Radiomic Analysis for Predicting Treatment Response and Clinical Outcomes in Malignancies

NCT ID: NCT05170087

Last Updated: 2023-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-03-02

Study Completion Date

2025-03-31

Brief Summary

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In this study, the investigators aim to undertake a retrospective analysis of CT and MRI scans for patients undergoing radiation treatment to develop radiomic signatures to predict treatment response and clinical outcomes.

Detailed Description

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Imaging in oncology has widespread application with modalities like ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET) having a well-established role particularly in diagnosis, staging, assessment of treatment response, and surveillance. With the applications of radiomics in oncology, the potential of imaging as a non-invasive biomarker in treatment response, as well as genotypic characterization, has been recognized. Radiomics has the potential to tailor way towards precision oncology with the development of biomarkers that can guide personalized treatments. In this study, the investigators aim at developing CT and MRI radiomic signatures as potential biomarkers to predict treatment response and clinical outcomes for patients treated with radiation having breast, brain, head and neck, and gynecological malignancies.

Conditions

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Breast Cancer Head and Neck Cancer Brain Cancer Gynecologic Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Breast malignancies

Those diagnosed with breast malignancies

No interventions assigned to this group

Head and Neck malignancies

Those diagnosed with head and neck malignancies

No interventions assigned to this group

Brain malignancies

Those diagnosed with brain malignancies

No interventions assigned to this group

Gynecological malignancies

Those diagnosed with gynecological malignancies

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Breast, head and neck, brain, and gynecological malignancies
* Treated with radiation at Odette Cancer Centre between 2010 and 2019

Exclusion Criteria

* N/A
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sunnybrook Health Sciences Centre

OTHER

Sponsor Role lead

Responsible Party

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Dr. Gregory Czarnota

Radiation Oncologist and Clinical Scientist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gregory Czarnota, Ph.D. M.D.

Role: PRINCIPAL_INVESTIGATOR

Sunnybrook Health Sciences Centre

Locations

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Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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034-2020

Identifier Type: -

Identifier Source: org_study_id

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