Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA Producing Advanced or Metastatic Cancers

NCT ID: NCT05204147

Last Updated: 2025-09-16

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-06-02
• Study Completion Date: 2026-07-21

Brief Summary

This phase I study tests the safety, side effects, and best dose of Ac225-DOTA-M5A in treating patients with CEA positive colorectal cancer that has spread to other places in the body (advanced). Ac225-DOTA-M5A is a humanized monoclonal anti-CEA antibody, linked to a radioactive agent called actinium 225. M5A attaches to CEA positive cancer cells in a targeted way and delivers actinium 225 to kill them.

Detailed Description

PRIMARY OBJECTIVE:

I. To establish the maximum tolerated dose (MTD) of actinium Ac 225-DOTA-anti-CEA Monoclonal Antibody M5A (225Ac-DOTA-M5A) humanized anti-carcinoembryonic antigen (CEA) antibody when given intravenously and to describe the toxicities at each dose studied.

SECONDARY OBJECTIVES:

I. To begin to evaluate the clinical activity of the agent in metastatic colorectal cancer.

II. To evaluate the organ biodistribution, pharmacokinetics and organ dose estimates of 225Ac-DOTA-M5A.

OUTLINE: This is a dose-escalation study.

Patients receive Ac225-DOTA-M5A intravenously (IV) over 25 minutes on day 1.

After completion of study treatment, patients are followed weekly for 6-10 weeks, and then medical records are reviewed for 6 months.

Conditions

Advanced Cancer; Metastatic Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment (Ac225-DOTA-M5A)

Patients receive Ac225-DOTA-M5A IV over 25 minutes on day 1.

Group Type: EXPERIMENTAL

Actinium Ac 225-DOTA-anti-CEA Monoclonal Antibody M5A

Intervention Type: DRUG

Given IV

Biospecimen Collection

Intervention Type: PROCEDURE

Correlative studies

Interventions

Actinium Ac 225-DOTA-anti-CEA Monoclonal Antibody M5A

Given IV

Intervention Type: DRUG

Biospecimen Collection

Correlative studies

Intervention Type: PROCEDURE

Other Intervention Names

225Ac-DOTA-anti-CEA Monoclonal Antibody M5A; 225Ac-DOTA-M5A Humanized Anti-CEA Antibody; Biological Sample Collection; Biospecimen Collected

Eligibility Criteria

Inclusion Criteria

• Patients must have a histologic diagnosis of a malignancy that expresses CEA. If biopsies were performed at an outside facility, the histology must be reviewed and confirmed by the Department of Pathology at the City of Hope
• Patients must have tumors that produce CEA as documented by either an elevated serum CEA above the institutional limit of normal or by immunohistochemical methods. Positive CEA immunohistochemical staining, for the purposes of this protocol, is graded 0-3 and the percentage of tumor cells positive is estimated. A positive CEA stain is determined if more than 30% of the tumor cells have an intensity of 2+ or greater
• Patients must have an advanced disease for which no standard or effective treatment is available. Patients who refuse a standard but non-curative treatment is available may also be considered
• Karnofsky performance status >= 60% and an estimated survival of at least 3 months
• Patients must be >= 18 years old as phase I data for the antibody is not available for younger patients.
• The effects of Ac-225-DOTA-M5A on the developing fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
• Adequate bone marrow function as evidenced by white blood count (WBC) >= 4000/ul, absolute neutrophil count >= 1500/ul, platelet count >= 125,000/ul are required
• Adequate renal function as evidenced by a creatinine =< 1.5 mg/dl and/or a calculated creatinine clearance >= 60 cc/min
• Adequate liver function as evidenced by bilirubin =< 1.5 mg/dl and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) no greater than 2 times the upper limit of normal. Less than 1/3 of the liver must be estimated to be involved with tumor
• Presence of measurable disease is required for study entry
• All patients must be seen in consultation by City of Hope Radiation Oncology and City of Hope Medical Oncology prior to entry onto this trial
• All subjects must have the ability to understand and the willingness to sign a written informed consent
• Prior radiotherapy, immunotherapy, or chemotherapy must have been completed at least 4 weeks prior to patient entry on this study (6 weeks if treated with mitomycin-c or nitrosoureas) and patients must have recovered from any expected side effects of prior therapy

Exclusion Criteria

• Patients should not have any uncontrolled illness including ongoing or uncontrolled active infection
• Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
• Pregnant women are excluded from this study because Ac225-DOTA-M5A are agents with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with Ac225-DOTA-M5A, breastfeeding should be discontinued if the mother is treated with Ac225-DOTA-M5A
• Patients with recurrent or progressive brain or leptomeningeal involvement with cancer. Patients that have had previous therapies for brain metastasis or leptomeningeal disease with demonstrated response or stable disease at least four weeks after therapy will be eligible for the trial
• Patients who have received previous radiation to > 50% of their bone marrow
• Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

City of Hope Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jeffrey Y Wong

Role: PRINCIPAL_INVESTIGATOR

City of Hope Medical Center

Locations

City of Hope Medical Center

Duarte, California, United States

Site Status: RECRUITING

Countries

United States

Facility Contacts

Jeffrey Y. Wong

Role: primary

jwong@coh.org

626-359-8111

Other Identifiers

NCI-2021-14101

Identifier Type: REGISTRY

Identifier Source: secondary_id

20449

Identifier Type: OTHER

Identifier Source: secondary_id

P30CA033572

Identifier Type: NIH

Identifier Source: secondary_id

View Link

20449

Identifier Type: -

Identifier Source: org_study_id