Trial Outcomes & Findings for Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength (NCT NCT05190120)
NCT ID: NCT05190120
Last Updated: 2025-09-30
Results Overview
Quadriceps strength will be tested with a dynamometer before the nerve block and 20 minutes after the nerve block prior to surgery. The dynamometer measures the strength of the quadriceps muscles in the seated position while pushing against the device. We are trying to measure the effect of both femoral and adductor canal nerve blocks on quadriceps strength.
Recruitment status
COMPLETED
Study phase
PHASE4
Target enrollment
132 participants
Primary outcome timeframe
Baseline and 20 minutes after the block prior to surgery
Results posted on
2025-09-30
Participant Flow
Participant milestones
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
|---|---|---|---|---|
|
Overall Study
STARTED
|
31
|
35
|
33
|
33
|
|
Overall Study
COMPLETED
|
25
|
34
|
30
|
27
|
|
Overall Study
NOT COMPLETED
|
6
|
1
|
3
|
6
|
Reasons for withdrawal
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
|---|---|---|---|---|
|
Overall Study
Lost to follow up for primary outcome measurement d/t lack of time to complete before surgery
|
1
|
1
|
1
|
3
|
|
Overall Study
Lost to Follow-up
|
5
|
0
|
2
|
3
|
Baseline Characteristics
Adductor Canal Block Versus Femoral Block on Pain and Quadriceps Strength
Baseline characteristics by cohort
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
n=26 Participants
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
n=35 Participants
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
n=31 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
n=30 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Total
n=122 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|
|
Age, Continuous
|
39 years
n=5 Participants
|
49 years
n=7 Participants
|
35 years
n=5 Participants
|
33.5 years
n=4 Participants
|
36.5 years
n=21 Participants
|
|
Sex: Female, Male
Female
|
8 Participants
n=5 Participants
|
10 Participants
n=7 Participants
|
14 Participants
n=5 Participants
|
14 Participants
n=4 Participants
|
46 Participants
n=21 Participants
|
|
Sex: Female, Male
Male
|
18 Participants
n=5 Participants
|
25 Participants
n=7 Participants
|
17 Participants
n=5 Participants
|
16 Participants
n=4 Participants
|
76 Participants
n=21 Participants
|
|
Race/Ethnicity, Customized
White
|
19 Participants
n=5 Participants
|
21 Participants
n=7 Participants
|
16 Participants
n=5 Participants
|
24 Participants
n=4 Participants
|
80 Participants
n=21 Participants
|
|
Race/Ethnicity, Customized
Asian
|
4 Participants
n=5 Participants
|
8 Participants
n=7 Participants
|
10 Participants
n=5 Participants
|
5 Participants
n=4 Participants
|
27 Participants
n=21 Participants
|
|
Race/Ethnicity, Customized
Black
|
1 Participants
n=5 Participants
|
1 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
2 Participants
n=21 Participants
|
|
Race/Ethnicity, Customized
Hispanic/Latino
|
2 Participants
n=5 Participants
|
4 Participants
n=7 Participants
|
5 Participants
n=5 Participants
|
1 Participants
n=4 Participants
|
12 Participants
n=21 Participants
|
|
Race/Ethnicity, Customized
Native American or Pacific Islander
|
0 Participants
n=5 Participants
|
1 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
1 Participants
n=21 Participants
|
|
BMI
|
24.3 kg/m^2
n=5 Participants
|
28.3 kg/m^2
n=7 Participants
|
25.4 kg/m^2
n=5 Participants
|
24.4 kg/m^2
n=4 Participants
|
25.3 kg/m^2
n=21 Participants
|
PRIMARY outcome
Timeframe: Baseline and 20 minutes after the block prior to surgeryPopulation: The participants with data available are reported here.
Quadriceps strength will be tested with a dynamometer before the nerve block and 20 minutes after the nerve block prior to surgery. The dynamometer measures the strength of the quadriceps muscles in the seated position while pushing against the device. We are trying to measure the effect of both femoral and adductor canal nerve blocks on quadriceps strength.
Outcome measures
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
n=25 Participants
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
n=34 Participants
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
n=27 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
n=24 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
|---|---|---|---|---|
|
Change in Quadriceps Strength Related to the Nerve Block
|
-0.42 Newtons
Interval -1.2 to 0.23
|
-0.55 Newtons
Interval -1.43 to -0.067
|
-3.19 Newtons
Interval -4.25 to -1.73
|
-0.77 Newtons
Interval -1.63 to 0.0
|
SECONDARY outcome
Timeframe: worse pain in first 24 hoursPopulation: The participants with data available are reported here.
As this is an outpatient surgery, we will collect Numerical Pain Scores from the recovery room medical record after surgery as well as from the patients for the first 24 hours after surgery by contacting them at home the following day. We will evaluate the difference in patient pain scores between the two nerve blocks under study. The highest pain score for the 24-hour post-op period was collected for each participant. The median is reported for all participants. A pain score of 10 represents the worst pain.
Outcome measures
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
n=24 Participants
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
n=32 Participants
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
n=31 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
n=30 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
|---|---|---|---|---|
|
Numerical Pain Score From 0-10
|
4.5 score on a scale
Interval 3.0 to 6.5
|
5 score on a scale
Interval 3.0 to 7.0
|
7 score on a scale
Interval 4.0 to 9.0
|
6.5 score on a scale
Interval 5.0 to 9.0
|
SECONDARY outcome
Timeframe: 8 to 24 hoursPopulation: The participants with data available are reported here.
Patients will be contacted after surgery to determine when the nerve block wore off based on their increase in pain
Outcome measures
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
n=18 Participants
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
n=25 Participants
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
n=29 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
n=28 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
|---|---|---|---|---|
|
Duration of Nerve Block
|
678 minutes
Interval 454.0 to 903.0
|
731 minutes
Interval 566.0 to 896.0
|
889 minutes
Interval 730.0 to 1048.0
|
923 minutes
Interval 755.0 to 1091.0
|
SECONDARY outcome
Timeframe: 2 daysPopulation: The participants with data available are reported here.
Data on the amount of pain medication consumed for the 1st 24 hours after surgery will be collected based on medications that were administered during surgery, in the recovery room and medications that patients took at home after discharge from the recovery room. All pain medications will be converted to morphine equivalence in milligrams and reported that way. The comparison will be the difference in mg morphine equivalence consumption between the two nerve block groups.
Outcome measures
| Measure |
Femoral Block for Knee Arthroscopy/Meniscus Surgery
n=22 Participants
Patients scheduled for knee arthroscopy will have a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
n=32 Participants
Patients scheduled for knee arthroscopy will have an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
Femoral Block for ACL Reconstruction
n=30 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and a femoral nerve block done using 0.5% ropivacaine 20ml before surgery.
|
Adductor Canal Block for ACL Reconstruction
n=30 Participants
Patients scheduled for ACL reconstruction will have a sciatic nerve block and an adductor canal block done using 0.75% ropivacaine 13.3ml before surgery.
|
|---|---|---|---|---|
|
Opioid Consumption Reported at mg of Morphine Equivalence
|
40 Morphine milligram equivalents (MME)
Interval 30.0 to 60.0
|
51.25 Morphine milligram equivalents (MME)
Interval 40.0 to 70.0
|
20 Morphine milligram equivalents (MME)
Interval 10.0 to 40.0
|
20 Morphine milligram equivalents (MME)
Interval 15.0 to 40.0
|
Adverse Events
Femoral Block for Knee Arthroscopy/Meniscus Surgery
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Adductor Canal Block for Knee Arthroscopy/Meniscus Surgery
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Femoral Block for ACL Reconstruction
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Adductor Canal Block for ACL Reconstruction
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Pedram Aleshi
University of California San Francisco
Phone: (415) 271-1627
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place