To Evaluate the Efficacy and Safety of DW1903 in Acute and Chronic Gastritis Patient

NCT ID: NCT05163756

Last Updated: 2021-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

332 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-25

Study Completion Date

2021-05-10

Brief Summary

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A Multi-center, Double-blind, Randomized, Parallel, Active-controlled, Non-inferiority, Phase III Clinical Trial to Evaluate the Efficacy and Safety of DW1903 in Patients with Gastritis

Detailed Description

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Conditions

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Gastritis Acute Gastritis Chronic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators
Double (Participant, Investigator) Double-blind

Study Groups

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DW1903(Test)

once a day, q.d. PO / DW1903 + Placebo of DW1903-R1

Group Type EXPERIMENTAL

DW1903

Intervention Type DRUG

q.d. PO, DW1903 + Placebo of DW1903-R1

DW1903-R1(Reference)

once a day, q.d. PO / Placebo of DW1903 + DW1903-R1

Group Type ACTIVE_COMPARATOR

DW1903-R1

Intervention Type DRUG

q.d. PO, Placebo of DW1903 + DW1903-R1

Interventions

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DW1903

q.d. PO, DW1903 + Placebo of DW1903-R1

Intervention Type DRUG

DW1903-R1

q.d. PO, Placebo of DW1903 + DW1903-R1

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who were diagnosed with acute or chronic gastritis in a gastroscopy performed within 7 days prior to administration of this trial.
* At least one or more erosions have been identified on gastroscopy.
* Patients who decided to voluntarily participate in this trial and agreed in writing.

Exclusion Criteria

* Patients who can not undergo gastroscopy
* Peptic ulcer (except scarring) and reflux esophagitis
* Patients who have had gastric acid suppression surgery or stomach/esophagus surgery (except for simple perforation surgery and appendectomy)
* Patients with a history of gastrointestinal malignancies
* Zollinger-Ellison syndrome patients
* Patient with spontaneous coagulation disorder
* Patients with an allergic or hypersensitive response to a study drug
* Patients with a potential pregnancy.
* Patients who had clinically significant abnormalities in the screening test.
* Pregnant and lactating women
* Those currently taking other study drugs
* patients who were judged to be ineligible for the trial by the principle investigator and the person in charge.
Minimum Eligible Age

19 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Daewon Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Korea University Ansan Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Kim JH, Jung HY, Yoo IK, Park SY, Kim JG, Sung JK, Jang JS, Cheon GJ, Kim KO, Kim TO, Lee ST, Cho KB, Chun HJ, Park JJ, Park MI, Jang JY, Jeon SW, Cho JW, Kang DH, Kim GH, Kim JJ, Kim SG, Kim N, Lee YC, Hong SJ, Kim HS, Lee S, Lee SW. Evaluation of the Efficacy and Safety of DW1903 in Patients with Gastritis: A Randomized, Double-Blind, Noninferiority, Multicenter, Phase 3 study. Gut Liver. 2024 Jan 15;18(1):70-76. doi: 10.5009/gnl220446. Epub 2023 Jun 13.

Reference Type DERIVED
PMID: 37309193 (View on PubMed)

Other Identifiers

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DW1903-301

Identifier Type: -

Identifier Source: org_study_id