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Serum Procalcitonin and Post-cesarean Wound Infection

NCT ID: NCT05164224

Last Updated: 2021-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2022-03-01

Brief Summary

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serum procalcitonin levels are important during infections and sepsis.The aim of this study is to evaluate the correlation between serum procalcitonin and severity of post cesarean wound infection

Detailed Description

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Bacterial infection is primarily a clinical concept that may require the use of supportive bedside or laboratory tests to confirm or exclude. There are two broad factors that are always necessary to confirm the diagnosis: inflammation or systemic dysfunction and direct or indirect evidence of a compatible bacterial pathogen. Inflammation may be localized or result in a systemic inflammatory response syndrome (SIRS).

Infection handling and prevention are now improving with an effective antibiotic discovery, complete immunization and modern sanitation. However, infection remains the most common cause of morbidity and mortality rate in many health care services in the world.

One of the most often serious complications in surgical procedure is surgical site infection. Surgical site infection (SSI) is defined as the presence of liquid pus or abscess which extends on a wound within 30day (RCOG Press, 2008; Bratzlr et al.,2006). Surgical site infection is diagnosed with clinical and laboratory examination. The diagnosis begins with an inspection to check any pus, abscess or inflammation reaction extends on the surgical site. An open wound is also being checked, as well as pus liquid or abscess that leaks from thewound. Pus or tissue specimen should be taken for culture examination and routine blood count for leucocyte count should be investigated and procalcitonin level Procalcitonin (PCT) and leucocyte count are indicators of systemic infection. Procalcitonin is one of the applicable markers to detect bacterial infection in adults. Plasma PCT level is comparable with specific response of bacterial infection, particularly for invasive or probably-invasive bacteria. High concentration of PCT indicates sepsis, severe sepsis or even septic shock condition. It may also represent another possibility and gives additional information towards conventional clinical data. Some studies state that procalcitonin is better, or at least has the same diagnosis potency with another infection marker such as CRP, leukocytosis and fever

Conditions

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Cesarean Wound Disruption

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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No secondary suture

The participants who will develop post-cesarean surgical site infection and follow-up only antibiotic treatment for their wound care.

No interventions assigned to this group

secondary suture

The participants who will develop post-cesarean surgical site infection and need a secondary suture for their wound care

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients who will develop surgical site infection after their cesarean sections.
* 18-40 years old

Exclusion Criteria

* History of chorioamnionitis, premature rupture of membranes or prolonged rupture of membrane.
* Urinary tract infections.
* Any infectious condition other than surgical site infection.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Menoufia University

OTHER

Sponsor Role lead

Responsible Party

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Mohamed Elsibai Anter

Assistant professor of obstetrics and gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mohamed E Anter, MD

Role: STUDY_DIRECTOR

Menoufia University-Shebin Elkom-Egypt

Locations

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Menoufia University hospital

Shibīn al Kawm, Menoufia, Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Mohamed E Anter, MD

Role: CONTACT

Phone: 01224462910

Email: [email protected]

Facility Contacts

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Mohamed Elsibai Anter, MD

Role: primary

Other Identifiers

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12/2020 BSGN 14

Identifier Type: -

Identifier Source: org_study_id