Best Practice Advisory to Initiate High-Intensity Statin Therapy in Patients With Peripheral Artery Disease
NCT ID: NCT05166187
Last Updated: 2024-01-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
152 participants
INTERVENTIONAL
2022-04-20
2023-11-13
Brief Summary
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Detailed Description
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Aim 1: To assess the impact of an automated best practice advisory, deployed as part of the standard hospital discharge workflow within the electronic medical record, on high-intensity statin prescription among hospitalized patients with PAD.
Aim 2: To assess the impact of an automated best practice advisory, deployed as part of the standard hospital discharge workflow within the electronic medical record, on short-term cardiovascular outcomes among hospitalized patients with PAD.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Intervention
Patients randomized to the intervention arm will have a Best Practice Advisory (BPA) displayed as part of the discharge order workflow. This BPA requires clinicians to choose an option before completing the discharge documentation. Options include ordering one of the appropriate statins or documenting that the medication is contraindicated, the patient declined, or the patient does not meet criteria for a high-intensity statin.
Best Practice Advisory
Patients in this arm will have a Best Practice Advisory displayed in the Electronic Medical Record (EMR) as part of the discharge order workflow.
Usual Care
Patients randomized to the usual care arm will have the identical set of windows displayed in the discharge workflow minus the BPA window.
No interventions assigned to this group
Interventions
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Best Practice Advisory
Patients in this arm will have a Best Practice Advisory displayed in the Electronic Medical Record (EMR) as part of the discharge order workflow.
Eligibility Criteria
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Inclusion Criteria
* Inpatient status at the adult hospital at Vanderbilt University Medical Center
* Not currently prescribed a high-intensity statin (atorvastatin 40-80mg daily or rosuvastatin 20-40mg daily)
Exclusion Criteria
* History of statin allergy or intolerance recorded in the EMR
* History of rhabdomyolysis defined by International Classification of Diseases/Current Procedural Terminology (ICD/CPT) codes
* History of hepatitis A, B, or C defined by ICD/CPT codes
* Pregnant
* Aspartate aminotransferase \>120 units/L within 30 days of alert
* Alanine aminotransferase \>165 units/L within 30 days of alert
* Primary hospital diagnosis of acute myocardial infarction defined by ICD/CPT codes
* Primary hospital diagnosis of acute stroke defined by ICD/CPT codes
18 Years
ALL
No
Sponsors
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Vanderbilt University Medical Center
OTHER
Responsible Party
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Aaron W. Aday, MD, MSc
Assistant Professor, Division of Cardiovascular Medicine
Principal Investigators
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Aaron W Aday, MD, MSc
Role: PRINCIPAL_INVESTIGATOR
VUMC Cardiovascular Medicine
Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, United States
Countries
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Other Identifiers
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212294
Identifier Type: -
Identifier Source: org_study_id
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