Observational Study of the Performance of Cephen Reagents in the Context of Research Into Lupus Anticoagulants

NCT ID: NCT05172778

Last Updated: 2021-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-30

Study Completion Date

2022-12-31

Brief Summary

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Lupus anticoagulants (are antiphospholipid antibodies (PSA), the screening of which is done by demonstrating prolongation of coagulation times corrected by the intake of phospholipids (PL).

Learned societies (ISTH, CLSI) thus recommend, for the research of LA, to carry out initially two screening tests with a low concentration in PL: a time of diluted Russell viper venom (DRVVT) as well as a time activated partial thromboplastin (TCA). If one of these screening tests is positive, it is recommended to perform a second confirmation test using the same principle (DRVVT or TCA) and containing a higher concentration of PL.

The current LA screening method at the Hematology Laboratory of Strasbourg University Hospital includes: a pair of DRVVT screening / confirmation (STA-Staclot DRVV Screen and Confirm, Diagnostica Stago, France) and a screening TCA (PTT-A , Diagnostica Stago, France).

This study aims to compare with the current method of the investigators a pair of TCA screening / confirmation (Cephen LS / Cephen, Hyphen Biomed, France).

Detailed Description

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Conditions

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Lupus Anticoagulant

Keywords

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Lupus Anticoagulant Coagulation Phospholipid

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Major subject
* blood sample already analyzed in the laboratory as part of the treatment by the reference method
* Patient who did not express his opposition to the reuse of his data and his blood sample for the technical study.

Exclusion Criteria

* Minor patient
* Patient under curatorship, guardianship or legal protection
* Patient who expressed his opposition to the use of his data
* Insufficient sample
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Agathe HERB, PharmD

Role: PRINCIPAL_INVESTIGATOR

Laboratoire d'Hématologie - Hôpitaux Universitaires de Strasbourg

Locations

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Laboratoire d'Hématologie - Hôpitaux Universitaires de Strasbourg

Strasbourg, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Agathe HERB, PharmD

Role: CONTACT

Phone: 33 3 88 12 75 53

Email: [email protected]

Saïd CHAYER, PhD, HDR

Role: CONTACT

Email: [email protected]

Facility Contacts

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Agathe HERB, PharmD

Role: primary

Saïd CHAYER, PhD, HDR

Role: backup

Other Identifiers

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8246

Identifier Type: -

Identifier Source: org_study_id