of any ocular surgery (including laser or refractive surgical procedures) in the affected eye within the 3 months prior to study enrollment
* History of chemical injury within the last 6 months prior to study enrollment Known hypersensitivity to one of the components of the study or procedural medications (e.g.,fluorescein)
* History of drug, medication or alcohol abuse or addiction
* Use of any investigational agent within 4 weeks of screening visit
* History of previous enrollment in the MSC Secretome Study at a lower dose
* Participation in another clinical study at the same time as the present study
* Participants who are pregnant at the time of study enrollment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Eye Institute (NEI)

NIH

Sponsor Role collaborator

National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

University of Illinois at Chicago

OTHER

Sponsor Role lead

Responsible Party

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Ali R Djalilian

Professor of Ophthalmology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ali R Djalilian, MD

Role: PRINCIPAL_INVESTIGATOR

University of Illinois at Chicago

Charlotte E Joslin, OD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Illinois at Chicago

Elmer Y Tu, MD

Role: PRINCIPAL_INVESTIGATOR

University of Illinois at Chicago

Locations

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University of Illinois at Chicago

Chicago, Illinois, United States

Site Status

Countries

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United States

References

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Related Links

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https://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/UCM564952.pdf

U.S. Department of Health and Human Services Food and Drug Administration Center for Biologics Evaluation and Research. Considerations for the Design of Early-Phase Clinical Trials of Cellular and Gene Therapy Products.

Other Identifiers

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1UG3EY031809-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2021-0754

Identifier Type: -

Identifier Source: org_study_id