Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-01

Study Completion Date

2028-01-31

Brief Summary

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The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health. The investigators will further investigate the affect of Beetroot juice on the vascular function of all participants.

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Detailed Description

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African Americans and Hispanic individuals have the highest incidence of type 2 diabetes, which increases their risk of all cardiovascular diseases. One of the hallmarks of type 2 diabetes is vascular dysfunction, caused by a lack of nitric oxide bioavailability. Vascular function and blood flow responses to exercise have been shown to improve after nitrate supplementation (beetroot juice), However, whether nitrate supplementation will improve vascular function in African American and Hispanic individuals remains unknown. The investigators will perform a randomized, placebo-controlled study in healthy African American, Hispanic and Caucasian subjects. They will be studied before and 90 minutes after consuming Beetroot juice (high nitrate supplement) or Placebo, with at least 1-week washout period between the two visits (Kenjale AA et al., J Appl Physiol 2011).

Conditions

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Healthy Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

randomized, cross-over, placebo-controlled trial

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

it will be double blinded

Study Groups

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Beetroot Juice

140 ml of beetroot juice (high nitrate dietary supplement)

Group Type ACTIVE_COMPARATOR

Beetroot juice

Intervention Type DIETARY_SUPPLEMENT

high nitrate supplement

Placebo

Placebo drink looks and tastes like the beetroot juice but has the nitrate removed from the juice.

Group Type PLACEBO_COMPARATOR

Placebo drink

Intervention Type DIETARY_SUPPLEMENT

placebo

Interventions

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Beetroot juice

high nitrate supplement

Intervention Type DIETARY_SUPPLEMENT

Placebo drink

placebo

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women who are either Caucasian American, Hispanic, or non-Hispanic African American

Exclusion Criteria

* Blood pressure higher than or equal to 140/90 mmHg
* BMI \> 35kg/m2
* Have a history of cardiovascular, neurological or vascular diseases
* Take prescription medications
* Are smokers
* Are pregnant

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes