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Association Between Renal Reserve Function and Progression of Renal Function to Predict CKD Risk in Thai Elderly

NCT ID: NCT05158959

Last Updated: 2021-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-10-24

Study Completion Date

2022-12-30

Brief Summary

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This study investigates renal functional reserve in elderly.

Detailed Description

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The prevalence of CKD in elder is high as age has been a variable in eGFR equation. eGFR by calculation always declines in parallel with age. The assumption that a persistent over 3 months of eGFR less than 60 mL/min/1.73m2 define CKD with risk of progression and need refer to nephrologist may not necessary true in aging population. We study renal functional reserve in elderly population who risk of CKD progression and ESRD is the highest prevalence in human life cycle and explore whether renal functional reserve can be used as ad additional marker of CKD progression in elderly.

Conditions

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Elder Renal Function Abnormal

Keywords

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Renal functional reserve, CKD progression, Elderly

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patient age \> 60 years at screening
* Patient willing to participate in the study and can provide inform consent
* Patient have residual kidney function ≤ 90 ml/min/1.73m2 by CKD-EPI equation

Exclusion Criteria

* Patient active smoking
* Patient have Charlson comorbidity index \> .....
* Patient active cancer
* Patient contraindications for blood collection
* Patients with a history of hypersensitivity to cimetidine or amino acid IV solution
Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Kearkiat Praditpornsilpa

Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Kearkiat Praditpornsilpa

Bangkok, , Thailand

Site Status RECRUITING

Countries

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Thailand

Facility Contacts

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Kearkiat Praditpornsilpa, MD

Role: primary

Other Identifiers

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IRB NO.527/62

Identifier Type: -

Identifier Source: org_study_id