The Correlation Between the Metabolism and the Functional Status of Multiple Organs in the Early Stage of Diquat Poisoning

NCT ID: NCT05168111

Last Updated: 2021-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-12-02

Study Completion Date

2022-06-30

Brief Summary

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Diquat (DQ), as a conductive biocidal herbicide, is classified as medium according to Chinese pesticide toxicity classification standards. Since the sale and use of paraquat are stopped in 2016, incidents of diquat poisoning have begun to increase. Diquat is very toxic to the human body. Mistake of Diquat can cause damage to multiple organs throughout the body. It has a high fatality rate and no specific treatment.The treatment method has become a research hotspot of modern poisoning treatment.

The degree of organ dysfunction caused by DQ poisoning is mainly related to the patient's intake and the distribution of the poison in the human body.So far, the distribution concentration of DQ under the influence of the time gradient in the body and the influence of DQ on the human environment,metabolimics,,immune regulation activity and the comprehensive mechanism of action of various inflammatory factors have not been fully elucidated. Therefore, this research mainly focuses on analyzing the internal environment metabolism research in patients with DQ poisoning, and to conduct exploratory research on the severity of the impact on their organ functions

Detailed Description

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Conditions

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Diquat Poisoning

Keywords

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Diquat Metabolomics Toxicology Multicenter

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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patients of Diquat poisoning

Detect the serum sample

Intervention Type DIAGNOSTIC_TEST

Detect the serum sample

normal persons

Detect the serum sample

Intervention Type DIAGNOSTIC_TEST

Detect the serum sample

Interventions

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Detect the serum sample

Detect the serum sample

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

1.Time from poisoning to hospital admission: within 6 hours, 2 The age is greater than 18 years old, less than 65 years old 3 There is at least one target organ dysfunction 4 Previous physical fitness 5 No bad habits (drug use, alcohol addiction)

Exclusion Criteria

1. Refuse to join this study
2. Missing/incomplete information
3. Pregnant women, vulnerable groups such as those who have no capacity for civil conduct and cannot determine the consent of their attorneys
4. Chronic organ dysfunction (chronic heart insufficiency, chronic respiratory insufficiency, chronic renal insufficiency, chronic Liver insufficiency)
5. Tumors, blood system diseases, various systemic immune diseases
6. Various infectious diseases (various hepatitis, tuberculosis, AIDS)
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yongan Xu

Role: STUDY_DIRECTOR

SAHZU

Locations

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SAHZU

Hanzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yongan Xu, Doctor

Role: CONTACT

Phone: 13757164833

Email: [email protected]

Facility Contacts

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Yongan Xu

Role: primary

Other Identifiers

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2021-1068

Identifier Type: -

Identifier Source: org_study_id