The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability
NCT ID: NCT05155397
Last Updated: 2024-12-03
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
ACTIVE_NOT_RECRUITING
Total Enrollment
627 participants
Study Classification
OBSERVATIONAL
Study Start Date
2016-04-30
Study Completion Date
2037-12-31
Brief Summary
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The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular system, immune system, and mental performance over the lifespan with a focus on healthy working adults. The Dortmund Vital Study is a multidisciplinary longitudinal study involving the Departments of Ergonomics, Immunology, Psychology and Neurosciences, and Toxicology of the Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo) in Dortmund, Germany, as well as several national and international cooperation partners.
Detailed Description
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The Dortmund Vital Study is designed as a combined cross-sectional and longitudinal study. About 600 subjects aged between 20 and 70 years will participate. A wide range of demographic, psychological, behavioral, sensory, cardiovascular, biochemical, immunological and biochemical data, a comprehensive EEG-based cognitive test battery as well as structural and functional magnetic resonance imaging (MRI) have been included in the study. Specifically, parameters obtained by MRI and EEG-related measures can be evaluated as a function of polygenic scores, metabolic products, concentration of immune cells, immune age and infections, such as Toxoplasmosis or COVID-19 that are largely unexplored. The same is true for environmental and lifestyle factors that impact on brain activity and behavior.
The initial testing has been conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035).
The study will shed light on sources of large inter-individual differences in cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity and healthy aging on the one hand, and on risk factors for cognitive decline, mild cognitive impairment or even dementia on the other.
The initial testing has been conducted between 2016 and 2021 and will be repeated every five years (three follow-up measures until 2035).
The study will shed light on sources of large inter-individual differences in cognitive functioning with increasing age and reveal biological and lifestyle markers contributing to work ability, longevity and healthy aging on the one hand, and on risk factors for cognitive decline, mild cognitive impairment or even dementia on the other.
Conditions
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Age-related Cognitive Decline
Study Design
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Observational Model Type
COHORT
Study Time Perspective
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Blood thinners
* Hormones
* Antihypertensives
* Cholesterol reducers
* Normal or corrected-to-normal vision and hearing
* Sufficient language skills
* Hormones
* Antihypertensives
* Cholesterol reducers
* Normal or corrected-to-normal vision and hearing
* Sufficient language skills
Exclusion Criteria
* Dementia
* Parkinsonism
* Stroke
* Cardiovascular diseases
* Bleeding tendency
* Oncological diseases
* Schizophrenia
* Obsessive-compulsive disorder
* Anxiety disorders
* Severe depression
* Head injuries
* Head surgery
* Head implants
* Eye diseases (cataract, glaucoma, blindness)
* Accidents that limit physical fitness and mobility
* Psychotropic drugs
* Neuroleptics
* Parkinsonism
* Stroke
* Cardiovascular diseases
* Bleeding tendency
* Oncological diseases
* Schizophrenia
* Obsessive-compulsive disorder
* Anxiety disorders
* Severe depression
* Head injuries
* Head surgery
* Head implants
* Eye diseases (cataract, glaucoma, blindness)
* Accidents that limit physical fitness and mobility
* Psychotropic drugs
* Neuroleptics
Minimum Eligible Age
20 Years
Maximum Eligible Age
70 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
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Technical University of Dortmund
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Edmund Wascher, PhD
Role: STUDY_DIRECTOR
Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo)
Locations
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Technical University of Dortmund, Leibniz Research Centre for Working Environment and Human Factors
Dortmund, , Germany
Site Status
Countries
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Germany
References
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Gajewski PD, Getzmann S, Brode P, Burke M, Cadenas C, Capellino S, Claus M, Genc E, Golka K, Hengstler JG, Kleinsorge T, Marchan R, Nitsche MA, Reinders J, van Thriel C, Watzl C, Wascher E. Impact of Biological and Lifestyle Factors on Cognitive Aging and Work Ability in the Dortmund Vital Study: Protocol of an Interdisciplinary, Cross-sectional, and Longitudinal Study. JMIR Res Protoc. 2022 Mar 14;11(3):e32352. doi: 10.2196/32352.
Reference Type
BACKGROUND
Kleinert T, Nash K, Koenig T, Wascher E. Correction: Normative Intercorrelations between EEG Microstate Characteristics. Brain Topogr. 2024 Mar;37(2):270. doi: 10.1007/s10548-023-01012-4. No abstract available.
Reference Type
RESULT
Kleinert T, Nash K, Koenig T, Wascher E. Normative Intercorrelations Between EEG Microstate Characteristics. Brain Topogr. 2024 Mar;37(2):265-269. doi: 10.1007/s10548-023-00988-3. Epub 2023 Jul 14.
Reference Type
RESULT
Kleinert T, Koenig T, Nash K, Wascher E. On the Reliability of the EEG Microstate Approach. Brain Topogr. 2024 Mar;37(2):271-286. doi: 10.1007/s10548-023-00982-9. Epub 2023 Jul 6.
Reference Type
RESULT
Getzmann S, Arnau S, Gajewski PD, Wascher E. Auditory distraction, time perception, and the role of age: ERP evidence from a large cohort study. Neurobiol Aging. 2024 Dec;144:114-126. doi: 10.1016/j.neurobiolaging.2024.09.012. Epub 2024 Sep 20.
Reference Type
RESULT
Getzmann S, Gajewski PD, Schneider D, Wascher E. Resting-state EEG data before and after cognitive activity across the adult lifespan and a 5-year follow-up. Sci Data. 2024 Sep 10;11(1):988. doi: 10.1038/s41597-024-03797-w.
Reference Type
RESULT
Mundorf A, Getzmann S, Gajewski PD, Larra MF, Wascher E, Genc E, Ocklenburg S. Phenotyping in clinical laterality research: a comparison of commonly used methods to determine mixed-handedness and ambidexterity. Laterality. 2024 May;29(3):331-349. doi: 10.1080/1357650X.2024.2370871. Epub 2024 Jul 5.
Reference Type
RESULT
Larra MF, Gajewski PD, Getzmann S, Wascher E, Metzler Y. Stress from early life to adulthood: Is there a protective role of cognitive control? Brain Cogn. 2024 Aug;178:106165. doi: 10.1016/j.bandc.2024.106165. Epub 2024 May 16.
Reference Type
RESULT
Getzmann S, Golka K, Brode P, Reinders J, Kadhum T, Hengstler JG, Wascher E, Gajewski PD. Chronic Toxoplasma gondii Infection Modulates Hearing Ability across the Adult Life Span. Life (Basel). 2024 Jan 29;14(2):194. doi: 10.3390/life14020194.
Reference Type
RESULT
Brode P, Claus M, Gajewski PD, Getzmann S, Wascher E, Watzl C. From Immunosenescence to Aging Types-Establishing Reference Intervals for Immune Age Biomarkers by Centile Estimation. Int J Mol Sci. 2023 Aug 24;24(17):13186. doi: 10.3390/ijms241713186.
Reference Type
RESULT
Gajewski PD, Golka K, Hengstler JG, Kadhum T, Digutsch J, Genc E, Wascher E, Getzmann S. Does physical fitness affect cognitive functions differently across adulthood? An advantage of being older. Front Psychol. 2023 Jun 16;14:1134770. doi: 10.3389/fpsyg.2023.1134770. eCollection 2023.
Reference Type
RESULT
Rieker JA, Gajewski PD, Reales JM, Ballesteros S, Golka K, Hengstler JG, Wascher E, Getzmann S. The impact of physical fitness, social life, and cognitive functions on work ability in middle-aged and older adults. Int Arch Occup Environ Health. 2023 May;96(4):507-520. doi: 10.1007/s00420-022-01943-8. Epub 2022 Dec 16.
Reference Type
RESULT
Akan O, Bierbrauer A, Kunz L, Gajewski PD, Getzmann S, Hengstler JG, Wascher E, Axmacher N, Wolf OT. Chronic stress is associated with specific path integration deficits. Behav Brain Res. 2023 Mar 28;442:114305. doi: 10.1016/j.bbr.2023.114305. Epub 2023 Jan 20.
Reference Type
RESULT
Getzmann S, Arnau S, Gajewski PD, Wascher E. When long appears short: Effects of auditory distraction on event-related potential correlates of time perception. Eur J Neurosci. 2022 Jan;55(1):121-137. doi: 10.1111/ejn.15553. Epub 2021 Dec 14.
Reference Type
RESULT
Getzmann S, Schneider D, Wascher E. Selective spatial attention in lateralized multi-talker speech perception: EEG correlates and the role of age. Neurobiol Aging. 2023 Jun;126:1-13. doi: 10.1016/j.neurobiolaging.2023.02.003. Epub 2023 Feb 14.
Reference Type
RESULT
Wascher E, Sharifian F, Gutberlet M, Schneider D, Getzmann S, Arnau S. Mental chronometry in big noisy data. PLoS One. 2022 Jun 8;17(6):e0268916. doi: 10.1371/journal.pone.0268916. eCollection 2022.
Reference Type
RESULT
Sharifian F, Schneider D, Arnau S, Wascher E. Decoding of cognitive processes involved in the continuous performance task. Int J Psychophysiol. 2021 Sep;167:57-68. doi: 10.1016/j.ijpsycho.2021.06.012. Epub 2021 Jul 1.
Reference Type
RESULT
Getzmann S, Digutsch J, Kleinsorge T. COVID-19 Pandemic and Personality: Agreeable People Are More Stressed by the Feeling of Missing. Int J Environ Res Public Health. 2021 Oct 13;18(20):10759. doi: 10.3390/ijerph182010759.
Reference Type
RESULT
Metzen D, Genc E, Getzmann S, Larra MF, Wascher E, Ocklenburg S. Frontal and parietal EEG alpha asymmetry: a large-scale investigation of short-term reliability on distinct EEG systems. Brain Struct Funct. 2022 Mar;227(2):725-740. doi: 10.1007/s00429-021-02399-1. Epub 2021 Oct 21.
Reference Type
RESULT
Bierbrauer A, Kunz L, Gomes CA, Luhmann M, Deuker L, Getzmann S, Wascher E, Gajewski PD, Hengstler JG, Fernandez-Alvarez M, Atienza M, Cammisuli DM, Bonatti F, Pruneti C, Percesepe A, Bellaali Y, Hanseeuw B, Strange BA, Cantero JL, Axmacher N. Unmasking selective path integration deficits in Alzheimer's disease risk carriers. Sci Adv. 2020 Aug 28;6(35):eaba1394. doi: 10.1126/sciadv.aba1394. eCollection 2020 Aug.
Reference Type
RESULT
Gajewski PD, Hanisch E, Falkenstein M, Thones S, Wascher E. What Does the n-Back Task Measure as We Get Older? Relations Between Working-Memory Measures and Other Cognitive Functions Across the Lifespan. Front Psychol. 2018 Nov 26;9:2208. doi: 10.3389/fpsyg.2018.02208. eCollection 2018.
Reference Type
RESULT
Brode P, Claus M, Gajewski PD, Getzmann S, Golka K, Hengstler JG, Wascher E, Watzl C. Calibrating a Comprehensive Immune Age Metric to Analyze the Cross Sectional Age-Related Decline in Cardiorespiratory Fitness. Biology (Basel). 2022 Oct 27;11(11):1576. doi: 10.3390/biology11111576.
Reference Type
RESULT
Mundorf A, Getzmann S, Gajewski PD, Larra MF, Wascher E, Ocklenburg S. Stress exposure, hand preference, and hand skill: A deep phenotyping approach. Laterality. 2023 Mar-May;28(2-3):209-237. doi: 10.1080/1357650X.2023.2204551. Epub 2023 Apr 26.
Reference Type
RESULT
Gajewski PD, Rieker JA, Athanassiou G, Brode P, Claus M, Golka K, Hengstler JG, Kleinsorge T, Nitsche MA, Reinders J, Tisch A, Watzl C, Wascher E, Getzmann S. A Systematic Analysis of Biological, Sociodemographic, Psychosocial, and Lifestyle Factors Contributing to Work Ability Across the Working Life Span: Cross-sectional Study. JMIR Form Res. 2023 May 19;7:e40818. doi: 10.2196/40818.
Reference Type
RESULT
Gajewski PD, Brode P, Claus M, Golka K, Hengstler JG, Reinders J, Watzl C, Wascher E, Getzmann S. Changes of cognitive functions and proinflammatory cytokines across the lifespan in latent Toxoplasma gondii infection. Brain Behav Immun Health. 2025 Sep 15;49:101105. doi: 10.1016/j.bbih.2025.101105. eCollection 2025 Nov.
Reference Type
DERIVED
Gajewski PD, Brode P, Claus M, Golka K, Hengstler JG, Watzl C, Wascher E, Getzmann S. The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers. Brain Behav Immun Health. 2024 Nov 23;43:100909. doi: 10.1016/j.bbih.2024.100909. eCollection 2025 Feb.
Reference Type
DERIVED
Related Links
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https://vital-study.ifado.de/home
This is the oficial site of the Dortmund Vital Study
Other Identifiers
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A93-3
Identifier Type: -
Identifier Source: org_study_id