Consequences of Eccentric Cycling on Exercise-related Neuromuscular Responses and Biomarkers in Breast Cancer Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-22

Study Completion Date

2022-04-28

Brief Summary

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This is a monocentric, prospective and interventional study aimed to investigating the physiological responses of eccentric compared to concentric cycling realized 1) at the same metabolic demand and 2) at the same mechanical power output. In order to compare the physiological responses between these two cycling modalities, 3 cycling sessions should be performed for each patient where concentric one will serve as reference / comparison to the eccentric one:

* Session (a): eccentric cycling
* Session (b): high intensity concentric cycling realized at the same mechanical power output than eccentric cycling
* Session (c): low intensity concentric cycling realized at the same metabolic demand than eccentric cycling The 3 sessions will be performed for each patient and order will be randomized.

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Detailed Description

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For each participant, 10 visits will be realized as followed:

Visit 1: determination of maximal O2 consumption (VO2max) and first familiarization session to eccentric cycling Visits 2, 3 and 4: second, third and fourth eccentric cycling familiarization sessions Visits 5, 7 and 9: cycling sessions (a), (b) and (c) attributed in a random order Visits 6, 8 and 10: post-24h measurements after cycling sessions

Conditions

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Breast Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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eccentric cycling compared to concentric cycling

Every participant will perform the same protocol and will participated to the 3 experimental sessions (a, b and c) of the assigned intervention.

Group Type EXPERIMENTAL

Session (a)

Intervention Type OTHER

Eccentric cycling

Session (b)

Intervention Type OTHER

High intensity concentric cycling realized at the same mechanical power output than eccentric cycling

Session (c)

Intervention Type OTHER

Low intensity concentric cycling realized at the same metabolic demand than eccentric cycling

Interventions

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Session (a)

Eccentric cycling

Intervention Type OTHER

Session (b)

High intensity concentric cycling realized at the same mechanical power output than eccentric cycling

Intervention Type OTHER

Session (c)

Low intensity concentric cycling realized at the same metabolic demand than eccentric cycling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Woman who completed (neo)adjuvant chemotherapy since less than 1 year for a breast cancer
* Woman under hormonotherapy, or menopausal woman, or woman in amenorrhea

Exclusion Criteria

* Pregnant and nursing woman
* psychiatric, musculoskeletal or neurological disorders
* presenting at least one contraindication to the use of the transcranial magnetic stimulation
* presenting at least one contraindication to the realisation of the maximum effort test

Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No